Jakub Ruszkowski

Summary #GlomCon

American Society of Nephrology Kidney Week 2025 Original Article | Nov. 7, 2025 | NEJM.org Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis Fig. 1A. A Serious Cardiovascular Events The NEJM identity sits at the bottom.

In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo

@asnkidney.bsky.social | #KidneyWk

Empagliflozin, the kidney, and what we still don’t understand — NephJC NephJC short on an empagliflozin meta-analysis

The latest empadata dump: @nephroseeker.medsky.social writes up a #NephJC short on the meta analysis

www.nephjc.com/news/2025/10...

Seeking collaboration with #MedLibs for scoping review on predictive models in peritoneal dialysis!
Protocol nearly finalized. Looking for expertise in search strategy peer-review (PRESS checklist) + optional database searches/deduplication.
DM if interested in co-authorship for this project!

Lots of different ways to do observational causal inference—IV, proximal inference, etc. What if you could compare those strategies more directly?

New preprint w/ @melodyyhuang.bsky.social tries to do just that. Here's one cool figure—we're able to visualize bias of 3 estimators on the same plot

"It remains important to consider bromism in patients presenting with new neurologic, psychiatric, and/or dermatologic symptoms, as well as hyperchloremia
with a negative anion gap." (...) Elevated levels of halides such as bromide falsely increase chloride reading.

Urine sodium (Urine Na) levels post-saline infusion in differentiating non-edematous hyponatremia ca. 2025
#Nephpearls #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/40775013/

modelbased: An R package to make the most out of your statistical models through marginal means, marginal effects, and model predictions Makowski et al., (2025). modelbased: An R package to make the most out of your statistical models through marginal means, marginal effects, and model predictions. Journal of Open Source Software, 10(1...

#statstab #390 modelbased: An R package to make the most out of
your statistical models through marginal means,
marginal effects, and model predictions

Thoughts: Great package for getting predicted probabilities for your models.

#rstats #r #easystats

doi.org/10.21105/jos...

The Double-Icodextrin Dose Randomized Controlled Trial of a Double #Icodextrin Dose for #Older Patients on Incremental Continuous Ambulatory Peritoneal Dialysis #CAPD

#VisualAbstract by @md_abdulqader83

www.kireports.org/ar...

@lobbedezt.bsky.social @clemencebechade.bsky.social

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?

That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience

A 🧵 1/n

[Skim] KI-Tools für die wissenschaftliche Literaturrecherche: Potenziale, Problematiken, Didaktik und Zukunftsperspektiven www.degruyterbrill.com/document/doi... - or AI Tools for Academic Literature Search: Possibilities, Problems, Didactics, and Future Prospects insanely comprehensive! (1)

Next level of cherry-picking. Lack of significance in Student's t-test? Report then F-test and interpret it as a t-test 🫣🫣🫣

(F-test compares variances, not means🤡)

Source: doi.org/10.3390/cell...

#Statistics thought of the day: Need power calculations for a 2-group comparison on an ordinal or continuous response variable Y with/without clumping at a specific value (e.g., 0) of Y, with a possibly bimodal, heavy tailed, or skewed distribution? See www.fharrell.com/post/pop/ #RStats #StatsSky

CLINICAL IMPACT:
Current CKD staging doesn't account for proximal tubular damage - a key risk factor for hypomagnesemia in CKD patients. 💊 Mg supplementation showed limited efficacy in proteinuric patients

Read more: doi.org/10.1093/ndt/...
🧵3/3

KEY FINDINGS:
🔍 Proteinuria = higher probability of hypo-Mg (OR 2.2; 95% CI 1.2–4.0), especially in non-diabetics
📈 Higher proteinuria (uPCR) → higher urinary Mg excretion (FE-Mg)
🧪 When proximal tubular markers were included in analysis, the uPCR-FEMg association weakened significantly

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HYPOMAGNESEMIA IN CKD - Renal Magnesium Wasting

While CKD typically causes hypermagnesemia due to ↓GFR, researchers from Osaka University found that ~15% of CKD patients paradoxically develop hypomagnesemia instead.
academic.oup.com/ndt/article/...
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#NephSky #Nephrology

Fecal microbiota transplantation from patients into animals to establish human microbiota-associated animal models: a scoping review Journal of Translational Medicine

A Review published in the Journal of Translational Medicine gives an overview of the current state of research using human-to-animal fecal microbiota transplantation to elucidate the role of the gut microbiota in the pathophysiology of noninfectious diseases and traits.

