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Derek Lowe

@dereklowe.bsky.social

Medicinal chemist / chemical biologist, author of “In the Pipeline” at http://science.org/blogs/pipeline. derekb.lowe@gmail.com and on Signal at Dblowe.18 All opinions are mine; I don’t speak for my employer in any way.

16,125 Followers  |  736 Following  |  2,214 Posts  |  Joined: 08.10.2023  |  2.0085

Latest posts by dereklowe.bsky.social on Bluesky

Absolutely. Everyone with a working brain and a working heart is getting reallllly familiar with this feeling.

05.02.2026 17:21 — 👍 28    🔁 2    💬 2    📌 0

As many have said, the starting demand should be to totally abolish ICE. You work down from there. If you work down from this instead there won’t be much left.

05.02.2026 14:17 — 👍 29    🔁 3    💬 3    📌 0

These are all totally reasonable. My hope is that when the Republicans reject them - as they are very likely to - that Schumer and Jeffries just walk out until they’re met.

My fear is instead that they’ll use this list as a starting point and negotiate a lot of it away before caving.

05.02.2026 14:17 — 👍 24    🔁 5    💬 2    📌 0

We shouldn't put all "AI-based tools" in the same bag. Grammar editing, yes. Translation tools, yes. All with some checks. It's not the same as using GenAI to create text from prompts.

05.02.2026 13:27 — 👍 19    🔁 2    💬 1    📌 0

Farooq Sher is a papermilling fraudster at Nottingham Trent University in UK. He also runs a predatory conference scam. Farooq the Crook even sent lawyers to threaten me.
forbetterscience.com/tag/farooq-s...
forbetterscience.com/2022/10/17/n...

05.02.2026 06:38 — 👍 10    🔁 4    💬 1    📌 0

I would be very glad to see examples of this, if anyone knows of some.

05.02.2026 12:54 — 👍 9    🔁 2    💬 3    📌 0
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FDA Removes Warning Page About Dangerous Autism Treatments Autism researchers question motivations for latest HHS changes, including the new IACC

I am not exaggerating: Removing this webpage warning against fake autism "treatments" will kill autistic people.
www.medpagetoday.com/neurology/au...

05.02.2026 01:35 — 👍 793    🔁 409    💬 21    📌 24

I get to review journal articles sometimes. Can confirm, it’s getting pretty sloppy.

It astonishes me that people ask these things scientific questions at all. You should see what the citations look like in a paper generated by a plagiarism robot. Utterly worthless.

04.02.2026 23:15 — 👍 13    🔁 4    💬 0    📌 1
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First author Farooq Sher is well-known :) at least in the pubpeer crowd. Here is a collage from some of his best work! pubpeer.com/search?q=Far...

04.02.2026 21:09 — 👍 27    🔁 2    💬 7    📌 3

Bailed out of Twitter (as it was) a few years ago and ended up here!

04.02.2026 20:47 — 👍 0    🔁 0    💬 0    📌 0
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What the Literature is Filling Up With

Welcome, piles of slop filling up the journals with clouds of useless wordy garbage. Case in point:

04.02.2026 20:47 — 👍 80    🔁 35    💬 8    📌 9

Jeffrey Bezos is destroying the Washington Post for the same reason Musk destroyed Twitter and Ellison is destroying CBS—oligarchs oppose the free press when if it threatens their wealth and power.

They don’t want normal people to see what is happening in America.

04.02.2026 14:47 — 👍 13595    🔁 4277    💬 406    📌 198
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A Complex Cancer-Alzheimer's Connection

It seems that cancer has a preventative effect on Alzheimer's - but turning that phenomenon into something useful is not going to be straightforward:

04.02.2026 15:03 — 👍 30    🔁 3    💬 1    📌 1

This cannot be something a civilian law enforcement agent is allowed to wear in the US — and an agency that has a culture that tolerates this cannot be saved.

04.02.2026 00:53 — 👍 10422    🔁 3017    💬 272    📌 80

my two asks for electeds (reasonable ones, imo):

1) what can you demand in this current budget fight to free the hundreds of kids in DHS concentration camps?

2) will you pledge to dismantle DHS, abolish the paramilitaries, and close the concentration camps for good, once democrats are in power?

04.02.2026 00:52 — 👍 146    🔁 40    💬 2    📌 2

I don't know if non-lawyers understand how insane this statement is. I honestly can't think of anything remotely comparable in non-lawyer speak. I guess the closest would be a surgeon saying "Imagine if I had to wash my HANDS before doing surgery!"

