Ayan Dhara

It’s so cool!

21.10.2025 13:38 — 👍 1    🔁 0    💬 1    📌 0

a large, fluffy pup sits on her human's lap outdoors. she's looking straight ahead while being held like a child. her feet are up and her toe beans are spread wide, presumably for tanning purposes.

This is Comoong. She has a whole dog park to run around in. Prefers to sit like this the entire time instead. 13/10 (IG: comoongpark)

20.10.2025 19:59 — 👍 4303    🔁 461    💬 64    📌 23

PhD position available in Experimental and Computational Organic Materials Discovery at Imperial College London on FindAPhD.com PhD Project - PhD position available in Experimental and Computational Organic Materials Discovery at Imperial College London, listed on FindAPhD.com

📣 PhD position now open for Oct 2026 start based at @imperialchemistry.bsky.social: tinyurl.com/PhDFDF. An interdisciplinary project combining experimental
& computational materials discovery in a collaborative Royal Society-funded team. Co-supervised by @beckylgreenaway.bsky.social.

15.09.2025 13:44 — 👍 13    🔁 13    💬 0    📌 0

Molecular glue degraders are more versatile than previously thought Study by biotech firm Monte Rosa finds that they can target a wider variety of proteins

More proteins may be druggable with molecular glue degraders than initially thought, according to a new paper in Science from the biotech firm Monte Rosa Therapeutics. cen.acs.org/pharmaceutic... #chemsky 🧪

04.07.2025 19:44 — 👍 26    🔁 7    💬 0    📌 0

Been listening to Radiohead lately - I’ve just noticed a line from the song Let Down is ‘Chemical reaction/ Hysterical and useless’ : Some days I do feel like this. ☺️

04.07.2025 19:05 — 👍 1    🔁 1    💬 0    📌 0

Sounds so interesting! I should have attended this conference. Since I work on tattoos, it would have been right up my alley.

26.06.2025 20:01 — 👍 0    🔁 0    💬 0    📌 0

Congrats, Miguel!

19.06.2025 14:50 — 👍 0    🔁 0    💬 0    📌 0

Sharing new breakthroughs and artifacts supporting molecular property prediction, language processing, and neuroscience Meta FAIR is sharing new research artifacts that highlight our commitment to advanced machine intelligence (AMI) through focused scientific and academic progress.

“Built with the high-performance quantum chemistry program package ORCA (Version 6.0.1), OMol25 contains simulations of large atomic systems that, until now, have been out of reach.” - Meta

#ORCAqc #ORCA6 #CompChem #QuantumChem #ML #Meta

ai.meta.com/blog/meta-fa...

arxiv.org/abs/2505.08762

15.05.2025 11:02 — 👍 8    🔁 2    💬 2    📌 2

A photograph of Louis Bamberger, seated on the right, wearing a mustache and bowler hat, and his sister Caroline Bamberger Fuld, standing on the left, wearing a fur hat and shawl

Let's talk about these two department store owners: brother and sister Louis Bamberger and Caroline Bamberger Fuld. From Newark, New Jersey.

They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵

14.05.2025 04:41 — 👍 4301    🔁 2050    💬 82    📌 361

Defluorination is Happening Inside You Right Now

People have occasionally found microbes that can actually break carbon-fluorine bonds, as unlikely as that may seem. What's even more surprising is that we have some of them in our own intestinal flora!

30.04.2025 20:14 — 👍 82    🔁 19    💬 5    📌 6

Final_Version_of_Tarrifs_actualFINALcopy_version7_USETHISONE.docx

09.04.2025 18:39 — 👍 23571    🔁 4933    💬 292    📌 240

Snow-covered Port Credit Memorial Park

A view of the Toronto skyline from Port Credit

Snow-covered tree branches

Snow-covered J.C.Saddington Park, Port Credit

A gorgeous snowy day in Port Credit

14.02.2025 00:40 — 👍 4    🔁 0    💬 0    📌 0

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

08.02.2025 21:21 — 👍 1014    🔁 856    💬 83    📌 32

It looks so pretty!

