Global TB Program

Improved Detection of Extrapulmonary and Paucibacillary Pulmonary Tuberculosis by Xpert MTB Host Response in a Tuberculosis Low-Endemic, High-Resource Setting The Xpert MTB Host Response (MTB-HR) assay has reached World Health Organization (WHO) test targets for pulmonary tuberculosis (PTB) with high bacillary loads.

Improved Detection of Extrapulmonary and Paucibacillary Pulmonary Tuberculosis by Xpert MTB Host Response in a Tuberculosis Low-Endemic, High-Resource Setting

#IDSky

Estimating the Early Transmission Inhibition of New Treatment Regimens for Drug-Resistant Tuberculosis Most drug-resistant tuberculosis occurs due to transmission of unsuspected or ineffectively treated drug-resistant tuberculosis.

Estimating the Early Transmission Inhibition of New Treatment Regimens for Drug-Resistant Tuberculosis

#IDSky

Research opens up new avenue for Tuberculosis drug discovery Researchers investigating the structure and function of the TB enzyme MCR have identified several possible new drug candidates for treating TB.

University of Bath scientists have found potential doorways to new treatments for #tuberculosis (TB).

Researchers studied a bacterial enzyme which helps the bacteria use cholesterol as an energy source. Blocking this enzyme can starve bacteria and help treat infections.

#Research

Xpert MTB/RIF Ultra assay for pulmonary tuberculosis and rifampicin resistance in adults and adolescents - PubMed Generic protocol available on Open Science Framework via https://osf.io/26wg7/wiki/home/. Previous protocol and review versions available via DOI 10.1002/14651858.CD009593 and DOI…

🚨Publication Alert🚨
The Xpert MTB/RIF Ultra, a WHO-endorsed rapid molecular diagnostic tool, excels in identifying tuberculosis and rifampicin resistance. This review updates the comparative accuracy of Xpert MTB/RIF and its successor, Xpert Ultra. buff.ly/zSfhhe0
Congrats to all contributors👏

August is #NationalBreastfeedingMonth. The theme for #NBM is "Forward Together," emphasizing collaboration and support to promote breastfeeding. Did you know #breastfeeding can help protect against #TB in infants? Breast milk contains antibodies that can help prevent TB transmission. #TBawareness

TB elimination in Southern Africa: overview and critical reflection - PubMed Despite significant progress, TB remains a major public health challenge in Southern Africa. We highlight the key initiatives in Eswatini, Mozambique and South Africa, which have implemented various…

🚨Publication Alert🚨
#TB is a significant health issue in Southern Africa. Effective care requires outreach, training, identifying undiagnosed cases, and better treatment adherence with affordable solutions, political commitment, and community support. buff.ly/wtsMPTE
Congrats to all contributors 👏

🔬 New in The Lancet Infectious Diseases! CLIME & collaborators highlight how to care for those exposed to MDR/RR-TB.
Key takeaways:
✅ Levofloxacin cuts TB risk ~60%
✅ Tuberculosis preventive treatment works
✅ Support & nutrition matter
📌 Read: doi.org/10.1016/S147...
#MDRTB #TBprevention #EndTB

Tuberculosis Tuberculosis is a leading cause of death globally. Given the airborne transmission of tuberculosis, anybody can be infected, but people in high-incidence settings are more exposed. Risk of progression...

When a person is diagnosed with #tuberculosis, one of their first questions is often, “Why did I get tuberculosis? Why me?” 💬

Explore a Seminar which aims to help healthcare providers identify those at risk of TB & address patient concerns: tinyurl.com/zb2bwces

#Hepatitis and #TB can both lead to severe liver damage and be debilitating diseases, but with proper care, they can be prevented and treated. #WorldHepatitisDay #tuberculosis #prevention #treatment

#ParentsDay is a special day to honor all the hard work and dedication that parents put into raising their children. Providing support for parents living with #tuberculosis can improve health outcomes for their children. #EndTB #parenting #health

Ecological Factors Influencing Tuberculosis in Indonesia: Exploring the Interplay of Health Resources, Socioeconomic Status, Climatic Factors, and Consumption Patterns | Journal of Population and Social Studies [JPSS] The elimination of tuberculosis (TB) in Indonesia is a challenging task due to its persistent increase in incidence, making it one of the primary infectious diseases that cause death. Until now, its…

#ClimateChange is impacting not only our environment but also our health. This study provides an overview of various ecological factors that influence TB cases in Indonesia, offering insights for evidence-based policies to achieve TB elimination by 2030.

Decentralising TB diagnosis and contact management: impact on det...: Ingenta Connect

🚨Publication Alert🚨
The 'CaP-TB' initiative improved pediatric TB care by decentralizing services and introducing a 3-month rifampicin-isoniazid regimen for #TPT. This approach effectively addresses barriers to TB detection and TPT coverage in children. buff.ly/fMaeGrj
Congrats to all contributors👏

Sanitariums and Stigma: When TB Was Common in the U.S.

A great reminder that the U.S. TB epidemic remains within living memory: www.nytimes.com/2025/07/21/h...

Post-TB Community Call: Prof. Lisa Obimbo | Post-TB Community

On behalf of the TB Sequel consortium, PostTB Care & The Union, we’re delighted to invite you to the next Community Call on "Post-TB lung disease in children & adolescents, insights from an African perspective" by Prof. Lisa Obimbo

Wednesday, 10 September 2025
14:00–15:00 SAST

#Tuberculosis #PTLD

Tuberculosis bacteria ‘play dead’ to beat vaccines A new genetic study in mice reveals how Mycobacterium tuberculosis survives in vaccinated or previously infected hosts. New research finds tha...

