Ignacio Saez, PhD

Research Project Manager I (Dr Saez's Lab) - Neurosciences in New York, NY | Mount Sinai Health Systems Mount Sinai is hiring a Research Project Manager I (Dr Saez's Lab) - Neurosciences in New York, NY. Review all of the job details and apply today!

✨ Program Manager Job Alert ✨ Join our Mount Sinai team in NYC to steer a multi-institutional neuroscience initiative aimed at understanding Bipolar Disorder.

If you’re passionate about science, data & impact we’d love to hear from you!

Learn More & Apply 👇
careers.mountsinai.org/jobs/3032351...

What does "Human-centered neural engineering and AI" mean?

It means prioritizing the patient across the entire pipeline: Discovery, Design, and Delivery of neuro-engineering treatments for psychiatric disorders.

Join me to discuss at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social

We are proud to award $18M to four new Discovery Research teams exploring neuromodulation and brain circuits in #Bipolar 🧠📈

🔗bit.ly/48M1TKP

🎙️ Hear from Daniel Pham, PhD, and the teams about their innovative projects 👇

How mood states shift in the brain remains one of psychiatry’s biggest mysteries.

With generous support from @bipolardiscoveries.org, our @sinaibrain.bsky.social team will apply cutting-edge techniques to map these transitions—aiming to build the most precise understanding of bipolar disorder yet.

Must-read #NYBCI25 coverage by @neurotechnology.substack.com in @forbes.com.

My key takeaway on cognitive BCI: Our biggest limiting factor isn't tech—it's fundamental scientific understanding.

We can’t advance the tech until we define the disorder. Basic research must lead the way!

What does it take to move neuroengineering breakthroughs into real-world impact?

Our workshop at @embs.org #NER25 hosted by @onemindaccelerator.bsky.social, will explore how research, startups, and investment can come together to advance mental health care.

neuro.embs.org/2025/satellite-workshops/

"It takes a village!" and I'm incredibly grateful to be a part of this one.

It was inspiring to witness the growing community driving cutting-edge #BCI research from the bench to real life at #NYBCI25

Here’s to building the future of #neurotechnology, together. 🧠⚡

Excited to be speaking at #NYBCI25 this weekend, alongside so many leaders in #Neurotech and #BCI.

It’s rare to have such diverse perspectives in one place, and I’m looking forward to the dialogue that emerges from bringing them together to advance the field.

www.nybci.com/event/2886b6...

I left the 2025 @onemindorg.bsky.social music festival feeling inspired by the advances in mental health research and awareness that, together, are cracking the future of care wide open.

Proud to be part of this community alongside peers like @maryamshanechi.bsky.social & @claudialugo.bsky.social!

❤️Thank you to all of Mount Sinai’s past, present and future #PostdoctoralScholars whose hard work and dedication play a vital role in advancing biomedical research. Here, we celebrate the #SchillerLab’s Dr. @paruljain.bsky.social! #NPAW2025 Learn More about her work👉 www.teenmiso.org/post/intervi...

I'm looking forward to seeing how these findings complement our work in human models & how, together, these approaches can move us toward a unified understanding of the neural mechanisms that shape our decisions.

Everything everywhere all at once: Decision-making signals engage entire brain The findings, gleaned from the most comprehensive map yet of brain activity during decision-making in mice, show that the process is even more distributed than previously thought.

Big congrats to @intlbrainlab.bsky.social on two groundbreaking new papers!

Based on the most comprehensive map of mouse brain activity yet, their findings show how decision-making is both widely distributed and shaped by past experience.

Read more: www.thetransmitter.org/decision-mak...

What I’m reading 👉📚 A powerful & personal piece by
@jacobrobinson.bsky.social (CEO @motifneuro.bsky.social) on how brain-computer interfaces could transform mental health.

