The Greising Lab

Join us for #WebinarWednesday on November 5, Beyond the Bench: Translating Skeletal Muscle Research with Large Animal Models. Explore challenges, best practices, and new tools for bridging small and large animal research. Register now: https://bit.ly/42wEmcO @greisinglab.bsky.social

CORP: In Vivo Muscle Strength- Perspectives on the Design and Interpretation of Preclinical Animal Studies | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | American Physiological Society Accurate and reproducible tools to evaluate skeletal muscle contractility help to advance the field of physiology by defining skeletal muscle function in the context of skeletal muscle development, disease, aging, and injury recovery. The biomechanical assessment of muscle strength can be accomplished by measuring in vivo muscle torque, specifically, the muscle force generated at a moment arm around a joint. This approach to assess skeletal muscle contractility in preclinical animal studies primarily measures muscle torque in anesthetized animals using non-invasive electrophysiological stimulation. This method is advantageous because skeletal muscle contractions are evoked in a controlled, quantifiable manner that is independent of subject motivation allowing for maximal functional data and reproducible research outcomes. The purpose of this Cores of Reproducibility in Physiology (CORP) review is to discuss the underlying physiology of the in vivo method, to highlight common outcomes and their physiological importance, and to provide considerations for technical reproducibility and data interpretation. The hope is this CORP will provide skeletal muscle researchers with the foundational and practical knowledge to better incorporate the in vivo technique in their future studies.

Happy to contribute to this Cores of Reproducibility in Physiology with Drs. Call and Baumann

👋 A big welcome to the newest ORS Section, the Skeletal Muscle Section! Skeletal muscle drives mobility, strength & overall #musculoskeletal health. This Section will advance research in regeneration, aging, trauma, & therapeutics. Learn more & join: ors.org/skeletalmusc...

Join us May 14 at 12 PM CT for #WebinarWednesday as we kick off the session 1 of the Compassionate Leadership Summer Series! Learn to lead with empathy & set healthy boundaries with evidence-based strategies from mental health pros. Free for ORS Members. Learn more and register now: bit.ly/4dLKzFM

“We must expand our #advocacy ... we must defend science itself. Yesterday, 70 attendees of this meeting ... took that message directly to Capitol Hill. This is just the beginning.” —APS CEO Scott Steen #APS2025 #WeArePhysiology #APSHillDay 9/11 🧪

Simon seems to have added a lot of cats to our feed/algorithm?!.... not a bad thing!

#TERMISAM2025

Abstract deadline for 2025 TERMIS-AM Conference is coming up on 4/28! Lots of great musculoskeletal topic areas am2025.termis.org/abstract-ins...

Connective Tissue Research Publishes research on mechanisms and structure-function relationships in the connective tissue extracellular matrix and biological process of tissue repair.

Connective Tissue Research introduced a new early-career researcher award! www.tandfonline.com/journals/ict...

Behind every great woman in science, there’s another great woman in science To mark International Women’s Day on 8 March, six award-winning female scientists highlight women who have inspired them by pushing innovative research and creating opportunities for others.

Six award-winning female scientists highlight women who have inspired them by pushing innovative research and creating opportunities for others

https://go.nature.com/43n0J5R

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular ...

Happy to share this @jphysiol.bsky.social paper from our group as we work to find novel approaches to improve muscle innervation after injury physoc.onlinelibrary.wiley.com/doi/10.1113/...

ORS encourages members to advocate for their research. On March 7, join the nationwide Stand Up for Science rally in Washington, DC, and state capitols. Share with colleagues and learn more at www.standupforscience2025.org. #scienceisforeveryone

Please consider contributing to this special issue of Experimental Physiology (guest edited by yours truly). We are taking submission now!
buff.ly/42YJaIP

Thanks @mayankverma.bsky.social ! Past work that deletes the MRFs has shown disruption of the satellite cell trajectory too, but still a lot to figure out for sure.

Porcine myogenesis in cloned wildtype and MYF5/MYOD/MYF6-null porcine embryo Communications Biology - Triple knockout of myogenic regulatory genes (MYF5/MYOD/MYF6) completely disrupts skeletal muscle formation, causing embryonic lethality in pigs and highlighting the...

Happy to share our recent collaborative @commsbio.bsky.social paper with Mary Garry's lab rdcu.be/d9vko

The ORS Junior Faculty Network meetup will be this Saturday 2/8, 9:30pm at Barrel & Bushel in the Hyatt. See you all there!

As you make final plans for @orssociety.bsky.social annual meeting be sure to add our WLF-sponsored sessions to your agenda!
If you are joining us at the WLF networking reception we have a few of @agilefacultyrpr.bsky.social book's to give away, raffle will be about 6:30 local time

Miguel Pareja-Cajiao, Heather Gransee, Sepideh Jahanian, Gary Sieck and Carlos Mantilla (Anesthesiology & Perioperative Medicine, Mayo Clinic) examine the effects of inhibiting TrkB kinase activity on cervical motor neurons, and how the response differs with age
📜https://buff.ly/3WELSiW

Seeking Faculty and Postdocs? Join us for the Future Faculty Poster Session or the Postdoctoral Fellow Match Poster Session on Sunday, February 9 at #ORS2025 to connect with the future of #musculoskeletal research. 🔗 Request applicant PDFs now: bit.ly/3VpBTxt

Our lab is looking to add a postdoc to our team investigating skeletal muscle function after injury, applicants with expertise in physiology and imaging very welcome! hr.myu.umn.edu/jobs/ext/364...
Reach out with any questions