31.01.2025 17:21 — 👍 1    🔁 0    💬 0    📌 0

PhD projects available in a range of areas - something for everyone! Join us to do cool chemistry using the mechanical bond in catenanes and rotaxanes for real world applications in the shiny shiny new Molecular Sciences Building @uobchemistry.bsky.social 😊 Reposts appreciated! #chemsky

13.01.2025 10:00 — 👍 25    🔁 32    💬 1    📌 0

Interesting discussion! Though it is focused on computational chemistry, a similar discourse could happen in any other field of chemistry.

11.01.2025 19:56 — 👍 0    🔁 0    💬 0    📌 0

Sad news. I was fortunate to meet Sir Fraser during my postdoc at IU Bloomington in 2019. A brilliant scientist in our field. My heartfelt condolences to his family.

31.12.2024 17:17 — 👍 2    🔁 0    💬 0    📌 0

Programming the Kinetics of Chemical Communication: Induced Fit vs Conformational Selection Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging from microseconds to days. The ability to similarly program and control the kinetics of artificial switches would greatly assist the design and optimization of future chemical and nanotechnological systems. Two distinct structure-switching mechanisms are typically employed by biomolecular switches: induced fit (IF) and conformational selection (CS). Despite 60 years of experimental and theoretical investigations, the kinetic and evolutive advantages of these two mechanisms remain unclear. Here, we have created a simple modular DNA switch that can operate through both mechanisms and be easily tuned and adapted to characterize its thermodynamic and kinetic parameters. We show that the fastest activation rate of a switch occurs when the ligand is able to bind its inactive conformation (IF). In contrast, we show that when the ligand can only bind the active conformation of the switch (CS), its activation rate can be easily programmed over many orders of magnitude by a simple tuning of its conformational equilibrium. We demonstrate the programming ability of both these mechanisms by designing a drug delivery vessel that can be programmed to release a drug over different time scales (>1000-fold). Overall, these findings provide a programmable strategy to optimize the kinetics of molecular systems and nanomachines while also illustrating how evolution may have taken advantage of IF and CS mechanisms to optimize the kinetics of biomolecular switches.

Have a look at the TOC graphic - Nice and simple design but also fairly self-explanatory. Love it!

pubs.acs.org/doi/10.1021/...

19.12.2024 16:17 — 👍 1    🔁 0    💬 1    📌 0

a white fleece blanket with black spots is puddled up on a light-beige chair. part of the blanket seems to rise up from the seat, defying gravity, as if it’s propped up on something. some of the spots near the top are irregular, resembling two eyes (one brown and one blue) and a black nose on a dalmatian’s face.

Haha very funny guys. Sending in photos without dogs in them. Thought we just wouldn’t notice? Hilarious. Still 12/10 for the blanket

11.12.2024 21:57 — 👍 9153    🔁 637    💬 81    📌 24

Photo of a Christmas tree in Port Credit Memorial Park, with the Port Credit lighthouse visible in the background on a snowy evening

Photo of Port Credit Memorial Park in the evening of a snowy day

My smiling picture, with a Christmas tree and the port credit lighthouse visible in the background, in the Port Credit Memorial Park on a snowy day

A beautiful snowy afternoon in Port Credit

08.12.2024 03:14 — 👍 0    🔁 0    💬 0    📌 0

An article which challenges the conventional wisdom - definitely worth adding it to your reading list

30.11.2024 20:44 — 👍 1    🔁 0    💬 0    📌 0

A nice collection of interesting books on inorganic chemistry!

27.11.2024 22:21 — 👍 1    🔁 0    💬 0    📌 0

I am Ayan, a chemist working on the design and synthesis of new inks for semipermanent tattoos in Toronto. Looking forward to connecting with interesting people and learning about cool discoveries in chemistry.

25.11.2024 03:36 — 👍 5    🔁 0    💬 0    📌 0