@mitenjain.bsky.social
As mentioned above this is still very early R&D work, not ready for release yet.
We are generating more data and @stoibs11.bsky.social's team has got plenty of ML magic tricks to significantly improve the performance of the models.
Selected areas of Human rRNAs showing modification calls in IGV. Samples sequenced by ONT direct RNA sequencing with experimental Remora models calling m6A, m5C, PseudoU, and all 4 2'Ome modifications.
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing.
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
This is worth looking at. Trying some genomes we have assembled with earlier versions of hifiasm, hifiasm plus herro and then this new version of hifiasm. The early assembly results suggest that now hifiasm alone is equivalent to what we got with herro but with less compute!
28.11.2024 12:58 — 👍 21 🔁 5 💬 0 📌 0Thank you @theoreticalfun.bsky.social and @danrdanny.bsky.social!
14.09.2023 13:29 — 👍 3 🔁 0 💬 0 📌 0
