Henne lab

Thanks Ilya! Great meeting and great folks.

Another great EMBO #LipidDroplets workshop in Sant Feliu de Guixols! Many thanks to Maria Bohnert, Robin Klemm, and Bianca Schrul for the wonderful organization!

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Congrats Sarah!

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!

We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.

doi.org/10.1083/jcb....

Great department! Most departments at UT Southwestern are actively or will soon be actively recruiting new PIs. Please consider joining us!

Quantitative imaging of lipid transport in mammalian cells - Nature Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...

We’ve used these dyes and they’re great! #lipidtime

Thanks Jan!

Thank you indeed-great read and excellent discussion on our recent papers identifying molecular mechanisms that (I) connect cellular forces to organelles and (II) enable elaborate membrane systems to respond to mechanical challenge

Join us on Sept 18th as we welcome Dr. @sesmalab.bsky.social to our PROVIDES Seminar Series. Dr. Fernández-Sesma will lead a research seminar on Immune responses to dengue virus infection and vaccination. Don’t miss the opportunity to learn about her research efforts.

Thankful to @jcb.org and @lammerdinglab.bsky.social for highlighting our work together with work from @schliekerlab.bsky.social on the endoplasmic reticulum and proteins that influence ER shape and mechanical properties.

Assistant Professor - Cell Biology Discover Assistant Professor - Cell Biology and other Faculty and Physicians jobs in Dallas, TX and apply online today!

Love cell biology? Come be our neighbor!

The Dept of Cell Biology at UT Southwestern is advertising two tenure-track Assistant Professor positions. Generous startup & a great academic community. See ads below:

jobs.utsouthwestern.edu/job/22292356...

jobs.utsouthwestern.edu/job/22292357...

...and still no lipid droplets...we've failed the internet. : (

Congrats James!

Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...

@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social

Hi Claudia! Probably the best tools for this are the DGAT inhibitors. There are specific inhibitors for DGAT1 and DGAT2. Adding both to cell at the same time is an effective way to inhibit TAG biosynthesis and thus LD biogenesis.

Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
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Congrats beautiful work!

Congratulations!

We had a great kick-off of our Lipid Metabolism & Neurodegenerative Disease Mini-symposium! Many thanks to all speakers and attendees! #UTSW_science

Beautiful science and scenery at the #CSMetabolites2025 meeting in Sitges, Spain.

Thanks Ilya!

Paraoxonase-like APMAP maintains endoplasmic-reticulum-associated lipid and lipoprotein homeostasis Here, Paul et al. show that APMAP is an ER-localized paraoxonase-like enzyme that suppresses lipid oxidation and redox stress at the ER network. APMAP loss leads to ER stress, redox disruption, phosph...

Proud present our latest work led by Blessy Paul, now in Developmental Cell @cellpress.bsky.social.

Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation.

www.cell.com/developmenta...

Congratulations!

🚨 Abstract deadline 🚨 48th European Lipoprotein Club: eas-elc.org 👉 April 24th. If you love metabolism and related disorders this meeting is for you. Speakers: Ana Paula Arruda, Oliver Bruns, Antje Körner, Claudia Monaco, and Keynote Phil Scherer plus 35 talks selected from abstracts!
Please repost

Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan - Nature Metabolism The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.

Really interesting work identifying Drosophila gut hormone tachykinin, which influences appetite, sleep, and lifespan.

www.nature.com/articles/s42...

Wonderful post-doctoral opportunity in the Bonifacino lab!