Ignacio G. Bravo

« L'image publique d'une science unifiée doit être abandonnée» — TheMetaNews Comment analysez-vous la récente réélection de Donald Trump ? Si l’on s’écarte de la science un instant, l’analyse que je fais en tant que politologue est la suivante : on considère souvent Donald Tru...

Instructive et nuancée, la sociologue Eve Seguin @themeta.news, sur le décisionnisme "à la base duquel se trouve l’idée que la volonté politique prime sur l’ordre constitutionnel". Des parallèles avec l'imposition des "lignes directrices" et #keylabs @cnrs.bsky.social

themeta.news/limage-publi...

Forecasts on death toll in European cities because of increasing temperatures. Anything below parallel 44, and especially the Mediterranean arch, will suffer.
More data won't convince any sceptics, though.

www.nature.com/articles/s41...

Translation of the downstream ORF from bicistronic mRNAs by human cells: Impact of codon usage and splicing in the upstream ORF Biochemistry textbooks describe eukaryotic mRNAs as monocistronic. However, increasing evidence reveals the widespread presence and translation of upstream open reading frames preceding the “main” OR...

Just published! We show that eukaryotic ribosomes can handle bicistronic mRNAs by leaky scanning. Efficiency depends on codon usage and splicing on the upstream ORF. This helps understand non-canonical translation from polycistronic viral mRNAs.
onlinelibrary.wiley.com/doi/10.1002/...

The Population Genetics of Biological Noise Noise is intrinsic to information transmission, and information transmission is intrinsic to life. Critically, while biological noise is random, its amount is in part genetically determined. Here, we ...

On the importance of being (biologically) faithful. We show in this preprint that there exists an equilibrium in the #noise and fidelity levels in information transfer in biology, that depends on the environment, #populationsize and #genotypetophenotype mapping.

www.biorxiv.org/content/10.1...

Can a biologist fix a radio?—Or, what I learned while studying apoptosis As a freshly minted Assistant Professor, I feared that everything in my field would be discovered before I even had a chance to set up my laboratory. Indeed, the field of apoptosis, which I had recent...

"Can a biologist fix a radio?" A (to me) hidden gem that reminds me that some of my conceptual and experimental approaches in biochemistry, mol bio and cell bio may hamper rather than help for understanding life.

www.cell.com/cancer-cell/...

Post en français. Le nouveau ministre chargé de l’Enseignement supérieur et de la Recherche, Philippe BAPTISTE, se réclame chercheur et fait sa déclaration d'intentions. La musique est bonne. On attend les paroles. Merci @themeta.news pour le texte complet.
themeta.news/wp-content/u...

Las matemáticas que explican por qué retirarse a tiempo es una victoria John Maynard Smith revolucionó el estudio de la evolución y del comportamiento animal aplicando la teoría de juegos a los sistemas dinámicos. Sus ideas se usan en múltiples problemas en economía, filo...

Post en español. Entretenida (y hermosa!) divulgación de la #teoríadejuegos aplicada a la #evolución por Alejandro Couce.
elpais.com/ciencia/cafe...

(3/3) Check out details here pallareslab.github.io/bionoise2025... - We have only 40 spots, so register soon! @smbmathbiology.bsky.social

(2/3) Come to Tübingen to discuss this with us! We are hosting an SMBE Satellite Meeting on the 'Origin, Maintenance, and Evolution of Biological Noise' in June 2025. Co-organizers: Julien Dutheil, Nacho Bravo, and Dan Weinreich.

(1/3) Ever wonder if there is anything in common between people studying #plasticity, #variability, #robustness, #bethedging, #variance, error-prone #molecularmechanisms? Might we all be thinking about different manifestations of Biological Noise? @official-smbe.bsky.social @mpi-bio-fml.bsky.social

Hello, Bluesky world

happy to join the community and discuss about the evolution of viruses, infections and cancer, information transfer in biology, and about the Russian-doll structure of life, from molecules to cells to tissues, to individuals, to communities.

Cheers!