Mario Wiesenfeldt

New @chemrxiv.org, a collaboration with @honggen-wang.bsky.social and group alum, now asst prof. Myojeong Kim: the first true catalytic interception of isodiazene-generated primary-amine-derived radicals. The key is an N-F reagent that enables productive chain carrying!

doi.org/10.26434/che...

Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

🚨 PhD Opportunity! 🚨
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...

Thanks Tobi!

I’m proud to share that my group has received a Starting Grant from @erc.europa.eu, which will enable us to explore new organophotomediated reactions, and deeply grateful to my group and the many colleagues who helped with the application.

Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes Divergent synthesis is a powerful strategy that provides simultaneous access to multiple derivatives of a given substrate. However, the emerging developments in skeletal editing have largely delivered...

Our latest is a serendipitously discovered pair of reactions that can pull either the C2 or C3 carbon out of quinolines by choice of an amine scavenger. A deep mechanistic dive took us some surprising places, in @chemiejisoo.bsky.social's latest.

pubs.acs.org/doi/full/10....

Synthesis and Nucleophilic Ring-Opening of 1,1-Dicyanocyclopropanes: Accessing β-Aminocarbonyl Derivatives from Olefins We report an atom-transfer radical addition-ring closure sequence for the preparation of 1,1-dicyanocyclopropane electrophiles and demonstrate their nucleophilic ring-opening with alkyl amines under mild conditions. The resulting aminomalononitrile products were converted to complex β-aminocarbonyl derivatives in one pot under aerobic conditions.

Incredibly proud to finally see @sebastianuitbe.bsky.social first corresponding author paper online! Congrats to Jan (worked on this during MSc thesis) and Mohit for helping to get it done. I must say, I really enjoyed working on this paper!

pubs.acs.org/doi/10.1021/...

Lewis-Base-Catalyzed Asymmetric Allylation of Isatins with Allyltrichlorosilane Herein we report the enantioselective synthesis of 3-allyl-3-hydroxyoxindoles, a core scaffold in a wide range of bioactive molecules, using a Lewis-base catalyst and readily abundant and inexpensive ...

Yase's work on the Lewis-base-catalysed asymmetric allylation of isatins is now online, congrats!
pubs.acs.org/doi/10.1021/...

🚀 Join Us!
We have an exciting opportunity to join our research group!

This fully funded PhD position is part of the IPCat training programme.

Feel free to reach out if you have any questions or need more information.

👉 Apply now: www.findaphd.com/phds/project...

#PhD #compchem

Multiprobe Photoproximity Labeling of the EGFR Interactome in Glioblastoma Using Red-Light Photocatalytic proximity labeling has emerged as a valuable technique for studying interactions between biomolecules in a cellular context, providing precise spatiotemporal control over protein labeling. One significant advantage of these methods is their modularity, allowing the use of a single photocatalyst with different reactive probes to expand interactome coverage and capture diverse protein interactions. Despite these advances, fewer methods have been developed using red-light excitation, limiting the use of photoproximity labeling in more complex media such as tissues and animal models. Herein, we develop a platform for proximity labeling under red-light excitation, utilizing a single catalyst and two distinct probe types. We first design a carbene based labeling system that utilizes sulfonium diazo probes. This system is successfully applied on A549 cells to capture the interactome of epidermal growth factor receptor (EGFR) using a Cetuximab-Chlorin e6 conjugate. Benchmarking against established techniques indicates that this approach performs comparably to leading carbene-based proximity labeling methods. Next, we leverage the strong singlet oxygen generation (SOG) ability of Chlorin e6 to establish an alternative labeling system using aniline and hydrazide probes. EGFR directed chemoproteomics experiments reveal significant overlap with the carbene system, with the carbene approach capturing a subset of interactions identified by the SOG system. Finally, we deploy our approach for the characterization of EGFR in resected human glioblastoma (GBM) tissue samples removed from distinct locations in the same tumor, representing the tumor’s infiltrating edge and its viable center, identifying several GBM specific interacting proteins that may serve as a launch point for future therapeutic campaigns.

Our first paper is out today in @jamchemsoc.bsky.social!
This is the beginning of a long journey for us, to study heterogeneity in GBM patient samples.
First step was to figure out some chemistry to enable us to look at this challenging problem.

pubs.acs.org/doi/10.1021/...

Asymmetric Counteranion-Directed Halogen Bonding Catalysis Halogen bonding has been established as a promising tool in organocatalysis. Asymmetric processes are nevertheless scarce, and their applications are limited to a few studies applying chiral halogen b...

The combined power of halogen bonding and asymmetric counteranion-directed catalysis = XB-ACDC: pubs.acs.org/doi/10.1021/.... Thanks to @mertenlab.bsky.social for structure elucidation and to the List group for this beautiful cooperation! A perfect #RESOLV project! @solvationsci.bsky.social

We start our first post on Bluesky with a firework! Very proud of a brilliant team to publish our work on C(sp3)-atom transfer @science.org. www.science.org/doi/10.1126/... It has been a very exciting journey. Thanks @erc.europa.eu

A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are di...

Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨

pubs.acs.org/doi/10.1021/...

Thanks Nick!

Our study on the partial reduction of arenes to cyclohexenes is now online in J. Am. Chem. Soc. Congrats to Kirti and Asad! pubs.acs.org/doi/full/10....

We are hiring (resharing appreciated)!

Given recent successful grant applications (I got my SNSF Starting Grant 🚀), we are extending the LIAC team with multiple openings (PhD/postdoc) for 2025.

Apply now (deadline: December 20th) by filling in this form: forms.fillout.com/t/eq5ADAw3kkus.
#ChemSky

I am beyond excited to announce that I will be joining the Department of Pharmaceutical Sciences at the University Vienna (@univie.ac.at) as a Tenure Track Professor in March 2025! Thanks to the support of the LMU, I will also continue to work as a group leader in Munich for the foreseeable future!