UCL Queen Square Institute of Neurology

2025 has been an innovative year at UCL. As the year draws to a close, we’ve been reflecting on some of the ways UCL Innovation & Enterprise has been supporting the UCL community make an impact through knowledge exchange and innovation.

Read: bit.ly/3K8UxXZ

@ucl.ac.uk @uclnews.bsky.social

It’s inspiring to see how UCL is transforming lives through #KnowledgeExchange and we’re proud to play our part!

Highlights include:
🧬 Advanced Therapies Symposium
🧬 Partnership enabling UK approval of first treatment for Friedreich’s ataxia
Explore more: bit.ly/3K8UxXZ

@uclenterprise.bsky.social

What an incredible year it has been! From major awards and grants to important research breakthroughs – UCL Queen Square Institute of Neurology's commitment to translating world-leading discovery science into meaningful impact for individuals worldwide is at the heart of our work.

UCL joins global effort to develop treatments for rare neurodevelopmental disorder Researchers at UCL Queen Square Institute of Neurology have joined forces with three leading organisations to accelerate research and potential treatment options for Coffin-Siris syndrome.

Researchers at @uclqsion.bsky.social have joined forces with three leading organisations to accelerate research and potential treatment options for Coffin-Siris syndrome.

Join us on Weds (3 Dec) to explore UCL’s new Sustainability Plan, hear inspiring climate action stories, and find out how you can make a difference. Panel discussion and Q&A with senior leaders. #GreenUCLPALS

👉 Find out more & register here: www.ucl.ac.uk/news/2025/no...

#BrainMeeting 🧠 Alert! 🎺

This Friday, December 5th, the Brain Meeting speaker will be Andrew MacAskill giving a talk entitled "A role for ventral hippocampus in hidden state inference"

In person or online. For more information:
www.fil.ion.ucl.ac.uk/event

Thank you to everyone at UCL Queen Square Institute of Neurology our collective efforts have made remarkable advances in bringing neuroscience from bench to bedside. We’ll be sharing highlights over the next few days.

ION Annual review 2024-25 cover

Today we publish our annual review, celebrating a year of outstanding translational progress, innovative partnerships, and dedication from our inspiring community of researchers, clinicians, students, and professional services staff. www.ucl.ac.uk/brain-scienc...

Advances in new biomarkers for dementia with Lewy bodies could transform diagnosis and care A new review, led by researchers at Queen Square Institute of Neurology, outlines how cutting-edge biomarkers could enable earlier, more accurate diagnosis and treatment of dementia with Lewy bodies.

A new review, led by researchers at @uclqsion.bsky.social, outlines how cutting-edge biomarkers could enable earlier, more accurate diagnosis and treatment of dementia with Lewy bodies.

Pioneering UCL Huntington’s researcher wins major neuroscience award Professor Sarah Tabrizi, Director of the UCL Huntington’s Disease Centre, has been awarded the British Neuroscience Association (BNA) Outstanding Contribution to Neuroscience Award for 2025, the…

🏆 1/ Professor Sarah Tabrizi, Director of the UCL Huntington’s Disease Centre (@ucl-hd.bsky.social), was awarded the British Neuroscience Association Outstanding Contribution to Neuroscience Award for 2025, the association’s top annual prize.
www.ucl.ac.uk/news/2025/no...

New brain atlas offers unprecedented detail in MRI scans A new AI-assisted brain atlas that can help visualise the human brain in unprecedented detail has been developed by UCL researchers, in a major step forward for neuroscience and neuroimaging.

🧠 4/ A new AI-assisted brain atlas that can help visualise the human brain in unprecedented detail has been developed by UCL researchers, in a major step forward for neuroscience and neuroimaging.
www.ucl.ac.uk/news/2025/no... @uclqsion.bsky.social

Rare Dementia Support Centre Operations Manager Centre Manager role at the Rare Dementia Support Centre in London supports operations and events and works with the team to deliver specialist services.

Centre Manager role at the Rare Dementia Support Centre in London supports operations and events and works with the team to deliver specialist services. Closing date: 17th December

www.dementiaresearcher.nihr.ac.uk/job/rare-dem...

🧵/ November was packed with breakthroughs and stories from UCL Faculty of Brain Sciences! Here’s your monthly roundup of research, awards, and achievements 👇
@uclpals.bsky.social @uclpsychiatry.bsky.social @uclqsion.bsky.social @ucleye.bsky.social

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Check out the October 2025 edition of the #HD Clinical Trials Update, now published in the Journal of Huntington's Disease and available online! 🔗 journals.sagepub.com/doi/10.1177/... @profwild.bsky.social @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social

Wonderful Annual Address lecture from Prof Dame Ijeoma Uchegbu this evening 🧬 🧠

📣📣Registration and call for abstracts now open!
UK Neuromuscular Translational Research Conference 2026
17/18 April, Cambridge, UK
Our 2026 agenda spans acquired/autoimmune and genetic neuromuscular, neurological and neurodevelopmental conditions bit.ly/3XOjZF8

