FlexNP

Use of GLP-1 Drugs Under Scrutiny at Winter Olympics Anti-doping group includes novel diabetes, weight-loss drugs in its monitoring program

I've been predicting this would happen. I suspect they'll get banned in certain sports where weight matters, biking, rowing, etc.

Even more so when glucagon agonists come around(that requires more than 300 letters to explain)

lmao even

Talk about covering yourself in gasoline then thinking you can be next to an open flame without consequences. Absolutely finding out phase.

Oh so glad you're doing ok. The radio silence had me worried! Feel better!

The market forces will be incredibly dynamic this year. Between generic semaglutide, multiple new drugs are launching in the next year, orforglipron vs oral Wegovy will be a battle as well. Hopefully patients see improved cost and access

That's the 3rd GLP1 ad

(Also I appreciate that commercial not being a bunch of white people! Minorities in the USA have high rates of obesity too!)

Needed to follow that up with a Wegovy pill commercial

It'll take me all game to drink it 😂

Superb Owl beverage. Coconut rum barrel aged stout. SO. DAMN. GREAT.

We bought weather tech for my wife's Ford Explorer. I believe it was like $700 for the full car. They're durable as hell but also the price is eye watering so I'm less surprised

Dude. She looks amazing. Tirzepatide is 👑

Which is why compounding and such is still so widespread. Definitely need to continue to increase access/lower cost

I'd be here for that in a big way.

GLP1 commercial count for the Super Bowl: 1

As long as they insult JD Vance in one of their songs I'll be satisfied

Think it'll be more important for Reta than tirzepatide since the lipid reductions, BP and kidney GFR improvements look to be dose dependent for that drug in particular

Yup. Tho some ongoing research with tirzepatide(topline later this year) on maintenance dose. Either max tolerated dose or reduced to 5mg after maximum weight loss.

Same trial design also running for retatrutide but that won't finish until 2028 so we'll get some answers from an RCT on it

The textures from the wind were so so cool!

The ice is over a foot thick on the river. It was a bright and sunny morning. So I did some exploring, almost to the Canadian border on the frozen river. Magnificent ice and snow formations!!

I think the longer these meds are out the more true this will be. The benefits are too great. Surmount MMO will give us a really good look at long term benefits as they're looking at morbidity and mortality reductions from literally every angle.

That'll be shorts and T-shirt weather here in Michigan no joke.

Oof. Tamiflu?! It's safe in pregnancy, wife unfortunately had the same thing happen to her with our second. Feel better!!

Molecular Design of Unimolecular Tetra-receptor Agonists Peptide hormone-receptor interactions serve as critical regulators of metabolic homeostasis, a paradigm exemplified by the clinical efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists. Building upon this framework, strategic design has ...

Very awesome!! I've heard it's a bit like trying to solve a Rubik's cube esp in terms of shape, binding affinity to the target etc. This article talks about what I mean. Mess with literally one amino acid and the whole thing falls apart.

Thank you for your contributions 🙂

Which drug if you don't mind me asking?

Just another balmy day by the water 😂

Running long distances for no apparent reason. Yeah. That's me. Even my wife makes fun of me when I finish a race or long run and can't walk for two days 😂

Seeds! There might be snow on the ground but it's time to start tomatoes, peppers, leeks and cabbage indoors!

9.3 miles of running this morning. Goal was 11-12 miles. Except the windchill was -10F and my water bottle froze nearly solid at mile 8 and I couldn't feel my toes so I suppose that was the sign I should stop a little early today. 🤷

Training for ultra marathons, not for the faint of heart 😂

Welllll it's also winter time 🤷😂