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Josh Leisring

@joshleisring.bsky.social

Nephrologist / Hypertension Specialist in Columbus, Ohio #Nephsky He / him

233 Followers  |  118 Following  |  93 Posts  |  Joined: 02.02.2025
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Posts by Josh Leisring (@joshleisring.bsky.social)

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What high blood pressure does to your body Hypertension can affect your mind, heart, eyes and more, often without causing any obvious symptoms at all.

Excellent overview in The Washington Post on the systemic impact of sustained hypertension β€” from LVH to CKD and cognitive decline.

Kudos to Drs. @drwanpen.bsky.social , John B, and @jordybc.bsky.social for evidence base insight.

πŸ”— www.washingtonpost.com/wellness/202...

#Hypertension #Cardiology

28.02.2026 20:52 β€” πŸ‘ 6    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Think I just had a pt with olmesartan enteropathy

Yall seeing this? I’ve mostly moved away to tel, irb but have a fair number of legacy pts

#medsky #cardiosky #nephsky

26.02.2026 19:46 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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🧠 Dr. Vaidya’s @anandvaidya17.bsky.social
practical approach to primary aldo, distilled into one clean, clinic-ready infographic:

This is high-yield, no-fluff, practice-changing stuff.

26.02.2026 18:06 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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New! πŸŽ™οΈπŸ©ΊπŸŽ§ #515 Primary Aldosteronism, A Deep Dive: Easy on the Salt! πŸ§‚β¬‡οΈ

Hypertension is everywhere and primary aldosteronism is a common (and often missed πŸ‘€) cause. Join us with @anandvaidya17.bsky.social of Brigham and Women’s Hospital

23.02.2026 12:49 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1

www.youtube.com/watch?v=mqpl...

23.02.2026 19:58 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
UKKA BP in dialysis visual abstract

UKKA BP in dialysis visual abstract

Very practical UK Kidney Association guidelines for management of BP in Dialysis
www.kireports.org/article/S246...
KI Reports

19.02.2026 03:12 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
figure 1

figure 1

sweet

A @asnpublications.bsky.social perspective argues we need a Spironolactone versus nsMRA head:head trial!

journals.lww.com/jasn/pages/a...

Bring it on!

#NephSky #SpiroStans rejoice

13.02.2026 14:34 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1
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Smartwatch and Hypertension Notification This cross-sectional study assesses the potential impact of a smartwatch hypertension notification feature for US adults who have not been diagnosed with hypertension.

Excited to share our research letter published today in JAMA on the new Apple Watch Hypertension Notification Feature! jamanetwork.com/journals/jam...

1/n

09.02.2026 17:21 β€” πŸ‘ 13    πŸ” 8    πŸ’¬ 1    πŸ“Œ 2

Thank you @asnpublications.bsky.social for posting our paper on the transformation of venous to arterial blood gas. To facilitate calculations, I developed an App β€œVenous to Arterial Blood Gas” available for free (apps.apple.com/us/app/venou...)
@nu-nephrology.bsky.social @feinberg.northwestern.edu

09.02.2026 20:35 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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For example, my institution's lab historically reported renin/aldo with these reference ranges. Cases of overt PA could be interpreted as normal. But results are now reported with guidance on interpretation with the relevant cutoffs from our lab's assays.

23.01.2026 13:30 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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I think there could be more clarity in how many labs report results. i.e what threshold should be considered a suppressed renin, positive screen, etc. The variety of different assays/units remains a major source of confusion. Most clinicians won't be aware of Table 5 from the Endo society guideline

23.01.2026 13:22 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0

I'm in favor of doing the initial screen in non-optimal setting. Remove barriers to testing. The most overt cases will still be identified. In borderline cases if clinical suspicion is still high, can repeat under more standardized conditions (including considering medication effects).

23.01.2026 13:13 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
https://www.endocrine.org/clinical-practice-guidelines/primary-aldosteronism-2

https://www.endocrine.org/clinical-practice-guidelines/primary-aldosteronism-2

As guidelines rec more Aldo/renin testing in htn, wondering whats labs role to ensure/capture details on relevant factors (timing, Na restriction, meds, KP)? Should labs rec pts test in more standardized conditions, log key details or just do it-clinicians duty to sort out? @askrenal.bsky.social

22.01.2026 13:37 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0
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Apple Watch for Hypertension Screening | Hypertension

Excited to share our thoughts on the Apple Watch Hypertension alert!
@jordybc.bsky.social @deanpicone.bsky.social @alta-schutte.bsky.social

Apple Watch for Hypertension Screening | Hypertension www.ahajournals.org/doi/10.1161/...

21.01.2026 21:24 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Cuffless blood pressure in 2025: from promise to practice: a narrative review - PubMed Cuffless wearables may be used as adjuncts to surface patterns and support engagement; diagnosis and treatment decisions must be confirmed with validated upper-arm measurements. A pragmatic "good-enough" checklist includes stable calibration over weeks, accuracy across dynamic states and subgroups, …

Cuffless BP review with @farahwehbe92.bsky.social - incoming HT fellow in Ottawa, with tables, and details of technology, devices and ongoing trials

pubmed.ncbi.nlm.nih.gov/41460057/

thanks to @profdg.bsky.social for the invite!

