Tau phosphorylation also relieves inhibition of lysosome transport by tau in neurons and alters the distribution of lysosomes in axons.
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Cooperatively-bound tau inhibits kinesin-1 (KIF5B) motility, and inhibition is relieved by phosphorylation. In contrast, kinesin-3 (KIF1A) is strongly inhibited by both phosphoresistive and phosphomimetic tau.
04.08.2025 17:50 β π 0 π 0 π¬ 0 π 0
Similarly, phosphorylation blocks the ability of tau to bind cooperatively in neurons
04.08.2025 17:47 β π 0 π 0 π¬ 0 π 0
A few highlights from our new preprint:
On taxol-stabilized microtubules In vitro, wild-type (WT) and phosphor-resistive (AP) tau form well-defined envelopes, while phosphomimetic (E14) tau does not bind cooperatively.
04.08.2025 17:43 β π 10 π 2 π¬ 3 π 0
Steven M. Block
Steven M. Block | 2025 Benjamin Franklin Medal in Life Science
fi.edu/en/awards/la...
youtu.be/yeZJXeQo3JQ?... via @YouTube
07.05.2025 09:10 β π 10 π 3 π¬ 1 π 0
Great chance for Canadian researchers to attend a great scientific meeting in Canada!
01.04.2025 15:48 β π 3 π 4 π¬ 0 π 0
Competition for microtubule lattice spacing between a microtubule expander and compactor. https://www.biorxiv.org/content/10.1101/2025.02.28.640185v1
03.03.2025 23:30 β π 2 π 1 π¬ 0 π 0
Research Scholar, IIT Bombay
Interests: biophysics, cell biology, nature, sports.
Assistant Professor at UC Berkeley. Cytoskeleton and transport in glia. Prev: NIH, Stanford, UPenn, Caltech.
PhD student at Karolinska Institutet and Scilifelab | Cell physics
https://www.csi-nano.org/
Research Associate at Colorado State University | axonal trafficking β’ microtubules β’ motors β’ synaptogenesis β’ iPSCs
Aiken Lab! π§
Former RA @ucsantabarbara @stanford
DPhil student @intelligentearth.bsky.social & Oxford biology graduate.
Machine learning, biodiversity, sensory ecology, biologgers, birds
Next-generation RNA splicing modulation platform dedicated to transforming patient outcomes in severe genetic diseases #RNAtherapeutics #RNAsplicingmodulation #Pseudoexon #Parkinsons #Huntingtons
PostDoc, antisense oligomers, computational (micro)biology, antibiotics, π¦ bacteriaπ¦ , microbiome, immunology, AMR, global health, statistics.
he/him
https://linkedin.com/in/jakob-jung/
https://github.com/jakobjung
https://mstdn.science/@jakobjung
The premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research. Editor-in-Chief: Vasanthi Jayaraman.
Official account for the Biophysical Society, founded in 1958 to lead the development and dissemination of knowledge in biophysics.
Part scientist, part fun-lover, part storyteller and endlessly curious about how tiny cellular dramas shape the bigger picture!
MS Biology, MPH, MS Cybersecurity |
Evolutionary Biologist πͺΌ| SciComm βπ»|
Bioinformatician π₯οΈπ§¬| Public Health π|
Notorious Bot Hunter π| PNW π²|
Git π₯οΈ: https://github.com/bpwhite
Art π¨: https://crvscience.com
Coffee β: https://buymeacoffee.com/crvscience
Postdoc in the Fritz-Laylin lab, fascinated by obscure protists. Evolutionary Cell Bio research on amoebae & cytoskeleton. Sometimes art. she/her.
Bioscientist. Associate Professor at Rice University. Neural crest, zebrafish, enteric nervous system, gut-brain axis, neurodevelopment. Editor-in-Chief, Differentiation.
Scientist studying molecular motors, highways, and cargoes.
PhD student in biophysics/biochemistry working on the interaction between the phosphorylated Tau protein and microtubules. Molecular dynamist. Tamer of IDRs and IDPs since 2022
(They/Them)
https://scholar.google.com/citations?user=4S1QUPgAAAAJ&hl=fr
Cellular Nanoscience Lab at University of TΓΌbingen
Managed by lab members
https://tinyurl.com/CellNano
Studying why and how behavior evolves, from mosquitoes to mole-rats | Postdoc/Leon Levy Scholar @Columbia working with Ishmail Abdus-Saboor | PhD @Princeton with Lindy McBride | ιΊ»εΈ/ζ±ε€§ alum π―π΅ | yukihaba.github.io
Danish biotech start-up builder living in Paris | RNA Tx & immunotherapy aficionado | Family barista | KongeblΓ₯ & Gooner
D2R | DNA to RNA is a research initiative at McGill University taking an inclusive Canadian approach to developing genomic-based #RNA therapies for rare diseases, infectious diseases and cancer.
www.mcgill.ca/dna-to-rna/
