Monitoring monomer-specific acyl–tRNA levels in cells with PARTI Abstract. We describe a new assay that reports directly on the acylation state of a user-chosen transfer RNA (tRNA) in cells. We call this assay 3-Prime Ad

✨ New C-GEM Breakthrough Article in @narjournal.bsky.social

Monitoring monomer-specific acyl–tRNA levels in cells with PARTI

Congratulations to Meghan, @carlyschissel.bsky.social, Izzy, Cameron, and Alanna!

academic.oup.com/nar/article/...

I am recruiting at all levels for my new Peptide Chemical Biology group launching at Penn State Chemistry in the fall! We'll use molecular biology, synthetic chemistry, and computational tools. If you or someone you know is interested in a postdoctoral or lab tech position, please reach out!

Both Trp and Pro (along with Gly, Ala, Phe, Val, & Glu) worked as well! I think having something with large steric bulk next to the ester would slow the rearrangement, but these canonical residues allowed for near-full to full conversion. Thanks for asking!

Peptide Backbone Editing via Post-Translational O to C Acyl Shift Despite tremendous efforts to engineer translational machinery, replacing the encoded peptide backbone with new-to-nature structures remains a significant challenge. C, H, O, and N are the elements of...

Hello Bluesky! Excited to join and share my postdoc work with Alanna Schepartz, Matt Francis and @cgemcci.bsky.social now out in JACS: Peptide Backbone Editing via Post-Translational O to C Acyl Shift. Proud of our team of undergrad & early grad students—Check it out!
pubs.acs.org/doi/10.1021/...