03.02.2026 16:06 — 👍 1800    🔁 557    💬 66    📌 18
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BERNIE SANDERS: Do vaccines cause autism?

BHATTACHARYA: I do not believe that the measles vaccine causes autism

SANDERS: Nah. Uh uh. I didn't ask measles. Do vaccines cause autism?

BHATTACHARYA: I have not seen a study that suggests any single vaccine causes autism

03.02.2026 15:59 — 👍 26009    🔁 7154    💬 677    📌 371
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A ‘shadow CDC’ is scrambling to fill gaps in public health data Dozens of routinely updated CDC databases have gone quiet. Here’s what states and medical societies are doing to preserve U.S. public health

Under RFK, Jr., the CDC's authority has crumbled: it is no longer updating dozens of health databases, and has abandoned vaccine guidelines. But states and governors are trying to fill the void, @laurenjyoung.bsky.social writes @scifri.bsky.social: www.scientificamerican.com/article/stat...

03.02.2026 17:18 — 👍 123    🔁 56    💬 0    📌 3

I often wondered how the French aristocrats could be so clueless as to the danger their cruel indifference was putting them in before the French Revolution but now I get to watch the same thing in real time

03.02.2026 16:49 — 👍 68    🔁 13    💬 3    📌 1
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happening this morning in Minneapolis -- ICE agents drawing guns on observers. I reiterate again that it is only a matter of time before DHS kills more innocent people in Minnesota. Congress needs to shut this shit down right now.

03.02.2026 16:19 — 👍 43100    🔁 19319    💬 2402    📌 1620

I fully believe Trump will smash the authoritarianism button harder and harder as he feels the midterms wipe out approaching, I'm less sure that doing so will prevent or mitigate said wipe out

02.02.2026 19:49 — 👍 3620    🔁 333    💬 64    📌 24
A contents page showing chapters, each with a list of the topics that come up every few paragraphs.

A contents page showing chapters, each with a list of the topics that come up every few paragraphs.

“The Big Bonanza” (1876) by Mark Twain’s contemporary Dan DeQuille has this style:

03.02.2026 01:28 — 👍 2    🔁 0    💬 0    📌 0
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Did A.I. Take Your Job? Or Was Your Employer ‘A.I.-Washing’?

I'm glad I'm not the only one who was suspicious, re: Dow and AI-related layoffs

www.nytimes.com/2026/02/01/b...

02.02.2026 21:17 — 👍 22    🔁 5    💬 3    📌 0

The last time he started talking like this, his allies minimized the risks and we ended up with January 6. This time we must take him literally and seriously. These comments are a five-alarm fire for democracy. In a functioning republic, he would be impeached and removed from office today.

02.02.2026 21:04 — 👍 3556    🔁 1209    💬 95    📌 32
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The 2025 FDA Approvals

The 2025 FDA approvals: one count is holding up fine, another maybe not:

02.02.2026 20:21 — 👍 15    🔁 1    💬 1    📌 0
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Lysenkoism 2.0 continues: Podcast Jay wants to turn NIH into the “research arm” of MAHA NIH Director Jay Bhattacharya has recently said that he wants to transform the NIH into the "research arm of MAHA" and a "central driver of the MAHA agenda." Lysenkoism 2.0 continues apace at NIH.

NIH Director Jay Bhattacharya has recently said that he wants to transform the NIH into the “research arm of MAHA” and a “central driver of the MAHA agenda.” Lysenkoism 2.0 continues apace at NIH. sciencebasedmedicine.org/maha-podcast...

02.02.2026 15:14 — 👍 133    🔁 65    💬 9    📌 1

We're gonna keep doing The Work. We're going to tear down everything he builds, build back everything he tears down, and whatever day he dies will be a national holiday for centuries.

02.02.2026 00:00 — 👍 52    🔁 8    💬 1    📌 0

Other people: "Don’t ask me about my political opinions of the President, because I’d rather not answer."

Me to my daughter, yelling down from our house's roof: "If I die, tell your grandkids I hated Donald Trump."

01.02.2026 23:06 — 👍 83    🔁 12    💬 0    📌 1

Trump would like there not to be! But it’s not up to him, as a court ruling this week reminded him. Elections are run by the states.

They’ll try all the bullshit they can think of, though, for sure. Got to anticipate this and stay alert. . .

01.02.2026 16:46 — 👍 3    🔁 0    💬 0    📌 0

Yeah, this structure is basically too stupid to have been produced without genAI help, isn’t it?

01.02.2026 16:36 — 👍 15    🔁 0    💬 0    📌 0

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