Super exciting study linking diet to Colibactin producing bacteria and its impact on CRC. Check out our MOTM highlight on this at cmmc.gnps2.org or bsky.app/profile/microbialcmmc.bsky.social/post/3lnnjphdu3c2o

Thanks to all our lovely collaborators for this accomplishment!

We are back again with the April Molecule of the month featuring Colibactin! Check out more at cmmc.gnps2.org

Great introduction to the PODP with a highlight on making data public and usable 😊

Glad you like it 😄

Happy March! While there’s so much to say about our friendly neighborhood Riboflavin, here we show some highlights. It’s amazing how we can engineer bacteria for commercial production!

Check out more at cmmc.gnps2.org

got microbial metabolites? Add to the public knowledgebase available through GNPS2!

cmmc.gnps2.org

Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice Bile acids (BAs) are steroid detergents in bile that contribute to fat absorption, cell signaling, and microbiome interactions. The final step in thei…

sciencedirect.com/science/article/pii/S0022227522001304?via%3Dihub

nature.com/articles/s41575-024-00914-3

science.org/doi/10.1126/science.adl4100

nature.com/articles/s41586-020-2047-9

Was great to see this AMAZING talk by Robert Quinn of @quinn-labs.bsky.social here at UCSD. This talk included a history of the discovery of amine conjugated bile acids, the enzymology behind them, and their impact on health and disease.
Some featured papers in his talk shared below:

How does metabolomics help agriculture? Human health? A brief overview of this fungal metabolite-Fumonisin B2- shows the importance of this overlap. Check out more at cmmc.gnps2.org

Another impactful study of this metabolite: pubs.acs.org/doi/full/10.1021/jf0718906

Modulating the human gut microbiome and health markers through kombucha consumption: a controlled clinical study - Scientific Reports Scientific Reports - Modulating the human gut microbiome and health markers through kombucha consumption: a controlled clinical study

"How does kombucha impact the gut microbiome and health? 🧬🍵 Our new study explores this popular fermented tea's subtle effects on gut bacteria and biochemical markers in a Western diet context. Dive into the findings:

www.nature.com/articles/s41...

Wow—a probiotic Ozempic pathway?

Free fatty acid receptor Ffar4 low in diabetic patients and mouse models, boosts sugar intake

Ffar4 KO, microbiome, and metabolite study pinpoint how Bacteroides vulgatus and its metabolite pantothenate promote GLP-1 secretion

Paper: www.nature.com/articles/s41...

This is figure 1, which shows the gut microbiota–brain axis.

A Review in Nature Reviews Microbiology explores the pathways linking the gut and the brain and examines the microbial, endocrine and neural mechanisms involved in the gut microbiota-brain axis and their impact on gastrointestinal and neuropsychiatric health.
https://go.nature.com/3DSeS0d 🔒

Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition - Nature Communications Here, using a multisystem approach, the authors characterize the impact of Moderate Acute Malnutrition (MAM) on the gut-brain axis and its effects on cognitive and microbiome development in one-year-o...

Our latest publication suggests that there is a link between infant malnutrition, the microbiome, the plasma lipidome and cognitive function. Out now in
@naturecomms.bsky.social #Lipidomics #TeamMassSpec
www.nature.com/articles/s41...

An oldie but a goodie 😊

Interested in using the CMMC knowledgebase or contributing your data? Check out this workshop to learn how or see us at cmmc.gnps2.org

Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.

OUT NOW - Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection

www.nature.com/articles/s41...

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...

Really cool paper that expands our knowledge of combinatorial antibiotic interactions. Bacteria can become resistant to multiple antibiotics at the same time, but they ALSO can become sensitive to other antibiotics (trade-offs). #Microsky #vetmed #betterdatasavespets www.nature.com/articles/s41...

Happy new year to all! We are back again with TWO featured metabolites. Check it out at cmmc.gnps2.org/molecule_month/

Big thanks to @microbialcmmc.bsky.social for the 1st hands-on webinar on reverse #metabolomics on 11 Dec 2024.
@vincentlamoureux.bsky.social , Victoria Deleray, Helena Mannochio Russo, @shipei-xing.bsky.social , @pieterdorrestein.bsky.social

Sign up - CMMC Workshop - Introduction to Reverse Metabolomics- Dec. 10 9am PST The CMMC invites PAR-21-253 Grantees, Collaborators, POs, and Lab Members to the beginner friendly, hands-on workshop to look for microbial metabolites in the public domain.

Signup:
docs.google.com/forms/d/1PsB...

Welcome to CMMC!

We are excited to announce our upcoming workshop designed to be interactive and beginner friendly. We will introduce Reverse Metabolomics, a novel approach to identifying microbial metabolites using mass spec. We will show YOU how to identify and categorize microbial metabolites!