Cell - a Cell Press journal

RNA innate immunity constitutes a barrier for interspecies chimerism Interspecies PSC co-culture induces horizontal RNA transfer that activates innate immunity in “winner” mouse cells, a response that is alleviated by Mavs deletion, thereby enhancing “loser” human PSC survival and chimerism.

Now online! RNA innate immunity constitutes a barrier for interspecies chimerism

Inhibition of oligomeric BAX by an anti-apoptotic dimer A full-length dimeric form of the anti-apoptotic protein BCL-w can block oligomeric BAX-driven mitochondrial permeabilization and apoptosis, revealing a new layer of cell-death control.

Now online! Inhibition of oligomeric BAX by an anti-apoptotic dimer

Fate and state transitions during human blood vessel organoid development (Cell 188, 3329–3348.e1–e18; June 12, 2025)

Now online! Fate and state transitions during human blood vessel organoid development

Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment Clinical evidence from AD patients reveals an association between impaired CCKBR-Gq signaling and disease severity, guiding structure-based design of a Gq-biased agonist that rescues memory and pathology in AD animal models.

Now online! Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment

BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested non-coding regulatory elements, predicts enhancer activity directly from DNA sequence and identifies nucleotides ess...

Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:

Taking programmed cell death from mechanisms to interventions

Together with our partners at Zhejiang University, Liangzhu Laboratory, we're thrilled to announce the Cell Symposium: Taking programmed cell death from mechanisms to interventions, taking place in Hangzhou, China, October 22–24, 2026
http://dlvr.it/TPMsGC
#CSCellDeath26

📝 Online now - the Spotlight "Unlocking the protein code: how our organs age across a lifetime" from Dongxue Wang and Jing Yang.

#Proteostasis #Aging #BiologicalClocks #Proteomics

Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...

Now online! Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

Now online! BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia Reduced levels of the essential metabolite heme are a common feature of acute myeloid leukemia, and consequently, leukemic cells are highly sensitive to inhibition of de novo heme synthesis. Blockade of heme biosynthesis enzymes triggers cuproptosis, a form of copper-dependent cell death that is molecularly distinct from other cell death pathways.

Now online! Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function This perspective discusses how small groups of cells work together in their environment as building blocks called mesoscale modules to form tissues and organs and how understanding these modules will ...

Out at Cell! @cp-cell.bsky.social

We introduce “mesoscale modules”—recurring multicellular functional units that provide a bridge between the behaviours of individual cells and the emergent properties of tissues.

www.cell.com/cell/fulltex...

Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson’s disease

"Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson’s disease"
http://dlvr.it/TPHGB7

Phil Hyu Lee, Dong-Wook Kim & colleagues
@cp-cell.bsky.social
#SfN2025

Nutrient competition predicts gut microbiome restructuring under drug perturbations Systematic profiling of 707 drugs on their impact on stool-derived microbial communities shows that nutrient competition explains and predicts species shifts under drug treatment and that post-drug recovery is driven by ecological interactions like extinction and strain swapping.

Now online! Nutrient competition predicts gut microbiome restructuring under drug perturbations

Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells Long-lived plasma cells that secrete virus-specific IgA at the mucosae are a key determinant in preventing viral infection. Generation of this response is dependent on a unique subset of follicular helper T cells with a type 1 signature—the helper T cells are generated through unconventional priming by B cells and promote the migration of virus-specific IgA+ plasma cells to mucosal effector sites.

Now online! Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells

Ancient RNA expression profiles from the extinct woolly mammoth Ancient RNA profiles from Late Pleistocene woolly mammoths were sequenced from permafrost-preserved mummified tissues, revealing tissue-specific transcriptional functions and gene expression regulatory dynamics. These findings highlight the potential of ancient RNA molecules to provide additional biological information, thus advancing toward integrative paleogenetic research beyond the limits of DNA sequencing alone.

