Lida Zoupi

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.

Apply here 👇
bit.ly/44AFJHx

We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...

Hoping to see old friends and new in Marseille

@dr-vmosienko.bsky.social @philiphasel.bsky.social @drmyelin.bsky.social

We have a booth, please come and say hello

👋👋🏻👋🏼👋🏽👋🏾👋🏿

#gliafriends #networking #neuroscience

Expression of clock genes tracks daily and tidal time in brains of intertidal crustaceans Eurydice pulchra and Parhyale hawaiensis Intertidal organisms, such as the crustaceans Eurydice pulchra and Parhyale hawaiensis, express daily and tidal rhythms of physiology and behavior to …

In the brain of intertidal crustaceans (Eurydice and Parhyale), circadian clock genes are expressed with a daily rhythm (24h) in some cells and a tidal rhythm (12.4h) in other cells. Two different clocks working in the same brain, using the same components.

A common computational and neural anomaly across mouse models of autism - Nature Neuroscience Noel et al. show aberrant updating of expectations in three distinct mouse models of autism spectrum disorder. Brain-wide neurophysiology data suggest this stems from excess units encoding deviations ...

Mice harboring mutations in Fmr1, Cntnap2 or Shank3B show a blunted update of priors during decision-making, suggesting that distinct genetic instantiations of ASD may yield common neurophysiological and behavioral phenotypes

www.nature.com/articles/s41...

#fluorescencefriday takes a look at oligodendrocytes and OPCs in the cleared mouse 🧠 stained for Olig2 and imaged by #lightsheet 🔬 . By @shahrzadbahrampour.bsky.social @kesummers.bsky.social in collaboration with Corey Baron’s lab. @tridentpct.bsky.social @westernubrainscan.bsky.social

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

Such a brilliant idea!

Foldscope! I ll bring it over!

And so it begins….
@aidarodrigo.bsky.social this is all your fault! 🤣
@teamfoldscope.bsky.social

Congratulations to Michelle Monje and Frank Winkler who are awarded The Brain Prize 2025 for pioneering Cancer Neuroscience: Disease-driving interactions between the brain and brain
tumours. Find out more about the 2025 Brain Prize winners at www.thebrainprize.org @brainprize.bsky.social

🧠 Celebrate International Women's Day a little early this year with a talk at the Old Operating Theatre Museum!
🗓️ 3rd March
🕰️ Doors open 5:45pm

🎟️ Book now: https://buff.ly/412qipU
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#InternationalWomensDay #OldOpEvents #MedHist #Neuroscience #OldOpTheatre #CharityEvents #LondonEvents

Thank you Cathy!

The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP-deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in m...

onlinelibrary.wiley.com/doi/full/10....
Hot off the press! We find changes in oligodendrocytes that lack FMRP! An excellent collaboration supported by @sidb-edinburgh.bsky.social .

How many people read the first anonymous view and think oh this must be one of my colleagues? It all sounds horribly familiar...

Our new pipeline is out! We present an ex vivo versatile platform for assessing myelin dynamics of hiPSC oligodendroglia. 🔗 Check it out @STARProtocols: doi.org/10.1016/j.xp...
@erinmgibson.bsky.social @annawilliamslab.bsky.social collaboration lead by Themis Tsarouchas!

The global epidemiology and health burden of the autism spectrum: findings from the Global Burden of Disease Study 2021 The high prevalence and high rank for non-fatal health burden of autism spectrum disorder in people younger than 20 years underscore the importance of early detection and support to autistic young people and their caregivers globally. Work to improve the precision and global representation of our findings is required, starting with better global coverage of epidemiological data so that geographical variations can be better ascertained. The work presented here can guide future research efforts, and importantly, decisions concerning allocation of health services that better address the needs of all autistic individuals.

An exciting day in autism epidemiology - numbers are out from the 2021 GBD study. Who's "disease" framing and associated language aside, this is a big effing deal for understanding the prevalence and impact of autism across the globe, especially in LMICs!

Overall prevalence was 0.79% (0.66-0.93)

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...

New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠

www.nature.com/articles/s41...

Glia-enriched cortical organoids implanted in mice capture astrocyte diversity - Nature Biotechnology The underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of function...

⭐️ Meiyan Wang & Fred H. Gage: Glia-enriched cortical organoids implanted in mice capture astrocyte diversity ⭐️
www.nature.com/articles/s41...

Couple of opportunities up to join the group!
One at postdoc level, but open to senior support path.
One research assistant role.
Please share, or drop a line if you want to learn more!
Or just apply!
Thanks!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

The Royal Society's Newton International Fellowships will open for applications next week on 21 January. These fellowships are for non-UK early career scientists who wish to conduct research in the UK. Find out more on our website: #RSGrants royalsociety.org/grants/newto...

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...

First post at this side.

Latest axon diameter action led by Jenea Bin, in collaboration with Nolan, Mobius, Monk, Werner, and Emery labs.

www.biorxiv.org/content/10.1...

That @biologists.bsky.social has been extremely influential in my career is not an exaggeration. Most of my fav science is in the Company's journals + I've been constantly & generously supported via conference grants, participation in workshops and a recent fellowship to visit another lab. Thank u 🥰

Congrats Sarah!

On January 10th our viral vector service is expanding to include a packaged on request option! You will be able to choose a plasmid, select a preferred serotype, and submit a request — all in one place. Want to learn more? Sign up below for email updates.

info.addgene.org/pac...

A single-cell mass cytometry-based atlas of the developing mouse brain - Nature Neuroscience In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...

A single-cell mass cytometry-based atlas of the developing mouse brain 🧪🧠

www.nature.com/articles/s41...

🧪We’re excited to announce a special issue of the Multiple Sclerosis Journal "Breaking Barriers in MS," which highlights some of the important work presented at #ACTRIMS2024 through editorial, prospective reviews, and a controversies in MS section. Read this special issue here: lnkd.in/dzu6DDJp

The Donlin-Asp lab is looking for PhD students. This is your chance to join a great lab in beautiful Edinburgh. Details here 👇🏻