Alexander Pöthig

From @apoethig.bsky.social,‬ [2]rotaxanes with enhanced reactivity (@jacs.acspublications.org).

These rotaxanes were shown to deprotect faster compared to non-interlocked structures due to conformational preorganisation.

🔗 CSD Entry XAJJEC: dx.doi.org/10.5517/ccdc...

#FeaturedStructureFriday

Spotlight on Mechanosterics: A Bulky Macrocycle Promotes Functional Group Reactivity in a [2]Rotaxane Macrocycles typically hinder the reactivity of adjacent functional groups in mechanically interlocked molecules due to steric shielding. Herein, we report a [2]rotaxane in which a bulky macrocycle in ...

Thrilled to share our new @J_A_C_S paper: A bulky macrocycle enhances (not hinders!) functional group reactivity in a [2]‑rotaxane. Including definition and rationalization of this positive mechanosteric effect.
📖 pubs.acs.org/doi/10.1021/...
#Rotaxanes #JACS

Endohedral Coordination of Bulky Substrates in Metalloenzyme‐like Organometallic Nanotubes Artificial receptors inspired by metalloenzymes share three key properties: a structurally flexible cavity, substrate binding via metal–ligand coordination, and metal-based redox activity. Herein, we...

Thrilled to share that after more than five years of fascinating yet complex research, our article on Metalloenzyme-like Organometallic Nanotubes is out!

A huge thank you to my brilliant co-authors, collaborators, and everyone who contributed to this journey.

#Supramolecular #Organometallics