Honest, bold & inspiring. I encourage folks to read & subscribe. brainjacob.substack.com

#BCIs #BrainComputerInterface

Data from participants with treatment-resistant depression is revolutionizing our understanding of network disorders 🧠💻

Listen to a great discussion between @crozell.bsky.social and @braininspired.bsky.social on the potential of neuromodulation as a treatment for psychiatric disorders! 🎙️

NOT TO MISS! On Sept 22, 2025, Dr. Peter Rudebeck & The Lipschultz Center for Cognitive Neuroscience invite cognitive neuroscientists to a free symposium showcasing cutting-edge research being conducted across NYC & the surrounding area. Learn More | RSVP friedmanbrain.icahn.mssm.edu/lipschultz-s...

Need reality check on where brain-computer interface technology stands today? 🧠💻

This insightful conversation from @wired.com offers an accessible and grounded introduction to the field, covering what's possible now and some of the challenges that lie ahead.

The development of aperiodic neural activity in the human brain - Nature Human Behaviour This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.

This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.

The development of aperiodic neural activity in the human brain header

How is prefrontal neural activity refined as we age?

Out today in @nathumbehav.nature.com‬! This study, from Elizabeth Johnson, uncovers how subtle changes in neural 'noise' impact our attention, memory, and cognition through development.

Proud to have contributed!

www.nature.com/articles/s41...

As we step into summer, we’re taking a moment to reflect on an amazing past year and offer a warm welcome aboard to our new lab members, @emanuelmcoleman.bsky.social‬ and Henry Asher! We’re thrilled to have you join the Saez Lab team and look forward to an exciting year ahead.

Huge news for Paradromics! 🎉 Their first human implant is a major milestone. Excited to see the Connexus Brain-Computer Interface enter clinical trials, bringing us closer to restoring motor and speech function for people with disabilities. Great coverage from @ashleycapoot.cnbc.com

Looking forward to speaking at #DES2025! I’ll be sharing insights on how brain computer interfaces are helping us advance cognitive neuroscience.

www.des-show.com/agenda-sessi...

What an incredible milestone! 🎉 Proud to celebrate Dr. Arianna Neal Davis, the Saez Lab's first Ph.D. graduate! 🎓

After an exceptional defense, we wish her all the best as she embarks on completing medical school 🥼 So proud to have co-supervised this trailblazer with
@xiaosigu.bsky.social

Thanks to @psypost.bsky.social for the thoughtful coverage of our work exploring the neural basis of human decision-making!

Explore these findings in further detail in our paper: www.jneurosci.org/content/45/1...

Learn more about our work: thesaezlab.com

Had a great conversation hosted by Dr. Josh Bederson about how our lab is revolutionizing our understanding of the brain with intraoperative recordings.

🎞️ Watch to learn how our lab is advancing translational & cognitive neurosciences & neurotechnology: vimeo.com/1079556842/7...

What the Latest Research in Neuroscience Tells Us About Meditation An exploration of the neuroscience of meditation, including recent research as well as future potential for its application.

Unlocking the brain's potential 🔐

Our research investigates how activities like meditation influence human brain activity, revealing pathways for noninvasive neuromodulation.

Thanks to Yoga Journal for highlighting this work.

www.yogajournal.com/meditation/n...

We suggest that low-frequency OFC oscillations in humans reflect risk-taking attitudes & stimulation can alter risk behaviors, informing new therapies for disorders associated with risky behavior.

Congrats Alexandra Skular, Dr. Lu Jin & Dr. Jacqueline Overton on their great work!

(11/11)

As a consequence, when delta-theta coherence is slow, or disrupted through stimulation, patients revert to the safe bet, which does not require strong integration of multiple computations ($10 is $10!). Stimulating OFC causes risk aversion!

(10/11)

How does this work?

We propose that delta-theta coherence serves to integrate reward computations (risk, win probability, etc.) present in high-frequency activity through CFC. Thus, personal preferences (low freqs) and external risk (in high freqs) are integrated.

(9/11)

OFC stimulation was also associated with faster reaction times.

This suggests that stimulation effects on risk preference are distinct from impulsivity, which is often associated with faster reactions.

(8/11)

Strikingly, disruption of delta-theta oscillations via targeted OFC stimulation modulated risk preferences.

Stimulation results in increased risk-averse behavior, which is less dependent on functional integration of multiple reward computations.

(7/11)