07.01.2026 23:13 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
American Heart Association Journals

Dan Batlle & I wrote about testing for primary aldosteronism, bringing a critical lens to the usual approach

www.ahajournals.org/doi/full/10....

22.12.2025 18:14 β€” πŸ‘ 12    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

We have so much evidence demonstrating the real clinical impact of renin (predicting response to MRAs in PATHWAY-2, increased CV risk when renin remains suppressed, etc). I would hope AngII testing could be incorporated into trials to build a dataset for comparison.

23.12.2025 02:16 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Thought-provoking read! I wonder if this should be a more common measurement in clinical trials (nsMRAs, ASIs, etc) since the studies so far have involved small numbers of patients. Without more concrete data showing the clinical utility it is hard to justify muddying the waters more.

23.12.2025 02:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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🚨 Fresh Hypertension Guidelines Alert 🚨

Don’t get caught treating high blood pressure like it’s 2024 πŸ‘€

In Episode #509, West Philly doc Dr. Jordy Cohen @jordybc.bsky.social
keeps our hypertension management fresh with a clear walk-through of the new HTN guidelines & more!

www.thecurbsiders.com

22.12.2025 19:10 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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AHA Scientific Statement on Single-Pill Combination Therapy
www.ahajournals.org/doi/10.1161/... #Nephsky

16.12.2025 14:18 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Clinical Hypertension Fellowship

If you are interested in hypertension training and research, check out our hypertension fellowship.

research.bidmc.org/medicine-gme...

12.12.2025 21:19 β€” πŸ‘ 1    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Happy to contribute to this important statement
@ahascience.bsky.social on cuffless devices led by @jordybc.bsky.social !

Cuffless Devices for the Measurement of Blood Pressure: A Scientific Statement From the American Heart Association | Hypertension ahajournals.org/doi/10.1161/...

11.12.2025 13:36 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Impact of Age, Sex, and Race on Primary Aldosteronism Test Interpretations | Hypertension BACKGROUND: New guidelines recommend testing for primary aldosteronism (PA) in all people with hypertension. Interpreting population-based results for PA will require understanding the influence of de...

"Older and Black participants had higher aldo-to-renin ratio...and women had higher aldo levels than men across the lifespan. With newly expanded indications for PA testing, a greater appreciation of the influence of demographic characteristics will be required." #nephsky
tinyurl.com/yc8ryxmu

11.12.2025 13:17 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
VA of SPARK trial

VA of SPARK trial

Our take on the baxdrostat PA trial in @asnpublications.bsky.social #KidneyNews

www.kidneynews.org/view/journal... with @nephroseeker.medsky.social and @dramiliflores.bsky.social !

Thanks to Sam Kant and @kdjhaveri.bsky.social for the invite!!

09.12.2025 02:33 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1
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NephJC Shorts: Hypertension and The Extreme Elderly β€” NephJC The NephJC shorts version of the Hypertension medication step-down in a nursing home population from NEJM

πŸ†• #NephJCshort by @brianrifkin.bsky.social

RETREAT-FRAIL- pragmatic RCT: is less BP medication worse in octogenarians?

www.nephjc.com/news/hyperte...

04.12.2025 09:12 β€” πŸ‘ 13    πŸ” 7    πŸ’¬ 2    πŸ“Œ 1

My first month of trying to prescribe fish oil at the dialysis unit has been a total failure

Pharmacies arn’t filling scripts and patients can’t find OTC matches to dose prescribed in PISCES

Anyone having success on the high seas?

02.12.2025 19:21 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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To Treat or Not to Treat? Watchful Waiting or Oral Antihypertensives for Asymptomatic Inpatient Hypertension | NEJM This feature about a man hospitalized for uncomplicated diverticulitis who is found to have high blood pressure offers a case vignette accompanied by two essays, one supporting ...

To Treat or Not to Treat? Watchful Waiting or Oral Antihypertensives for Asymptomatic Inpatient Hypertension
#nephsky #nephrology
www.nejm.org/doi/full/10....

20.11.2025 11:02 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Hypertension Fellowship

Ahead of #KidneyWk25, we are recruiting a hypertension fellow to the Stanford Hypertension Center for July 2026. Please come find me at ASN.

med.stanford.edu/nephrology/e...

05.11.2025 07:57 β€” πŸ‘ 6    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Samir Parikh gives an update on lupus nephritis. #KidneyWk Looking for rapid reduction of proteinuria? Voclosporin is faster, but belimumab showed similar separation from placebo, it just takes longer due to mechanism of action.

05.11.2025 15:38 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0
A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.

A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.

BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ

15.10.2025 19:02 β€” πŸ‘ 12    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1