Andrew Wood

Great to get together with the original genetics of complex traits team @exeter.ac.uk for the 30th birthday celebration of the genetics lab. We haven’t changed a bit! @rmfreathy.bsky.social @timfrayling.bsky.social @drarwood.bsky.social @mnweedon.bsky.social Hana Lange Allen & John Perry

14.09.2025 14:57 — 👍 9    🔁 3    💬 0    📌 0

Exclusive | Anne Wojcicki Wins Bidding for 23andMe Regeneron is backing away from buying the DNA-testing company after a nonprofit controlled by co-founder Wojcicki made a higher bid.

In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war.

www.wsj.com/tech/biotech...

13.06.2025 21:15 — 👍 3    🔁 2    💬 2    📌 0

Regeneron buys 23andMe
investor.regeneron.com/news-release...

19.05.2025 13:30 — 👍 0    🔁 0    💬 0    📌 0

Enjoyed contributing to the Broad's Medical and Population Genetics seminar series today and hearing some great talks. Thanks @joelhirschhorn.bsky.social for inviting me to speak.

10.04.2025 20:02 — 👍 0    🔁 0    💬 0    📌 0

Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations Genetic association studies have mostly focussed on common variants from genotyping arrays or rare protein-coding variants from exome sequencing. Here, we used whole-genome sequence (WGS) data in 672,...

Really excited to share our next population-scale WGS work preprint. Here, we analyse three anthropometric traits in nearly 700,000 individuals (discovery UKB ~450K, replication AoU). We show, for these traits, that common and rare variant heritability is convergent

www.biorxiv.org/content/10.1...

26.02.2025 16:11 — 👍 14    🔁 8    💬 1    📌 2

Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels Nature Genetics - Rare variant association analysis of plasma proteins using whole-genome sequencing data in 54,306 individuals in the UK Biobank demonstrates that combining both single-variant and...

Excited to finally share that our paper looking at the effect of rare non-coding variants using WGS on circulating protein levels in the UKB has been released in Nature Genetics @naturegenet.bsky.social! We now analyse the full 3,000 circulating proteins in all 50,000 individuals rdcu.be/ea16i

24.02.2025 18:26 — 👍 32    🔁 19    💬 1    📌 2

3/3. Thanks to Xihao Li, Zilin Li, Xihong Lin and others for the great collaboration.

29.01.2025 05:22 — 👍 0    🔁 0    💬 0    📌 0

2/3. We describe the vcf2agds toolkit - a streamlined and reproducible toolkit for processing the WGS data in UK Biobank from VCF to aGDS files for use with the STAAR pipeline that includes a x1336 reduction in total file size. Some of the tools can be used for general processing of the data also.

29.01.2025 05:19 — 👍 1    🔁 0    💬 1    📌 0

Streamlining Large-Scale Genomic Data Management: Insights from the UK Biobank Whole-Genome Sequencing Data Biobank-scale Whole-Genome Sequencing (WGS) studies are increasingly pivotal in unraveling the genetic bases of diverse health outcomes. However, managing and analyzing these datasets' sheer volume an...

Excited to see our paper on medRxiv "Streamlining Large-Scale Genomic Data Management: Insights from the UK Biobank Whole-Genome Sequencing Data". Paper here:
www.medrxiv.org/content/10.1.... Tools here:
github.com/drarwood/vcf....

29.01.2025 05:07 — 👍 2    🔁 1    💬 1    📌 0

I'd forgotten what a good song this is.
www.youtube.com/watch?v=fFhd...

14.01.2025 19:31 — 👍 0    🔁 0    💬 0    📌 0

23andMe have just announced their TRE. See here 👀: investors.23andme.com/news-release...

08.01.2025 20:04 — 👍 0    🔁 0    💬 0    📌 0