ATBiju Group

HFIP-Mediated Ring Opening of Bicyclo[1.1.0]butanes with Hydroperoxides for Diastereoselective Access to Peroxycyclobutanes A transition-metal-free ring opening of bicyclo[1.1.0]butanes (BCBs) using hydroperoxides as nucleophiles in hexafluoroisopropanol (HFIP) resulting in the diastereoselective synthesis of peroxycyclobutanes under mild conditions with a broad scope is demonstrated. Preliminary mechanistic experiments, including density functional theory studies, provide insight into the mechanism and stereochemical outcome of the reaction, thus underscoring the unique role of HFIP in activating BCB for facile nucleophilic addition.

We can now use hydroperoxides as nucleophiles for the mild & diastereoselective ring-opening of BCBs in HFIP, just out in Org.Lett.!

Thank you SERB/ANRF for funding this work🙏, done by our UG student Priyanshu supported by Palash😃!

Organic Letters pubs.acs.org/doi/10.1021/...

13.09.2025 06:14 — 👍 2    🔁 0    💬 0    📌 0

Our Int. PhD. member Soumen Barik has presented his work on NHC-Catalyzed Routes to C-N Atropisomers and Heteroatom Chiral Molecules in the Thesis Colloquium😊.

Wonderful work and nice presentation, Soumen👏!

All our best wishes for your Thesis submission👍!

30.08.2025 08:35 — 👍 2    🔁 0    💬 0    📌 0

A promotional image with RSC iconography of Professor Ning Jiao

We are delighted to share Professor Ning Jiao's Editor's Choice collection in synthetic, organic and catalytic chemistry with you!

See which papers are included in this collection here:
blogs.rsc.org/sc/202...

All papers published in Chemical Science are free to read!

01.08.2025 15:19 — 👍 4    🔁 1    💬 1    📌 0