@marcussaemann.bsky.social
Nephrology - Internal Medicine, Diabetes survivor, Tennis - R. Federer, T. Mann, J. Haydn Afficionado @oegnephro MARKUS@HOMe
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
GLP1ra in ADPKD?
pubmed.ncbi.nlm.nih.gov/40815122/
It's Congress-Update time!
Check out our new webinar "Post ESC 2025"!
youtu.be/6C6lJWUHlc8?...
For nuance: while leucine is framed as proinflammatory by augmenting atherosclerosis in mice via macrophages supposedly via mTOR, mTOR activation is actually the most prominent anti-inflammatory signaling mediator in myeloid cells such as macrophages (also via AA). Yes nature is complicated…
31.08.2025 20:45 — 👍 4 🔁 0 💬 0 📌 0Eagerly waiting!
31.08.2025 11:23 — 👍 1 🔁 0 💬 1 📌 0
New in #ASNJASN: Remote volume monitoring in heart failure has big potential. Implantable hemodynamic sensors offer early, actionable data vital for patients with kidney diseases. kidney.pub/JASN0843
Kidney function trajectories before and after hospitalization for HFrEF by Drs. Kobayashi, Girerd et al.
academic.oup.com/eurheartj/ar...
In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.
Today at #WTC2025:
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp
@ttsorg.bsky.social
Personal experience: no issues at all incl. Tac levels, side effects similar to the non-Tx population
04.08.2025 15:11 — 👍 2 🔁 1 💬 2 📌 0One big outcome is the change in GFR slope. Tirzepatide slowed GFR decline by 3.54ml/min at 36 months which is absolutely fantastic! I imagine this has something to do with the reduction in mortality given how much mortality is caused by kidney disease in diabetics.
31.07.2025 12:57 — 👍 3 🔁 1 💬 1 📌 0
SURPASS CVOT #T2D #Tirzepatide Non inferior but numerically superior for some endpoints #CVD investor.lilly.com/news-release...
31.07.2025 11:21 — 👍 7 🔁 3 💬 0 📌 1
Auch wenns wehtut, @harrybergmann.bsky.social lesen:
www.falter.at/loge17/20250...
Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews
@nephrosparks.bsky.social
SGLT2i in CKD: impact beyond kidneys
🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years
Large absolute gains for patients & health systems
Meta-analysis in @asnpublications.bsky.social
journals.lww.com/cjasn/pages/...
Mechanistic target of rapamycin (mTOR) inhibitor–based immunosuppression was associated with an improved T-cell response to vaccination in kidney transplant recipients. Read more in #ASNJASN: kidney.pub/JASN0716
@chengshengchai.bsky.social @griffithperkins.bsky.social
Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study
bit.ly/Liyanarachi2... #OpenAccess
#VisualAbstract
A bold guideline from the beginning!
“We suggest that all individuals with hypertension be screened for primary aldosteronism”
A figure showing the changes from baseline in systolic blood pressure (SBP), plasma aldosterone–renin ratio (ARR), and serum potassium level for each patient.
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz
#ENDO2025
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
This is new. Higher vitamin D levels associated with higher prostate cancer prevalence 🤦🏻♂️
I'm sure the "taking vitamin D couldn't hurt" crowd will have an explanation forthcoming
Using an MRA empiricially or renin-guided therapy in apparent treatment resistant hypertension?
academic.oup.com/ajh/article/...
#WeekendReads from the #EditorsChoice archives
The 62nd ERA congress Allstars: Late-breaking studies 2025
Our guests:
@lonniepyne.bsky.social
@lastwalsh.bsky.social
Vianda Stel
Fadi Fakhouri
Hans Mann
Natalie Staplin
Jonathan Barratt
@rosertorra.bsky.social
@katestevens.bsky.social
youtu.be/HbUEh8oLB2M?...
Best of ERA 25 @markusathome.bsky.social with
@lonniepyne.bsky.social @lastwalsh.bsky.social
Dr. Stel Dr. Staplin Dr. Mann Dr. Fakhouri
@rosertorra.bsky.social @katestevens.bsky.social @marcussaemann.bsky.social @sarahelena.bsky.social
@dgfn.bsky.social @sfndt.bsky.social
youtu.be/HbUEh8oLB2M?...
youtu.be/s-iglqVIp2s?...
With @marcussaemann.bsky.social @sarahelena.bsky.social @rosertorra.bsky.social Prof. Anders Prof. Stevens
"The perfect storm to support the darkest forces. ...If we don’t engage this crisis with the courage of those who fought on this continent in WW2, then I sense we risk the eventual ramp up to carnage that could easily surpass that."
Speech to legislators yesterday.
www.linkedin.com/pulse/addres...
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan www.kireports.org/ar...
09.05.2025 06:00 — 👍 9 🔁 6 💬 0 📌 1
Kidney disease should be recognised on WHO's priority list of non-communicable diseases, alongside cancer, cardiovascular disease, and diabetes
https://go.nature.com/4lLJ5iY
Fascism is now in the algorithms, the neural pathways, the social interactions. How did we fail to see all this? “We wanted to see Trump in terms of his absences, so that our way of seeing the world would go unchallenged,” Timothy Snyder writes.
19.04.2025 20:47 — 👍 1121 🔁 465 💬 667 📌 441sodium 129, patient asymptomatic. please advise
19.04.2025 09:04 — 👍 3 🔁 1 💬 0 📌 0
For patients with lupus nephritis, a recent phase 2 trial showed that the addition of obinutuzumab to standard therapy was associated with a significantly better renal response than placebo. Findings of the REGENCY phase 3 trial are summarized in a new Quick Take video. youtu.be/cqu42EDvPq8
#MedSky