Now online! Ancient RNA expression profiles from the extinct woolly mammoth

Single-cell susceptibility to viral infection is driven by variable cell states Not all cells that can be infected by a virus become infected with that virus. Single-cell clone tracing reveals intrinsic cell states with variable expression patterns that increase susceptibility to viral infection, and this applies for several distinct viruses.

Now online! Single-cell susceptibility to viral infection is driven by variable cell states

Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function This perspective discusses how small groups of cells work together in their environment as building blocks called mesoscale modules to form tissues and organs and how understanding these modules will ...

The issue also features a Perspective on bridging the gap between single-cell phenotypes and the emergent functions of tissues and organs www.cell.com/cell/fulltex...

Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition Minich et al. hypothesized that complete metagenome-assembled genomes, recovered through long-read DNA sequencing, would enable pangenome and microbial genome-wide association analyses to identify mic...

And long-read metagenomic sequencing to characterize the gut microbial communities in undernourished children www.cell.com/cell/fulltex...

Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling, and spatial immune reperto...

And total RNA spatial mapping of clinical fixed samples with Stereo-seq V2 www.cell.com/cell/fulltex...

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis The first-in-human study of anti-BCMA CAR-T therapy for progressive multiple sclerosis shows a favorable safety profile, depletion of plasma cells in the central nervous system, and alleviation of mic...

Also featuring multiple sclerosis patients treated with CAR-T therapy! www.cell.com/cell/fulltex...

New issue is out! 👉 www.cell.com/issue/S0092-...

On the cover: Zhu et al. uncover key genes underlying soybean adaptation and improvement.

Submit your abstract

Are you working on research that challenges the classical function of the immune system? Submit an abstract to @CellSymposia #CSImmuneHomeostasis26 and be considered for a poster or short talk at the meeting in Shanghai, China, May 11–13, 2026 http://dlvr.it/TPFG1j

Pathway-selective 5-HT1AR agonist as a rapid antidepressant strategy Structural and functional analyses of a brain-enriched serotonin receptor, 5-HT1AR, elucidate the molecular basis of Gi/o subtype selectivity, leading to the design of a GoA-preferential agonist that induces rapid antidepressant effects in mice while avoiding autoreceptor activation.

Now online! Pathway-selective 5-HT1AR agonist as a rapid antidepressant strategy

Molecular grammars of predicted intrinsically disordered regions that span the human proteome Grammars inferred using NARDINI+ (GIN) is a resource that uncovers molecular grammars of intrinsically disordered regions (IDRs) across the human proteome, revealing how distinct grammars underlie protein localization, function, and disease associations.

Now online! Molecular grammars of predicted intrinsically disordered regions that span the human proteome

Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction Longitudinal ultrasensitive ctDNA detection improves disease stratification accuracy, demonstrates clinical utility for adjuvant therapy, and reveals insights into characteristic features of relapse in patients with non-small cell lung cancer.

Now online! Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction

Phase separation to buffer growth-mediated dilution in synthetic circuits Phase separation stabilizes synthetic gene circuits and boosts production under dynamic growth conditions. By locally concentrating transcription factors at promoters, it protects gene expression from growth-driven dilution and provides a broadly applicable strategy for gene circuit engineering.

Now online! Phase separation to buffer growth-mediated dilution in synthetic circuits

Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status This study presents a comprehensive evolutionary history of gibbons by resolving their contentious phylogeny, reclassifying an extinct species with ancient DNA, and identifying a structural variant potentially contributing to their limb elongation.

Now online! Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models By sidestepping Cas9 immunogenicity, the StealTHY CRISPR platform enables immune-compatible in vivo genetic screens, directly translatable to humanized cancer models. Using this immune-stealth strategy allows for the discovery of metastatic drivers and reveals the AMH-AMHR2 axis as a clinically actionable pathway for dampening carcinoma metastasis.

Now online! StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration (Cell 188, ▪▪▪–▪▪▪; November 26, 2025)

Now online! Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhancer-promoter communication.

Now online! Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions