Siavash Moghadami

Cell's sugar coating mapped at below-nanometre resolution Nature - Super-resolution technique works with off-the-shelf optical microscopes.

Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes

go.nature.com/40I9Ewv

Jennifer Doudna is named 2026 Priestley Medalist The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership

@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪

Shoot me a message if you want to meet!

I’ll be in Irvine, CA, from August 18–20, 2025, attending the 2025 Conference “The Changing Brain.” Excited to connect with fellow professionals passionate about neuroscience! If you’re attending or in the area, let’s meet up to discuss the latest advancements in brain science.

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

What an amazing time to be a biomedical scientist.

www.nejm.org/doi/abs/10.1...

Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...

More insights into #glycoRNA, this time found within exosomes!

www.nature.com/articles/s41...

Great to see #proudofalumni @nmriley.bsky.social on the @cenmag.bsky.social Talented 12 list! 🎉 🏆 Check out his #glycotime research program:

www.riley-research.com

Great piece on @stanford-chemh.bsky.social Institute Scholar @stanleyqilab.bsky.social’s work toward curing diseases with genome editing innovations #ResearchMatters

PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry Intrathecally dosed antisense oligonucleotide distribution can be imaged in rat and nonhuman primate brains using a PET tracer and click chemistry.

Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯

www.science.org/doi/10.1126/...

Cell surface RNA biology: new roles for RNA binding proteins Much of our understanding of RNA–protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking…

“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...

Scientists recreate brain circuit in lab for first time Research breakthrough promises new treatments for severe pain

Brief overview in @data.ft.com of recent work to build four-part assembloids as a model of the human somatosensory neural pathway

www.ft.com/content/f8d5...

Advancing #glycoRNA imaging with FRET-based detection and expanding the scope of their presentation to extracellular vesicles - interestingly high levels of sialoglycoRNAs on blood EVs can be predictive of having cancer @naturecomms.bsky.social

www.nature.com/articles/s41...

Congratulations @pollyfordyce.bsky.social🎉 Very well-deserved!

Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025 Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025

Huge gain for @nygenome.org and @columbiauniversity.bsky.social! I enjoyed learning from such a fantastic scientist during my undergraduate time!

www.nygenome.org/news-events/...

Induced proximity at the cell surface - Nature Biotechnology Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan

www.nature.com/articles/s41...

Lab Administration Research Technician- Bertozzi Lab Primary Work Address: Beckman Center, Stanford, CA, 94305-5323 Current HHMI Employees, click here to apply via your Workday account. We are currently looking for a highly motivated Lab Administration ...

We are seeking to hire a lab tech, this is an HHMI funded position, please share the job posting:

hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Spatial and molecular insights into microglial roles in cerebellar aging https://www.biorxiv.org/content/10.1101/2025.03.01.640978v1

Thank you @cenmag.bsky.social for this nice piece on @sophiamshi.bsky.social’s PhD work revealing a mucinome defect in the aging BBB, reversible with gene therapy to restore brain endothelial mucin glycosylation

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏

www.cell.com/cell/abstrac...

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...

Check out our web tool for searching for interactors of your favorite cell surface protein, developed by undergrad Pinyu Liao and postdoc postdoc Brendan Floyd @stanford-chemh.bsky.social

cellsurfacemap.org

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...

NIH cuts billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.

www.washingtonpost.com/health/2025/...

Predictions for AI in 2025: Collaborative Agents, AI Skepticism, and New Risks Leading Stanford faculty offer their expectations for artificial intelligence in the new year.

hai.stanford.edu/news/predict...

Happy to share this #glycotime collaborative work with Jim Brooks lab @stanfordmedicine.bsky.social just out @jclinical-invest.bsky.social. Siglec/sialoglycan axis mediates immune suppression in prostate cancer.

www.jci.org/articles/vie...

Maybe a good time to plug this awesome book edited by former PhD students Howard Hang (Scripps), Matt Pratt (USC), Jenn Prescher (UC Irvine), featuring chapters by leaders in the field including @jeremybaskin.bsky.social and a forward by yours truly.

Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...

Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses

www.nature.com/articles/s41...

Ångström-resolution fluorescence microscopy - Nature The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off...

Very nice paper!
www.nature.com/articles/s41...

Yay!! @amerchemsociety.bsky.social is in the house clap👏

Carolyn Bertozzi’s latest biotech debuts with $30M seed round and a sugary spin on immunotherapy Valora Therapeutics has $30 million to jumpstart research on immunotherapies based on sugars — the kind that dots cell surfaces and help devastating cancers evade immune system attack.

Congratulations to the Valora Therapeutics team on an exciting launch; it is a privilege to work with cofounders @jcstark.bsky.social at MIT/Koch Inst and biotech veteran/CEO Miguel Garcia-Guzman, bringing the #AbLec technology to patients. #glycotime

endpts.com/carolyn-bert...