#MedSky

Thanks for sharing! ☺️ I have to admit, my enthusiasm faded when I kept discovering—often buried deep in the manuscript or hidden in the supplements—that their “groundbreaking” findings were based on FMT from a single donor. 🤦‍♂️ The field suffers from weak methodology and poor reporting standards.

Fecal microbiota transplantation from patients into animals to establish human microbiota-associated animal models: a scoping review - Journal of Translational Medicine Background Fecal microbiota transplantation (FMT) from humans with specific medical conditions to animal models can demonstrate causality by inducing or exacerbating pathophenotypes, linking the gut m...

This field is exploding with potential! 🚀 But we need better methods and reporting to truly understand the gut-disease connection.

Hope you find this work (~ 2 years) interesting and helpful in your research!

🔎5/5

Our recommendations for better research (short version):
1️⃣ Follow GRAFT guidelines (adapted for human→animal FMT)
2️⃣ Use multiple donors
3️⃣ Include both sexes (if possible)
4️⃣ Verify microbiota colonization
5️⃣ Comprehensive outcome assessment
6️⃣ Transparent reporting

🔎4/5

MAJOR finding: Huge methodological gaps! 📋
🔸 Many studies use single donors (big generalizability problem!)
🔸 86% of studies don't report donor medications
🔸 Methods vary wildly (fresh vs frozen samples, different volumes)
We need standardization!
🔎3/5

What we found:
🔸 IBD, IBS, obesity, colorectal cancer & depression = most studied health issues
🔸 Cancer research focuses heavily on the non-responsivness to immunotherapy
🔸 Cardiovascular and renal outcomes are surprisingly understudied! 💔
🔎2/5

Fecal microbiota transplantation from patients into animals to establish human microbiota-associated animal models: a scoping review - Journal of Translational Medicine Background Fecal microbiota transplantation (FMT) from humans with specific medical conditions to animal models can demonstrate causality by inducing or exacerbating pathophenotypes, linking the gut m...

We just published the largest scoping review on fecal microbiota transplantation (FMT) from human patients to animals! Our team analyzed 489 studies that tried to go beyond showing CORRELATIONS between gut bacteria and disease, and focused on FMT from patients to animals to prove causality! 🔬

🔎1/5

#statstab #363 p-checker The one-for-all p-value analyzer

Thoughts: Easy way to check for publication bias using some current tools.

#shiny #pvalue #phacking #QRPs #zcurve #bias #pcurve #rindex

shinyapps.org/apps/p-check...

When should a Nephrologist suspect a mitochondrial disease? | Nefrología Mitochondrial diseases, taking into account those that affect the processes of the respiratory

"Maternally inherited diabetes and deafness is one of the most common mitochondrial diseases. (...) In all three cases, the symptoms were similar: diabetic patient, with hearing loss and renal involvement, non-nephrotic proteinuria and sediment without microhaematuria."

While slowing eGFR decline would be a major win, I'm struggling to see a pathophysiological basis for an increase in eGFR. Sclerosed glomeruli will not resume function. Seems we must rule out either decreased creatinine production or hyperfiltration as confounders before calling it remission.

BakRep – a searchable large-scale web repository for bacterial genomes, characterizations and metadata www.microbiologyresearch.org/content/jour... 🧬🖥️ Nextflow code: github.com/ag-computati...

Recovery of Tenofovir-induced Nephrotoxicity following Switch from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Human Immunodeficiency Virus-Positive Patients - PubMed Tenofovir-induced nephrotoxicity in HIV-positive patients receiving TDF was mostly reversible after changing to TAF. Thus, TAF-containing regimens can be administered safely to HIV-positive patients w...

Tenofovir-induced tubulopathy can be avoided by using tenofovir alafenamide instead of tenofovir disoproxil fumarate. I would gladly offer it to my patients with chronic hepatitis B, but unfortunately, in Poland, this formulation is available only in combination with other drugs for HIV.

Hearing loss and renal syndromes - Pediatric Nephrology The association between ear and kidney abnormalities has long been recognized; however, the connection between these two disparate organs is not always straightforward. Although Alport syndrome is the...

Alport-like syndrome with thrombocytopenia? Think about MYH9-related disorders (Epstein syndrome, Fechtner syndrome, May–Hegglin anomaly, and Sebastian syndrome). MYH9 is the gene encoding nonmuscle myosin IIA.

link.springer.com/article/10.1...