Matan Geron

Painkillers without the addiction? The new wave of non-opioid pain relief Pharma firms are developing drugs that avoid the brain’s opioid receptors to minimise the risks of dependence and overdoses, but not all experts are convinced

In January, the FDA approved a new non-opioid painkiller. CBP's Grégory Scherrer spoke with @theguardian.com about the new wave of developing non-opioid drugs for pain relief. Read here: www.theguardian.com/science/2025...

www.nature.com/articles/s41...

Nice blurb on our recent paper!

Structure-guided design of a peripherally restricted chemogenetic system Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.

Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice.
www.cell.com/cell/fulltex...

Gene Therapy Breakthrough Targets Peripheral Pain Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm

New from Rothlab!
www.miragenews.com/gene-therapy...

Please add me

Structure-guided design of a peripherally restricted chemogenetic system Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.

I am glad to share our recent work, now published in Cell! A @zenbrainest.bsky.social and Scherrer lab collaboration developing and validating a new peripherally restricted DREADD system! Great team work with Hye Jin Kang, Brian Krumm, @adrtas.bsky.social, and others
www.cell.com/cell/abstrac...

New paper from the lab:
Structure-guided design of a peripherally restricted chemogenetic system
10.1016/j.cell.2024.11.001

Could you please add me? Thank you

I started (at @katesadlerphd.bsky.social's suggestion, thanks Kate for pushing me) a pain neuroscience and pain research starter pack. I am sure I have missed many people so if I missed you, I am sorry, but please just ask me to add you in the thread below and I will do that. go.bsky.app/KboKNhg