Kristiina Kanerva

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...

10.11.2025 10:41 — 👍 1    🔁 1    💬 0    📌 0

Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.

Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.

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06.11.2025 19:05 — 👍 76    🔁 23    💬 1    📌 3