Birmingham Liver

Huge congratulations to Prof. Ye Htun Oo!

Successful Wellcome Trust Discovery Award: Stopping the Clock on Chronic Inflammation.

#clgr #wellcometrust #yehtunoo

"Absolutely phenomenal news! This is an amazing achievement, supporting a programme of work for the next 8 years" - Prof. Shishir Shetty

#bioinformatics #liverdisease #scrnaseq #ai #masld | Deena Mohamad Gendoo It was an absolute pleasure to help develop our Bioinformatics in Hepatology workshop at Birmingham! An exciting day and packed agenda exploring #bioinformatics research in #liverdisease! We've also g...

#clgr #bioinformatics #liverdisease #scrnaseq #ai #masld
Bioinformatics and Transcriptomics in Hepatology Workshop - 11th September
www.linkedin.com/posts/deena-...

#in2science #birminghambrc | Patricia Lalor Just finished a great week working with local students interested in STEM careers. Opportunity to showcase the great translational research infrastructure and diverse career roles here in Birmingham. ...

www.linkedin.com/posts/patric...
#clgr #stem #in2science #birminghambrc

Two weeks ago, we hosted a group of sixth-form students from disadvantaged backgrounds for a week-long immersive experience as part of the national In2scienceUK initiative. | NIHR Birmingham Biomedica... Two weeks ago, we hosted a group of sixth-form students from disadvantaged backgrounds for a week-long immersive experience as part of the national In2scienceUK initiative. From hands-on histology wi...

www.linkedin.com/posts/nihr-b...
#clgr #nihrbrcbirmingham #in2scienceuk

Congratulations and very well done to PIs Shishir Shetty, Patricia Lalor, Ye Htun Oo, Chris Weston, Zania Stamataki, and their teams at the CLGR, for obtaining Green Impact Lab Accreditation and the Green Impact Gold Award for Sustainability 😀
#GILA #greenimpactlabaccreditation #sustainability #CLGR

www.birminghambrc.nihr.ac.uk/public-event...

#NIHRBirminghamBRC #liverresearch
#BRC #PPIE #publicengagement

Fantastic news: We’re one of 12 leading British universities and research organisations selected to deliver the UK Government’s £54 million fund to recruit the world’s top researchers. | University of... Fantastic news: We’re one of 12 leading British universities and research organisations selected to deliver the UK Government’s £54 million fund to recruit the world’s top researchers. The University...

www.linkedin.com/posts/univer...
#GlobalTalent #UniversityofBirmingham #InternationalResearch

Stereotactic ablative radiotherapy for patients with hepatocellular carcinoma: analysis of post-treatment radiology and explant histology BJC Reports - Stereotactic ablative radiotherapy for patients with hepatocellular carcinoma: analysis of post-treatment radiology and explant histology

My first post on bsky!

Really pleased to share our paper published today - comparing radiology vs. explant histology following bridging SABR for HCC. A small cohort but highlights the need for radiological criteria to more accurately reflect SABR treatment response in HCC 👉
rdcu.be/emMg2

Congratulations Harriet Hill for defending your PhD thesis! | Zania Stamataki Congratulations Harriet Hill for defending your PhD thesis! 🎓🥳 As a technician PhD student funded by the Medical Research Foundation starting at the pandemic, you were one of our busiest and most pro...

Congratulations, Harriet! 🎉
#harriethill #clgr #liverresearch

www.linkedin.com/posts/zania-...

🎓 Officially Dr. | Amber Bozward 🎓 Officially Dr. Amber Bozward! After years of research, learning, challenges, and breakthroughs, I’m proud to have completed my PhD in Immunology at the University of Birmingham. My work focused on...

Congratulations Amber! 🎉
#amberbozward #clgr #liverresearch

www.linkedin.com/posts/amber-...

Photo of Professor Palak Trivedi with a big grin.

Congratulations! 😀

Palak Trivedi has just become Professor of Cholestatic Immune-mediated Liver Disease.

This recognises his impact in the field of cholestatic liver disease and the liver-gut axis and his contribution to developing new therapies for patients with immune- mediated liver disease.

Centre for Liver and Gastrointestinal Research - University of Birmingham Delivering basic science research into human liver disease.

The CLGR website has had a long overdue update recently.

#clgrwebsite #clgr #liverresearch

www.birmingham.ac.uk/research/cen...

Today's festival at the University of Birmingham Green Heart was a truly community-focussed event. Tasty food, nice weather, plenty of stalls showcasing very interesting research, and lots of activities to keep the youngsters happy and engaged 😊.

#cometocampuscommunityfestival #clgr #liverrresearch

University of Birmingham invites the city to 125th anniversary celebration - University of Birmingham The University of Birmingham is hosting a free Come to Campus community festival this June, to celebrate its 125th birthday.

UoB Come to Campus Festival

#125thanniversarycelebration
#cometocampusfestival

www.birmingham.ac.uk/news/2025/un...

