Safak Er

👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻 #neuron #energy #metabolism #fattyacid #raredisease #HSP #mitochondria #betaoxidation #brain #health #neurodegeneration Read more here: rdcu.be/eIQA0 🧠 🔬

@joensuulab.bsky.social @hilife-helsinki.bsky.social @helsinki.fi @helsinki-biotech.bsky.social

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Saber et al showed that brain neurons donot run “only on glucose”, but require their in-house saturated fatty acids generated by activity dependent enzyme, DDHD2. ⚡️🧈

Looking forward to translation of this finding to aging and neurodegenerative diseases.

Link: www.nature.com/articles/s42...

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It was amazing to be part of this ground-breaking work: “DDHD2 provides a flux of saturated fatty acids for neuronal energy and function”, Nature Metabolism @nature.com

Congratulations to Saber… Joensuu et al and all authors! 🎉

#energy #neuron #mitochondria #fats #fattyacid

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These 99 'lab hacks' will make your scientific work easier Nature asked contributors, editors and working researchers to share their best advice for scientists.

Over the last year, Nature’s Careers team has been tapping into its global community of readers, writers, friends and colleagues to compile a list of laboratory hacks to help make scientists’ working lives easier. Here’s a list of 99 of those hacks. #Academicsky 🧪

The article is packed with deep yet digestible knowledge that all biomedical and neuroscience enthusiasts should read: Check it out for more details!

www.cell.com/neuron/fullt...

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It’s still exciting to witness this revolution started in my student years.

While many of us speculate other way, digital pathology could be an example of how AI and machine learning will create more demand for specialised jobs, while it may reduce mundane and/or error-prone human work.

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(1) to represent more diverse, larger populations, (2) to easily share samples/data with researchers and clinicians, and finally, (3) to play more roles in medical discoveries.

Not to be missed, none could happen w/o contribution of public, including people being treated for 🧠 diseases.

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This great read was in my tabs for a couple of weeks. Until today!

The experts discuss how the new tech, collabs and networks in neuropathology will transform the biomedicine for brain health. And what it needs for the boost!

Shortly, standardisation, accessibility, and education are key…

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Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration Murray et al. introduce “transformative neuropathology” through dynamic, technology-integrated approaches to accelerate tissue-based discoveries and offer actionable strategies to strengthen brain ban...

Why some people have more fit brain cells at 90 when others’ start dying at their 30s? Hard to say! It is hard to study because human 🧠 is the least accessible.

@drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology.

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