FlexNP

McConaughey is so great in Contact tho! One of his earliest roles.

Truly one of his better roles until he starred in another space movie.

Don't worry you're not alone in that part as the dad of 2 daughters

Interstellar, The Martian and Contact.

All absolutely 💯 space flicks. So much goodness in all of them.

One of my all time favorites. Watch at least once a year.

Crispy air fried wings + chiltepin pepper + teriyaki, toss the wings in the combined sauce for spicy & sweet deliciousness

As an actual autistic human being this shit is just obnoxious at this point. Most people are surprised to find out I'm autistic because I learned to mask, learned to cope with my sensory issues and went to fucking therapy. I still stumble occasionally with social cues.

Your drug abuse is not autism

Same! Also love the trial design. Everyone gets the drug for 80 weeks. That's a good way to goose numbers and retain people in the trial

They're honestly not that hard! A blender, cast iron pan, eggs, milk, flour, sugar, salt. Season with whatever spices you want. Can be savory or sweet!

@grandvillain.substack.com Dutch baby this morning with cinnamon and cloves to the batter then light dusting of powdered sugar to eat it with

Eventual maintenance doses. Damn autocorrect. It's 80 weeks open label of the drug for everyone, no placebo at first. Then 1/3 get placebo, 1/3 get maintenance dose 1/3 continue max tolerated dose for another 36 weeks.

My cousin is in Triumph-6 it's a retatrutide trial exploring event maintenance doses. His first dose was June 30th of this year.

He's now on the 12mg dose for the last 2 months. He's lost 81 pounds. 24.9% of his starting weight in 160 days!!! Minimal side effects. Insane drug.

Penzeys and Badia are my goto spice mongers. Always good stuff from both. Have you tried making traditional birria or carnitas yet? Also so damn good/worth the effort.

Eloralintide. You'll be hearing a lot more about it in the next year. Selective Amylin agonist with almost zero calcitonin activity. 16-20% weight loss with plateau at 48 weeks. 3/6/9mg comparable side effects to 5mg of tirzepatide (aka VERY tolerable/minimal side effects)

I've got an absolute banger of a butter chicken recipe myself. It's fun to make, makes a boatload of food and really isn't that hard once you get past the spice list!!

a man is cooking food in a kitchen with a wok . ALT: a man is cooking food in a kitchen with a wok .

Dusty May let that man cook and whew 🔥🔥

Lays needs to make these permanently. Absolute 🔥🔥 flavor. Just spicy enough, lots of garlic and a slight sweet note.

Fun fact, the 1mg group had LESS side effects than placebo, lost on average 10% of their body weight and 50% of the patients dropped out of that arm citing lack of efficacy. We've primed people so much to expect side effects that when they don't happen, they think they're on placebo!! Crazy stuff

Eloralintide. You'll be hearing a lot more about it in the next year. Selective Amylin agonist with almost zero calcitonin activity. 16-20% weight loss with plateau at 48 weeks. 3/6/9mg comparable side effects to 5mg of tirzepatide (aka VERY tolerable/minimal side effects)

Going next weekend and will be seeking this out

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Had a MyChart message from our Medical Director of Transplant thanking me for "my excellent collaboration of care" in taking care of a recent transplant patient 😳🙂

Bacon on grilled cheese is undefeated.

Come on man. You only have yourself to blame.

Also the reduction in thyroid meds are interesting. All that extra lipolysis probably helps along with less body mass in general. Interesting stuff. We'll see what the data shows in about 5 months

@proptermalone.bsky.social @mikejohansenmd.medsky.social @hswapnil.medsky.social

But from my own personal trial experience my LDL cholesterol dropped ~57%(163mg/dl ---> 71mg/dl so yeah I can see reducing a statin dose if Reta pushed their LDL to like the 20-30mg/dl range.

Also don't yell at me for saying that 🤣 I know statins are gold standard

This trial recruited folks with existing cardiovascular disease and a BMI>35, IE morbid obesity. This person had an outcome that 1.) exceeded bariatric surgery 2.) stopped all BP meds and 3.) reduced their statin + thyroid med

That's 🤨🤨 especially the statin part.

I don't think we're fully prepared for the retatrutide trial data. Here's a participant from Triumph 3 which is the shorter CVOT trial they ran

"I just finished TRIUMPH 3 (cut short from 104 wks to 88 wks). Lost 37% of body weight, off all BP meds, and reduced cholesterol and thyroid meds"

From my clinic it was pretty awesome too.

Not sure who will grab them. Molecule is very well tolerated and I'm sure the 48 week trial will show fibrosis improvement. Not sure Pfizer would grab them. Maybe a company without a presence in the market. Abbie, Bristol Myers? Not sure.

And this trial didn't even test the highest dose (2.4mg)

We use Charmin usually, hopefully that's an acceptable answer 🤣

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Me prescribing Telmisartan and Tirzepatide together knowing their hidden synergy: