Reduction of Antihypertensive Treatment in Nursing Home Residents | NEJM Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. In a multicenter, randomized, controlled trial conducted in France, we assign...

Enough is enough:

RETREAT-FRAIL www.nejm.org/doi/full/10....

OPTIMISE
www.thelancet.com/journals/lan...

DANTON
academic.oup.com/ageing/artic...

No mortality benefit (and potentially harm) from antihypertensive deprescription among frail older adults. Meta-analyze that!

Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social

Some basic facts RFK Jr continues to ignore.

Global health advances have reduced child deaths 75% over the last 50 years.

40% of those gains were from vaccination. And 60% of those gains were from the measles vaccine alone. www.thelancet.com/journals/lan...

Jan Lisiecki @theatredeschampselysees yesterday
#masterful !

#cardiology #cardiovascular #MedSky #EndoSky #CardioSky #RenalSky @thelancetendo.bsky.social @thelancet.bsky.social

Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1–induced platelet reactivity Dose-dependent platelet inhibition by icosapent ethyl contributes to beneficial effects of polyunsaturated omega-3 fatty acids.

Just out in @science.org Translational Medicine - more data supporting the pleiotropic benefits of EPA: Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1–induced platelet reactivity www.science.org/doi/10.1126/... #cardiology #CardioSky #cardiovascular #MedSky #EndoSky

“When spring comes to Paris, the humblest mortal alive must feel that he dwells in paradise.”

Henry Miller, “Tropic of Cancer” 1934.

Sylvia Beach at Shakespeare and Company bookstore, 8 rue Dupuytren, Paris, opened on November 19, 1919.

Abidmian Lalmian Syed.

Akira Kurosawa.

Francisco Sobrino, Untitled, (acrylic on canvas), 1959-1970.

#art#kineticart#artecinetica#opart#drawing
#mixedmedia#geometry#pattern#structure#franciscosobrino.

Stephen Fry's argument against God and His morals.

J. M. W. Turner.

Ettore Sottsas, Untitled (from ‘Geology’ series), (watercolor, gouache, and graphite on heavyweight wove paper), 1998.

Un personnage s'exprime (sans que l'on puisse lire les mots qu'il prononce) tout en marchant sur un tableau de cercles concentriques étiquetés. Le personnage a commencé par le « domaine d'expertise », puis a traversé le « domaine de la compréhension générale », la « province de la connaissance vague », le « domaine de la conscience nébuleuse » et le « domaine de la spéculation douteuse ». La figure est maintenant sur le point de passer de la « région de l'imagination pure » à la « zone de l'ignorance totale ».

Le dimanche matin, il reste pertinent – voire engageant – de poster du Tom Gauld www.tomgauld.com (description et traduction en cliquant sur ALT).

LDLc, CRPus and Lp(a) each independently predict MACE post ACS
@Circulation April 8 #cardiology
#Prevention

Kwame Brathwaite (photograph), The pianist Thelonious Monk performing at the Randalls Island Jazz Festival in 1959.

Emil Cioran - BOTD
💙📚 #LiteratureSky

🚀 Lancement de la plateforme I-REIVAC-Émergence avec
@anrs-mie.bsky.social @inserm.fr : un pas décisif pour la recherche clinique vaccinale

Objectif ➡ évaluer plus rapidement des vaccins contre les maladies infectieuses émergentes et faire de la France un leader européen

🔗 swll.to/zz7uWK

Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism Nature Reviews Cardiology, Published online: 31 March 2025; doi:10.1038/s41569-025-01144-zInhibition of factor XI has emerged as a promising strategy to mitigate bleeding while potentially preserving antithrombotic efficacy. In this Review, the authors comprehensively discuss the rationale, pharmacology, evidence and future directions for factor XI inhibitors across various clinical settings.

New online! Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism #CardioSky

Nicolas de Staël (1914-1955)
Nature morte, 1955.

Atrial Translocation of Porphyromonas gingivalis Exacerbates Atrial Fibrosis and Atrial Fibrillation | Circulation BACKGROUND: Recent studies have indicated an association between periodontitis and atrial fibrillation (AF), although the underlying mechanisms remain unclear. Porphyromonas gingivalis is a causative ...

Atrial Translocation of Porphyromonas gingivalis Exacerbates Atrial Fibrosis and Atrial Fibrillation

www.ahajournals.org/doi/10.1161/...

“It sometimes happens and it will sometimes happen again that I forget who I am and strut before my eyes, like a stranger.”

Samuel Beckett.

Head and shoulders b&w photo portrait of W.G. Sebald, in heavy coat, scarf and spectacles, on a stone river bank.

A rare interview with W.G. Sebald by the brilliant James Wood, in July, 1997 (when Sebald’s only book in English was The Emigrants).

It was from a series called The Writer, The Work, hosted by the PEN American Center, New York.

brickmag.com/an-interview...

Le conseil de l'ordre ne sert à rien et met en danger les patient.e.s.

Exemple [on ne compte plus]

Ma cotisation va encore attendre

Le confrère n'a non seulement pas déshonoré la profession mais il l'a honoré en appelant un chat un chat

Once a doctor has minimized literal death for young people, they have forfeited their right to be taken seriously when they opine on a topic less serious than say, literal death.

sciencebasedmedicine.org/literaldeath...

Inauguration de la place Ady et Gilberte Steg, juifs, résistants, médecins, militante et militant de la mémoire et des institutions juives de France. En donnant leurs noms à cette place, Paris et le 12e arrondissement honorent leur mémoire, leur courage et leurs combats

🎯