Kelly McClymont

So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky

📸 frozen section, tumor capsule
📸 frozen section, epithelial cells (ducts) and myoepithelial cells
📸 frozen section, nests of myoepithelial cells in myxochondroid matrix

Dx: pleomorphic adenoma

#Pathsky

6) Immunohistochemistry: PCT is positive in 77% of FLC, but absent in other primary or secondary liver tumors.

In conclusion
👉 serum and tumor PCT = sensitive & specific biomarker for fibrolamellar hepatocellular carcinoma.

Serum Procalcitonin: A Novel Tumor Biomarker for Diagnosis and Follow-Up in Fibrolamellar Hepatocellular Carcinoma Introduction: Fibrolamellar carcinoma (FLC) is a rare primary liver cancer that predominantly affects young patients with normal known serum tumor biomarkers (alpha-fetoprotein (AFP) and CA19-9). An o...

1) We recently identified as serum tumor biomarker of fibrolamellar carcinoma, procalcitonin, with @zucmanrossi.bsky.social and @markyarchoan.bsky.social that you can find in www.medrxiv.org/content/10.1...

YouTube video by Sanjay Mukhopadhyay Pathology of mesothelioma (featuring biphasic mesothelioma and talc pleurodesis)

KikoXP + WSI + videoconferencing + 3 subspecialty experts = new way to educate

#pathsky

youtu.be/LVXlir8s8ik?...

Arteriole with features of a old recanalized thombus in a transplant kidney biopsy. Multiple slit like vascular spaces within the fibrotic lumen. Not a lesion I see often. Pt had clinically diagnosed TMA a few months prior. #renalpath #pathsky #nephsky

‎LiverRisk Score ‎This Liver Risk Score should not be used by the general public. To use this instrument, prior knowledge in biomedicine is necessary. The Liver Risk Score is an easy and simple to use calculator aimed...

🚀Launching the #LiverRiskScore app!
📱A simple digital tool to spot liver disease risk early using routine clinical data!
🔗iOS: apps.apple.com/us/app/liver...
🔗Android play.google.com/store/apps/d...
@ihieurope.bsky.social @easlnews.bsky.social

Eosinophil rich cellular rejection is often associated with vascular rejection. One of the most eosinophilic txp biopsies I've seen. ACR III (v3 lesion). Undetectable CNI level at admission. #renalpath #nephsky #pathsky

Buena.

New platform, same mission.
The CAP is now on Bluesky—join us as we share updates that matter to pathologists and the future of medicine. #pathology #Pathsky

Phaedra ftw

Research

What most people think of how a kidneybworks and how the business of nephrology works.
Dr. Gaddy (living kidney donor)
#RPA25 @renalphysicians.bsky.social #organdonation #nephsky

Interested in learning more about the art of microscopic examination of the urinary sediment and its clinical applications? @jrseltzer.bsky.social @swethakanduri.bsky.social and I will be running a Hands-On Workshop at KidneyCon this year. Come join us! @kidneycon.bsky.social May 1-3. Register ASAP

One of my favourite tumours morphology-wise, though not to pronounce. I think that’s a statement that only flies on #PathSky 😬
Adamantinomatous craniopharyngioma.

Delighted to share our recent publication on the state of Pathology Student Interest Groups in U.S. medical schools. Our study highlights current practices and proposes strategies for enhancing student involvement in pathology.

pubmed.ncbi.nlm.nih.gov/40031955/

#Pathology @clilleymd.bsky.social

Koalitionsgespräche von FPÖ und ÖVP geplatzt Über einen Monat haben FPÖ und ÖVP über die Bildung einer neuen Regierung verhandelt. Was sich bereits in den vergangenen Tagen abzeichnete, ist jetzt passiert: Die Koalitionsgespräche sind geplatzt. ...

orf.at/live/5463-Ko...

The case for reducing the use of diagnostic upper and lower gastrointestinal endoscopy Luminal gastroenterology remains a fascinating and diverse specialty, attracting high numbers of applicants to fellowship posts. One potential reason for this popularity is that it is a practical discipline, due to the introduction of fibreoptic endoscopy in the 1960s, wherein physicians see patients and can investigate their symptoms themselves. However, current evidence suggests many diagnostic endoscopies being done are of low yield, which represents an opportunity to enhance the value of care.

New Comment - Black & Ford - The case for reducing the use of diagnostic upper and lower gastrointestinal endoscopy

www.thelancet.com/journals/lan...

#GastroSky #MedSky

The greatest review written on liver biopsy: indications, interpretation, and its future

By Dr Purva Gopal and colleagues in HepCommJournal

Open access journals.lww.com/hepcomm/full...

#liversky #pathsky

We are on our second starter pack for GI / Hepatology
Part 1: go.bsky.app/8Pho2tp
Part 2: go.bsky.app/VGyLKjR

#medsky #GIsky #LiverSky

Super little finding. Patient presented with abdominal pain. Here’s a gastric biopsy… #pathsky #pathology #GIPathology #histology #histopathology

Present...

Nice bridge. Should open KP up a lot for pedestrians and cyclists.

A pedestrian footbridge in front of the Brisbane skyline at night, suspended from a huge suspension tower and lit up in green

The newly opened Kangaroo Point Bridge (Meanjin) is stunning 😍

Annals of Surgical Oncology repost:

December Issue: Identification and Verification of Key Genes in #ColorectalCancer #LiverMetastases Through Analysis of Single-Cell Sequencing Data and TCGA Data

rdcu.be/d1TeM

Two scribes depicted in an ancient Assyrian low relief, using styluses to write on clay tablets.

A cuneiform tablet with writing on it.

For me, the most incredible artefacts from the ancient world are the letters people wrote on clay tablets and sent to one another over thousands of years in Mesopotamia, going back to more than 5,000 years ago.

They contain recognisable humanity, warmth and humour. Here's a thread of my favourites.

Model for C-Kit–dependent trogocytosis regulates niche retention in blood stem cells. A subset of HSCs (marked by high C-Kit expression) can acquire membrane material from adjacent macrophages through trogocytosis (TROGPos HSC) to augment retention in the bone marrow. Stem cells with low C-Kit expression are mobilized to the peripheral blood.ILLUSTRATION: TATYANA A. HARRIS FROM THE EINSTEIN CREATIVE SERVICES TEAM

#MedSky🧪#Hematopoiesis #Clinicalresearch
#Macrophages and #hematopoieticstemcells teach us that sharing is caring @natureportfolio.bsky.social
rdcu.be/dTV5E
www.science.org/doi/10.1126/...

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities Nature Reviews Cancer - Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant...

Thrilled to share our Roadmap to Persister Cancer Cells published in Nature Reviews Cancer. This accomplishment is the result of a collaborative effort by many experts in the field, and I’m proud to represent the RNA community among them
rdcu.be/dSJp4

Very fine people, on both sides. 😕