Ferdinando Pucci

Profiling antigen-binding affinity of B cell repertoires in tumors by deep learning predicts immune-checkpoint inhibitor treatment outcomes - Nature Cancer Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-ch...

📢Another Article ONLINE at Nature Cancer!
'Profiling antigen-binding affinity of B cell repertoires in tumors by deep learning predicts immune-checkpoint inhibitor treatment outcomes'

✒️By Junzhou Huang, David Gerber, Tao Wang and colleagues

🔗 www.nature.com/articles/s43...

Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses Humans cannot perceive infrared light due to the physical thermodynamic properties of photon-detecting opsins. However, the capability to detect invis…

Now this is cool:
www.sciencedirect.com/science/arti...

#cancer #spatialbiology #immunohistochemistry #patientsurvival #immunology | ariadne.ai ag Join us for an exciting webinar! 🔬 We’re thrilled to host Ferdinando Pucci, Assistant Professor of Otolaryngology, Cell, Developmental, and Cancer Biology at…

Looking forward to a very interactive session! #spatial #biology #IHC #EVs #extracellularvesicles #Bcells #headneck #cancer
www.linkedin.com/posts/ariadn...

First #faculty #interview is over, albeit with a nay. Great pleasure to discuss my science and meet the smart investigators at the Immunology Center of GA! Drs. Ley and Hedrick are building a fantastic team. Looking forward to find a new home for my ACS grant (~$1M, 4y, 10% #indirects). Stay tuned!

Modular and Nondisturbing Chimeric Adaptor Protein for Surface Chemistry of Small Extracellular Vesicles Current chemical strategies for modifying the surface of extracellular vesicles (sEVs) often struggle to balance efficient functionalization with preserving structural integrity. Here, we present a mo...

Exciting to see more engineering of #EVs toward therapeutic solutions.

Cool germinal center acrobatics from Juhee Pae et al, check it out!

www.nature.com/articles/s41...

Our recent work on #extracellularvesicles in #aging and #cancer #recurrence received a nice commentary from Dr. Sonia Melo! Thank you

aacrjournals.org/cancerres/ar...

Many kudos to the rest of the team as well, including Laura Heiser team (OHSU), Pacific Northwest National Laboratory scientists, Matthew Hoare (Cambridge University) and former lab members.

Huge thanks to Cancer Research UK (CRUK) for jumpstarting this project back in 2020, and to OHSU CDCB T32 support to Tahereh Ziglari, the lead scientist of this study. This work would have not been possible without her dedication and hard work.

These findings support the use of senescent cell EVs as a novel immunotherapy to prevent or treat cancer #relapse.

#aging #SCC #headandneck #exosomes

We found that senescent cells release lots of EVs, which recruit immune cell types involved in antigen presentation. Senescent cell EVs seem to support immune synapse formation with CD4 #Tcells, and both were required to ultimately remove senescent cells and avoid tumor recurrence.

Graphical abstract

Thrilled to see our most recent work online at Cancer Research.

aacrjournals.org/cancerres/ar...

In this paper, we elucidate the roles of #extracellularvesicles (#EVs) in #cell #senescence, which is important in the context of tumor #recurrence after #chemotherapy.

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Sustained lymphocyte migration from blood into lymph nodes (LNs) is important for immune responses. The CC-chemokine receptor-7 (CCR7) ligand CCL21 is…

www.sciencedirect.com/science/arti... Another piece of the puzzle: oxysterols recruit B cells into tumors. More data more Q: are these recruited naive B cells the ones that suppress tumors or do B cells need to visit the lymph nodes first? #Bcells #cancer #inflammation

Postdoctoral Fellow - Moltke Lab Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

We're hiring! Funded postdoctoral position available in the Moltke Lab. 79k starting salary and access to a fellowship program in the Institute for Translational Immunology that offers both academic and industry training tracks. Details here: jobrxiv.org/job/universi...

I do, but it looks like I may not be eligible based on time from PhD? Please keep me posted if other opportunities arise!

How about cancer immunology? I may be interested!

3. What about the subcapsular sinus? What differences do you observe there between NN and NP?

2. I understand segmentation may have been limiting, with only 35k cells per section? 2.5M over 70 samples? Unfortunately that is a common limitation of current analysis pipelines, it is unclear how this may impact the results. Thoughts?

Check out this amazing manuscript from Dr. Keren. I fully empathize with the amount of work that goes into this kind of studies! A few thoughts after skimming it: I'd love to know if the organization of GCs into DZ and LZ differs between NN and NP, as we saw in our preprint;

Super grateful to American #Cancer Society for a research scholar grant to keep up our work on #bcells anti-tumor activity 🙏🏼

Senescent cell-derived extracellular vesicles inhibit cancer recurrence by coordinating immune surveillance Extracellular vesicles (EVs) are key signaling mediators. To explore the role of senescent cell-derived extracellular vesicles (senEVs) in inflammatory responses to senescence, we developed an engraft...

Waiting for the final ok from the reviewers after the second review in #cancer #research @theaacr.bsky.social #senescence #extracellularvescicles www.biorxiv.org/content/10.1...

Just got reviewers feedback on this. We're going to make it even better! #cancer #research #bcell #extracellularvescicles papers.ssrn.com/sol3/papers....

Hey folks!

The National Postdoc Association announced that they will be giving free memberships to undergrads, graduate students, & postdocs that attend or work for Historically Black Colleges & Universities (HBCU).

They have lots of great resources so please take them up on their offer!