Tim Craig

In other words no chance. Hmm what could we do to help prevent the worst possible outcomes?

Who is our favorite mRNA cyclic peptide display vendor? Fuji? Wuxi?

Got another 16 nM miniprotein binders from Bindcraft. Pretty cool

archive All of our seminars are recorded, and once we receive permission from the speaker, we release the video on our youtube channel

I have found the videos here very useful: www.bpdmc.org/archive

Is it possible to run this on a 40gb gpu?

Awesome- any structure based insights on how to make this process more efficient/faster to improve recombinant membrane protein expression?

Name 3

This is not really true

Nice article. I guess one thing that I would add is that this desire is not new, and nearly everyone has been enhanced through vaccines

The original human enhancement- getting vaccinated

The attached paper seems like it has to do with chip design. Wrong link perhaps? Interested in the protein interaction system…

Why does it have to be anything besides that?

I think it’s here now. It’s pretty hard to get access to sufficient compute resources for things like bindcraft, at least for me. Takes weeks of running and 9 business days to order the genes ($89 each) and finish the expression +binding confirmation.

Scalable protein design using optimization in a relaxed sequence space Machine learning (ML)–based design approaches have advanced the field of de novo protein design, with diffusion-based generative methods increasingly dominating protein design pipelines. Here, we repo...

www.science.org/doi/10.1126/... Found this post while I was searching for comments regarding RSO performance, enjoy the paper!

BindCraft: one-shot design of functional protein binders https://www.biorxiv.org/content/10.1101/2024.09.30.615802v1 Protein-protein interactions (PPIs) are at the core of all key biological processes. However, the co

BindCraft: one-shot design of functional protein binders https://www.biorxiv.org/content/10.1101/2024.09.30.615802v1

Thanks for this!