Clay Wright

We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & ‪@plants4space.bsky.social‬. Apply: bit.ly/3GKSRSA

ExPOSE: a comprehensive toolkit to perform expansion microscopy in plant protoplast systems This method provides a robust approach for performing expansion microscopy in plant protoplasts for imaging single-cell and subcellular compartments at greatly enhanced resolution.

Some of my postdoc work has been "exposed" today in @theplantjournal.bsky.social! 😁🎉🔬 We developed ExPOSE - a method to perform expansion microscopy in plant protoplast systems. Here's a quick🧵of the details: @meter76.bsky.social @lily-oconnor.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...

NIH cuts billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.

www.washingtonpost.com/health/2025/...

Joanne Cohn and the email list that led to arXiv A strong sense of community led an early-career string theorist to share preprints in a scientifically competitive environment.

'Before there was arXiv, there was Joanne Cohn (...) She started an informal exchange of string theory manuscripts that eventually became the arXiv preprint server, which has since revolutionized the way scientists share ideas and announce findings.'

pubs.aip.org/physicstoday...

Nope, not in my group, but I definitely feel like I have reviewed some manuscripts and proposals like this.

Last update of our databases for the year.

Download them here:

493 early-career funding opportunities: research.jhu.edu/rdt/funding-...

313 postdoc fellowships: research.jhu.edu/rdt/funding-...

189 PhD fellowships: research.jhu.edu/rdt/funding-...

A function of TPL/TBL1-type corepressors is to nucleate the assembly of the preinitiation complex Corepressors in the TPL/TBL1-type family prime genes for rapid activation by facilitating assembly of the transcription preinitation complex, including TFI

Excited to share our recent study is out at the Journal of Cell Biology! @jcellbiol.bsky.social, LisH domains are short but powerful domains in priming transcription by corepressors: doi.org/10.1083/jcb..... Very proud of our NemLab team!!

Do a predoc, young people What’s the rush in starting a PhD? Why don’t you instead do a predoc before committing to doctoral studies.

We're looking for a predoc in molecular evolution. Basic computational skills desired. Minimum 1 year. Send me DM.

Wanna know what a predoc is? Check👇 medium.com/age-of-aware...

On to Part 2 of the Synthetic Biology (SynBio) starter pack.

Part 1: bsky.app/starter-pack...
Part 2: bsky.app/starter-pack...

Reply or DM to add/nominate.

I would love to be on this list too! Thanks for building community here!

Rapid in silico directed evolution by a protein language model with EVOLVEpro Directed protein evolution is central to biomedical applications but faces challenges like experimental complexity, inefficient multi-property optimization, and local maxima traps. While in silico met...

A really nice application of pre-trained PLMs and supervised modeling for efficient directed evolution - a few different protein types too!

preprint version as well: www.biorxiv.org/content/10.1...

www.science.org/doi/10.1126/...