#BrainMeeting 🧠 Alert! 🎺

This Friday, November 28th, the Brain Meeting speaker will be Tricia Seow giving a talk entitled "Biases in belief and simulation in obsession-compulsion"

In person or online. For more information:
www.fil.ion.ucl.ac.uk/event

AI tool spots blood cell abnormalities missed by doctors An AI tool that can analyse abnormalities in the shape and form of blood cells, and with greater accuracy and reliability than human experts, could change the way conditions such as leukaemia are…

An AI tool that can analyse abnormalities in the shape and form of blood cells, and with greater accuracy and reliability than human experts, could change the way conditions such as leukaemia are diagnosed, finds a study co-led by a @uclqsion.bsky.social academic.

“I stopped saying no to things” Joe Gregory on Parkinson’s, football and taking part in research Why is research participation important? We speak to Joe Gregory, England walking footballer and Parkinson’s research advocate, about why he got involved with research at UCL.

👟 Meet Joe Gregory — England walking footballer and Parkinson’s research champion. He’s taken part in a whopping 12 research projects at @uclqsion.bsky.social and other universities to help find better treatments.
Read more:

Interview with Professor Giampietro Schiavo ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...

Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...

Research Assistant: Diagnosis using digital & AI tech Research Assistant at UCL Dementia Research Centre London working with Philip Weston on early Alzheimer changes using digital and AI methods.

Research Assistant at UCL Dementia Research Centre London working with Philip Weston on early Alzheimer changes using digital and AI methods. Closing date: 10th December

www.dementiaresearcher.nihr.ac.uk/job/research...

CANVAS causing AAGGG repeat expansions cause tissue-specific reduction in RFC1 expression and increase sensitivity to DNA damage Biallelic AAGGG expansions in Replication Factor Complex Subunit 1 ( RFC1) are associated with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) and are increasingly recognised as ...

One more pre-print!

www.biorxiv.org/content/10.1...

This is an amazing collaboration investigating the mechanisms underlying an intriguing and mysterious neurodegenerative disorder: cerebellar ataxia and sensory neuropathy caused by AAGGG repeat expansions in the RFC1 locus.

AI tool spots blood cell abnormalities missed by doctors An AI tool that can analyse abnormalities in the shape and form of blood cells, and with greater accuracy and reliability than human experts, could change the way conditions such as leukaemia are diag...

An AI tool that can analyse abnormalities in the shape and form of blood cells, and with greater accuracy and reliability than human experts, could change the way conditions such as leukaemia are diagnosed, finds a study co-led by Prof Parashkev Nachev @uclqsion.bsky.social

Updated global guidelines aim to speed up Multiple Sclerosis diagnosis Updated international guidelines for diagnosing multiple sclerosis (MS), co-authored by UCL academics, aim to improve diagnostic accuracy and reduce delays in treatment initiation.

Experts from @uclqsion.bsky.social are among those who have updated the international guidelines for diagnosing multiple sclerosis. The update aims to improve diagnostic accuracy and reduce delays in treatment initiation to improve long-term outcomes.

Wonderful news and hugely well deserved, Nadine is knocking it out of the park! 👏👏👏

Magrinelli et al. define the pheno-genotypic spectrum of NDUFA9-related mitochondrial disease in 12 cases. Biallelic NDUFA9 variants cause complex I deficiency, with symptoms from neurodevelopmental delay with dystonia to isolated dystonia with basal ganglia MRI abnormalities 👉 buff.ly/t5XWVkv

Micro-/nano-plastics accentuate Parkinson's Disease-relevant phenotypes in a Drosophila model Micro- and nano-plastic (MNP) particles are a ubiquitous environmental contaminant that are increasingly bioaccumulating in human tissues, particularly the brain. MNPs induce mitochondrial defects, ox...

Pre-print alert! Very happy to highlight two fantastic pre-prints on bioRxiv led by stellar post-doc Simon Lowe @satlowe.bsky.social in the lab.

Pre-print no. 1 is a paper I am particularly proud of:

www.biorxiv.org/content/10.1...

Sir John Hardy (@uclqsion.bsky.social) is on Esquire’s Better Men List 2025 for pioneering Alzheimer’s research. We’re proud to see him recognised as a role model in science. 🔗 https://www.ucl.ac.uk/brain-sciences/news/ucls-professor-sir-john-hardy-named-esquires-better-men-list-2025

We’re recruiting an institute director, take a look!

👇🏻

Charcot redux Jean-Martin Charcot was born in Paris on 29 November 1825. To mark the bicentenary of his birth, the International Society for the History of the Neuroscie

To commemorate the bicentenary of Jean-Martin Charcot's life. Without him Neurology would be a different speciality.
@uclqsion.bsky.social @brain1878.bsky.social @masudhusain.bsky.social

academic.oup.com/brain/articl...