Excellent start to #BSIMidlands2025 with a brilliant summary of the history of Midlands Clinical immunology by Dr Aarnoud Huissoon and important considerations for diagnostic tests by Prof Alex Richter. @bsi-midlands.bsky.social

Get Involved Information about the many ways staff and students can get involved in University sustainability activities and share good practice and ideas and to help shape future initiatives.

#sustainability #greenimpact #getinvolved #uobsustainability

www.birmingham.ac.uk/university/s...

Inflammatory liver disease - NIHR Birmingham Biomedical Research Centre Transforming outcomes for patients with inflammatory liver disease through early diagnosis and developing new therapies.

#birminghambrc #liverdisease #clgr #inflammatoryliverdisease #nihrbrc

www.birminghambrc.nihr.ac.uk/our-research...

Liver Transplant - Online Course Learn about the science behind having a liver transplant with this free online course from the Centre for Liver Research.

#livertransplant

www.futurelearn.com/courses/live...

Liver Disease: Looking after Your Liver - Online Course Learn about how your liver works, ways to look after it and how liver damage is caused, studied and treated around the world.

www.futurelearn.com/courses/live...

Multi-zonal liver organoids from human pluripotent stem cells - Nature Liver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for transplantation in animal models of liver dysfunction.

Nature research paper: Multi-zonal liver organoids from human pluripotent stem cells

https://go.nature.com/3G7Pepk

Burden of Metabolic Dysfunction–Associated Steatotic Liver Disease, 2020 to 2050 This decision analytical modeling study estimates the burden of metabolic dysfunction–associated steatotic liver disease among US adults from 2020 to 2050.

Estimated burden of #MASLD and #MASH over the next 30 years.😮

Future is grim if we don't take active approach from all disciplines and angles, including policy change.

jamanetwork.com/journals/jam...

Head‐to‐Head Comparison Between Phosphatidylethanol Versus Indirect Alcohol Biomarkers for Diagnosis of MetALD Versus MASLD: A Prospective Study Using a well-phenotyped prospective cohort with systematic assessment through MRI-PDFF, MRE, and PEth testing, this study demonstrates that PEth is an accurate, quantitative, objective alcohol biomar...

💡PEth gets another win!

Compared to previously used non-invasive tests in differentiating MetALD from MASLD

#liversky

onlinelibrary.wiley.com/doi/abs/10.1...

£10m funding for new programme to help identify individual cancer risk - Cancer Research UK - Cancer News Today, Cancer Research UK, the NIHR and the EPSRC are announcing £10 million to create the Cancer Data-Driven Detection programme

Together with the NIHR (National Institute for Health and Care Research), the EPSRC, Health Data Research UK (HDR UK) and ADR UK (Administrative Data Research UK), we’re announcing a £10m programme which will help identify individual cancer risk 🙌

Read more 👉 cruk.ink/42q0aaY

Precision models in hepatocellular carcinoma - Nature Reviews Gastroenterology & Hepatology In this Review, Lujambio and colleagues provide an overview of the use of in vitro and in vivo precision models for hepatocellular carcinoma, their strengths and limitations, and how they can be used ...

Current in vitro and in vivo models recapitulate some but not all of the 'HCC influencers', factors that contribute to HCC inter-patient heterogeneity.

Find out more in this REVIEW about precision models for #hepatocellularcarcinoma
www.nature.com/articles/s41...

#Oncsky #Liversky #livercancer

2025 is the perfect year to take your career to the next level🚀

There are also 6 positions to fill in the EASL Scientific Committee, Policy Public Health and Advocacy Committee, Ethics and Compliance Committee and Nurses & AHPs Task Force.

Apply by 20 January: easl.eu/leadership25

#LiverSky

Liver and pancreas in metabolic disease: from pathways to therapies The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD

meetings.embo.org/event/25-liver-pancreas

Metabolic and alcohol-associated liver disease (MetALD): a representation of duality - npj Gut and Liver npj Gut and Liver - Metabolic and alcohol-associated liver disease (MetALD): a representation of duality

So much talk about #MASLD but let's not forget to screen our patients for alcohol consumption as well.

Alcohol + metabolic risk factors synergistically ⬆️steatohepatitis, fibrosis, and hepatocellular carcinoma in #MetALD

nature.com/articles/s44...

New from Ulrike Protzer and team, hepatocyte infection of SARS-CoV-2 and associated cytopathology and tissue damage #LiverSky #ViroSky #Immunosky

Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial - Nature Medicine Results from the phase 2 MATCH01 clinical trial of autologous monocyte-derived macrophage therapy for liver cirrhosis revealed no liver-related severe adverse events or deaths in the treatment group.

Wow after CAR-T cell therapies here come autologous monocyte derived macrophage infusion therapies. The treatment of end stage cirrhosis is liver transplantation, so alternative treatments to salvage the liver are needed.🧪
www.nature.com/articles/s41...

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP
www.science.org/doi/10.1126/...