Akul Mehta

Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23...
#glycotime #glycosylation #science #artificialsweeteners

Gut mucin fucosylation dictates the entry of botulinum toxin complexes - Nature Communications Botulinum toxins vary in oral toxicity, but the reasons are unclear. Here, the authors show that the differences can be due to variations in one of the toxin’s components, the hemagglutinin complex, w...

Gut mucin fucosylation dictates the entry of botulinum toxin complexes www.nature.com/articles/s41...

For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]

Update and new implementation of the MIRAGE reporting guidelines for mass spectrometry experiments in glycoscience The MIRAGE (Minimum Information Required for A Glycomics Experiment) guidelines for mass spectrometry (MS) data were initially developed to standardize the reporting of instrumentation, data acquisiti...

Cannot hide my joy, relief, excitement being able to share the outcome of persevering (to say the least) collaborative work. So... the MS glyco(proteomics) guidelines are published!! www.mcponline.org/article/S153...
Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss

Meeting Report on the 1st GlyCosmos Symposium & Jamboree —Community-Driven Expansion of Glycan-Binding Molecules Resources Chiaki Nagai-Okatani, Masae Hosoda, Winnie Hsiung, Takashi Sato, Hiroaki Sakaue, Sayaka Fuseya, Eriko Fukuda, Issaku Yamada, Kiyoko F Aoki-Kinoshita, Atsus

We are excited to share our #glycotime meeting report on the 1st GlyCosmos Symposium & Jamboree in *Glycobiology*!
DOI: doi.org/10.1093/glyc...

Participants advanced glycan-binding molecule resources through hands-on work on lectin curation and FAIR glycoinformatics within #GlyCosmos.

It's finally here! serversideup/php v4 is now stable 🎉

😅 Over a year of work
🐘 FrankenPHP & Laravel Octane support
🤖 LLM integration on our docs
🤝 13 new contributors
❤️ All open source

Run PHP and Laravel anywhere you want.

Now go build awesome stuff, Internet. 🚀

Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.

1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis

2. Proteins are a source of glycans found in preparations of glycoRNA

Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!

The @nuxt.com team is highly underrated 💯

I'm working with Nuxt Content, and this product blows my mind 🤯

It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too.

You know you're crushing it when a SERVER GUY compliments JavaScript 🤓

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cance...

Sharing our recent pre-print where we drill down further into the transcriptional regulation of Siglec ligands. Here we show that tissue specific regulatory networks dictate changes in sialoglycan patterns. Work led by Rebecca Garnham and postdoc Adam Duxfield.

www.biorxiv.org/content/10.1...

Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide - Nature Communications Authors identify and characterize 16 endo−1,3-fucanases within the GH168 family sequence space, unveiling a recognition mechanism for sulfate polysaccharides. These findings can promote the applicatio...

Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺

"Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍

www.nature.com/articles/s41...

You're kidding me!? 👀

TIL about "post_start" in Docker Compose 🐳

You can run commands as a privileged user on startup, but still run your services as an unprivileged user.

This dramatically simplifies bootstrapping an app! 🤩

serversideup/php v4.0-beta1 is now available!!!

It's a next level Docker image:

🐘 FrankenPHP now available
❤️ Improved native health checks
🤖 Advanced Laravel automations
🤩 12 new contributors

Our biggest open source release yet. LET'S GO PHP!! 🚀

💯

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To be honest all places are quite awful right now, for different reasons.

If there was a certain vendor developing a brand new ion mobility instrument and is in the process of choosing a file format, this is timed incredibly well for them to catch the wave.

We're hiring! 🚀

**PhD positions:**
Computational focus:
web103.reachmee.com/ext/I005/103...
Experimental focus:
web103.reachmee.com/ext/I005/103...

**Postdoc positions:**
Computational focus:
web103.reachmee.com/ext/I005/103...
Experimental focus:
web103.reachmee.com/ext/I005/103...

Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine

employment.ku.dk/faculty/?sho...

Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!

This is remarkable and obviously fantastic science. I have always wondered though, wouldn't the transplanted organ just start expressing the blood group antigens eventually in the recipient? And therefore making this a temporary solution rather than a permanent one.

Most people think that #glycosylation is only extracellular. But there is increasing evidence for the existence of intracellular proteins also being glycosylated. Check out this blog post to learn more about this topic!

Arcaneering: Beyond Automation on Steam Automate the arcane! Build spell-powered factories, reclaim ancient territories filled with magical secrets, and discover game-changing technology hidden across procedurally generated worlds. Master b...

Here's something non-science-y for a change:
Check out the free demo of my upcoming game on Steam! 🥳
store.steampowered.com/app/3858960/...
(Arcaneering is a cozy factory automation game, with a bit of RPG elements, made in Godot)
#gamedev #indie #pcgaming #automation #basebuilding

Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase - Glycopedia Oligosaccharyltransferase (OST) catalyses the key step of N-glycosylation, transferring immature N-glycans to select Asn residues in nascent proteins in the endoplasmic reticulum (ER). Asn are more li...

Our work @benschulz.bsky.social on the specificity and the mechanism of activation of the eukaryotic oligosaccharyltransferase is now on Glycopedia ⬇️🎉🥳, the largest repository of #glycotime news and educational material online!

Thank you Serge Perez 🤓❤️

glycopedia.eu/2025/09/09/r...

5. Abrupt end of the review as the AI probably ran out of tokens.

4. Slowly over the course of the review, AI starts to want to rewrite your entire manuscript for you "I moved the statistical significance sentence up because it is a natural follow-up of the sentence …" The current state of AI, it likes to generate text not to be critical of it.

Example:
"-line XX: … Whats does it mean to study well? Properly? Using right methods? Comprehensively, covering a wide range of possible candidates?"

For context, several of the authors on that paper were native English speakers and all of them had proof-read the paper. But AI used this as an excuse to improve the language, even where it wasn't needed. 40% of the review was just this.

3. AI assumes you are a non-native English speaker even if you are. It will try to rephrase everything you say just to make it sound better. In my colleagues review it stated "…. (obviously not proof-read by a native speaker) …"

Another example it cites Wikipedia "Elution - Wikipedia Please be aware of the difference between an eluate and an eluent" or other web-based resources often instead of actual journal articles. This is because LLMs have access to web-based resources for training but not as much pay-walled articles.

2. AI cites very strange evidences for their statements. In my colleagues review they stated the following "As I checked in Scopus, the authors have an expertise on the biology and biochemistry of … , so I expected to read a sound work."