#Health #and #Medicine #bacteria #tuberculosis #vaccines

Origin | Interest | Match

Plasma proteomics for biomarker discovery in childhood tuberculosis - Nature Communications In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.

We need new biomarkers to improve TB diagnosis in children. In the COMBO study, we performed a comprehensive plasma proteomic analysis across 4 countries and found several protein signatures that met the WHO target accuracy for a TB screening test: www.nature.com/articles/s41...

#tbsky #idsky

Research Roundup: AI-powered malaria drug discovery, Shortened TB treatment trial, Open-source molecular assay In today's Research Roundup for July 21, 2025, we highlight some of the most interesting reads in global health research and development from the past week.

Results from a multi-country Phase 3 clinical trial published last week found that a shorter all-oral drug regimen was effective in some patients with pre-extensively drug-resistant #tuberculosis but with mixed results.

www.ghtcoalition.org/blog/researc...

A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in mice - npj Vaccines npj Vaccines - A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in mice

A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium #tuberculosis in mice www.nature.com/articles/s41... (open access)

Join us on Thursday, 22 July, 7 am CT for a TB GAPS webinar on TB and Cardiovascular Disease presented by Dr. Andrew DiNardo and Dr. Moises Huaman! This webinar will explore the growing body of evidence linking tuberculosis to increased cardiovascular risk.

Register here: buff.ly/IpK0ret

#TBSky

Today we celebrate Nelson Mandela and his commitment to human rights. We honor his legacy by taking action against #TB - an illness that Mandela himself battled - to make sure everyone can access the treatment & care they need. #NelsonMandelaDay #MandelaDay

🚨Publication Alert 🚨
Monitoring TB treatment is challenging without a rapid biomarker. Stool qPCR offers faster results, is easy to collect, and identifies drug resistance, complementing sputum culture. buff.ly/9xCjbbB
Congrats to all contributors 👏

#DYK Extrapulmonary #TB is a form of #tuberculosis that affects areas of the body other than the lungs and is more common in #children and people with weakened immune systems. Early detection is key to successful treatment and prevention of long-term complications. #PublicHealth #infectiousdisease

Exploring diabetes self-management practices among people with TB in Eswatini: a qualitative analysis - PubMed Diabetes mellitus (DM), prevalent globally among individuals with tuberculosis (TB) and associated with suboptimal TB treatment outcomes, is a major concern in Eswatini, where high TB incidence and…

🚨 Publication alert🚨
Diabetes mellitus affects global health and TB treatment outcomes. In Eswatini, where TB is prevalent, assessing DM self-management is essential. This study reveals awareness of needs, but financial issues hinder effective management. buff.ly/qH12E3U
Congrats to all contibutors👏

🚚 From specimen transport in Pakistan to hub-and-spoke in Nigeria to digital tools in Kenya — efficiency saves lives (@GlobalFund).

Join us July 15, 8:00 AM EST for a webinar on TB care & private sector innovation.

🔗 Register: us02web.zoom.us/webinar/regi...
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This is, truly, an astonishing work of genius. To learn (much) more about TB, watch this video.

Everyday in SA, 832 people get TB and 153 die from it. This highlights the need to scale up testing in communities, improve access to treatment and tackle stigma that keeps people from seeking care. Read more on our 2024 State of TB Report here: bit.ly/4kKvve1
#endTB

🚨 Don’t miss our webinar on Private Sector Engagement & Efficiency in TB Care!

Learn how Kenya, Pakistan, Nigera, Philippines sustain TB services despite funding cuts—using partnerships, tech & innovation (TheGlobalFund).

📅 Save your spot! us02web.zoom.us/webinar/regi...

#EndTB #PrivateSectorTB

"Operational mechanisms engaging private providers increase TB prevention and care in Pakistan: The private sector is the preferred choice for over 90% of people accessing TB care. Offering patient-centered TB care services at the primary care level, Pakistan has engaged individual general practitioner practices and specialists in their PPM models for decades. In 2023, over 13,000 private healthcare providers, 500 hospitals, and 700 laboratories across 120 districts nationwide were involved, with private providers contributing more than 40% of the total country’s TB case notifications. The PPM models have improved access to WHO-recommended rapid diagnostics (WRDs) through outreach camps and a robust specimen transportation system involving over 600 community volunteer riders." Read more: - https://resources.theglobalfund.org/media/tslodd32/cr_private-sector-engagement-tb-care_report_en.pdf - https://www.sciencedirect.com/science/article/pii/S2405579424000937

🚨 Join us July 15 at 8:00 AM EST for a webinar on Programmatic Efficiency: Private Sector Engagement in TB Care

📢 Learn how @mercycorps.bsky.social Pakistan is using effective sample transportation to scale impact #EndTB

🔗 Register: us02web.zoom.us/webinar/regi...

#TBcare #PrivateSectorInTBcare

A picture of Vidya Krishnan and her book cover, Phantom Plague. "LIVE Q&A. FRIDAY JULY 18TH 11AM EDT. VIDYA KRISHNAN"

Get ready for a #TBReaders Q&A! We'll be talking with #PhantomPlague author, Vidya Krishnan, a week from today on Fri July 18, 11am ET/8am PT. Head to the TBReaders discord to submit your questions: tbfighter.link/tbrea...

TB or not TB: That depends on the antibody Fc Fc-swapped variant monoclonal antibodies reveal new mechanisms underlying Mycobacterium tuberculosis restriction.

As paper titles involving TB go, this one using the rhyming Fc is not bad...

(also a good synopsis of an important paper)
#IDSky #TBSky #immunosky

www.science.org/doi/10.1126/...