Dr Taylor Szyszka

So excited that this is out in the world! Onto the next phase 🦠🧪

30.10.2025 23:15 — 👍 2    🔁 0    💬 0    📌 0

Would love to see some friendly faces in the crowd! Get your tickets below 👇

11.03.2025 23:59 — 👍 2    🔁 0    💬 0    📌 0

Thanks, Kovi! And thanks for including the emoji - I'm still learning the ropes! 😂

12.12.2024 23:36 — 👍 1    🔁 0    💬 1    📌 0

You misspelled pumpkin pie

12.12.2024 20:47 — 👍 0    🔁 0    💬 0    📌 0

Decorating your Christmas tree? Try these crafts inspired by Aussie plants and animals Let’s cast the holly, snowmen and reindeer aside to decorate our homes with Aussie Christmas crafts instead. How about Christmas beetle baubles, paper parrots and ornamental echidnas?

Being from the USA, I struggle with Aussie Christmas. Maybe all I've been missing is some Aussie Christmas flair? My glorious friends @bambiraptorf.bsky.social @astrolaura.bsky.social and Prof Euan Ritchie wrote a great piece about science and Christmas crafts! theconversation.com/decorating-y...

12.12.2024 20:30 — 👍 8    🔁 0    💬 2    📌 0

This paper is also special because it's my first work co-authored by my better half @rezwansiddiquee.bsky.social! Many thanks to Lau Group members Alex, Lachlan, Titus, and Regi as well as UTS colleagues Andrew and Claire. And and all thanks to my supervisor @yuhenglau.bsky.social for his support!

27.11.2024 00:49 — 👍 1    🔁 0    💬 0    📌 0

The biggest advantage of this system is how darn easy it is to use. It's entirely modular with the cargo only needing a short CLP attached to direct packaging. This system removes a significant barrier in encapsulin biotechnology - we can't wait to see where we go from here!

27.11.2024 00:49 — 👍 3    🔁 0    💬 1    📌 0

a schematic showing that if the fusion protein is cleaved in the presence of cargo molecules, the cargo ends up inside the assembled cage structures

If you cleave the protein the the presence of molecule fused to a a cargo-loading peptide (CLP), the cages will package the cargo molecule with minimal losses. We show the packaging of a fluorescent protein, synthetic dye, and cancer drug molecule.

27.11.2024 00:49 — 👍 2    🔁 0    💬 1    📌 0

microscopy images showing unassembled proteins with the fusion attached and uniform, circular assemblies after cleaving the fusion protein

By fusing the encapsulin monomer to a steric block, we prevent in vivo assembly and can purify stable, soluble unassembled encapsulin! Cleaving off the fusion leads to robust assemblies which are higher fidelity and more stable than their in vivo counterparts

27.11.2024 00:49 — 👍 4    🔁 0    💬 1    📌 0

High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages Cargo-filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can be packa...

My first ever Bluesky post is a new #preprint alert! What if we could put *anything* into a protein cage? Our new in vitro encapsulin assembly system is esay to use and enables the pacakging of protein and synthetic cargo!
www.biorxiv.org/content/10.1...

27.11.2024 00:49 — 👍 19    🔁 4    💬 1    📌 1

High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages Cargo-filled protein cages are powerful tools in biotechnology with demonstrated potential as catalytic nanoreactors and vehicles for targeted drug delivery. While endogenous biomolecules can be packa...

Very excited to share our new pre-print! We’ve developed a new way to put any type of cargo (biological or synthetic) into protein cages! All in-vitro! This enables massively scalable in vitro packaging technology for multiple lucrative applications. www.biorxiv.org/content/10.1...

26.11.2024 05:32 — 👍 11    🔁 3    💬 1    📌 0

Long time lurker, first time poster... announcing our latest preprint on encapsulin protein cages!

We can now assemble them beautifully in vitro, without the ugly defects you get using acid/base or denaturants.
This lets us put any synthetic cargo into these cages.

www.biorxiv.org/content/10.1...

26.11.2024 04:12 — 👍 37    🔁 8    💬 4    📌 2