Bose Lab Sheffield

Exciting new packages!! Very cool ❄️ to see the new microscope (JEMma) added to the cryoEM facility to keep @AvaArctica company @sheffielduni.bsky.social @mcb-sheffield.bsky.social! (Ok, it does look a little bit like a washing machine!) lookout for more details soon!

The conformational space of RNase P RNA in solution - Nature Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.

Amazing #RNA structural ensembles! Really highlights how important #singlemolecule approaches are for finding mechanism in sustems and models that move! www.nature.com/articles/s41...

Cooperation between Intrinsically Disordered Regions regulates CBP condensate behaviour Creb binding protein (CBP) and EP300 (p300) are transcription coactivators that bind at cis -regulatory elements and regulate gene expression in multicellular organisms. They contain large intrinsical...

Posting this awesome work from the summer led by Katie in our team- currently undergoing some exciting new upgrades :) www.biorxiv.org/content/10.1...

With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here:
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.

Fantastic, well articulated review reconciling how regulatory complexes at the molecular level function in the context of transcriptional condensates.

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705

Bringing the lab account over too!! Check us out at @bose-lab.bsky.social 🧬🥼🧪⚗️🔬🪴