Gerald Platzer

Looking forward to visit colleagues in Vienna and Graz 🇦🇹

If you’re in Vienna I’m speaking on:

Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)

&

Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)

NMR-driven structure-based drug discovery by unveiling molecular interactions Communications Chemistry, Published online: 31 May 2025; doi:10.1038/s42004-025-01542-xHigh-resolution 3D structural data are essential for drug discovery, yet X-ray crystallography has limitations in guiding medicinal chemistry. Here, the authors discuss the use of solution-state NMR spectroscopy with selective side-chain labeling and advanced computational workflows to produce accurate protein-ligand ensembles, enhancing structural insights for medicinal chemists and enabling high-throughput applications.

Just out: NMR-driven structure-based drug discovery by unveiling molecular interactions

PhD Position in Structural Biology (f/m/x)

An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details.

jobs.helmholtz-muenchen.de/jobposting/b...

#science #PhD #research

Probing Protein–Ligand Methyl−π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups Fragment-based drug design is heavily dependent on the optimization of initial low-affinity binders. Herein we introduce an approach that uses selective labeling of methyl groups in leucine and isoleu...

Beier et al (2024) Probing Protein–Ligand Methyl−π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups. J Med Chem ASAP #NMR #MedChem #FBDD #FBLD #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1021/acs....

Open Positions 2025 Open Positions 2025

🚨 PhD Opportunity Alert! Repost appreciated!🔁

A fully funded PhD position is available in the Mateos Group at the University of Vienna!

🔹 Up to 4y of funding
🔹 Application deadline: April 21, 2025
👉 More info: doschem.univie.ac.at/application/...

#PhDPosition #Chemistry #Catalysis (1/4)

Synthesis of Selectively 13C/2H/15N-Labelled Arginine to Probe Protein Conformation and Interaction by NMR Spectroscopy The charged arginine side chain is unique in determining many innate properties of proteins, contributing to stability and interaction surfaces, and directing allosteric regulation and enzymatic catal...

📢 New preprint: a new isotope-labeling scheme for NMR studies of Arginines in proteins.

Arginines are often found right where the action happens—like in the active site of enzymes. We use NMR to see their dynamics.

chemrxiv.org/engage/chemr...

Applications to large enzymes are on the way...

#NMR

GitHub - PatWalters/resources_2025: Machine Learning in Drug Discovery Resources 2024 Machine Learning in Drug Discovery Resources 2024. Contribute to PatWalters/resources_2025 development by creating an account on GitHub.

Machine Learning in Drug Discovery Resources page updated for 2025. github.com/PatWalters/r...

We appreciate the shout-out. Thank you! @nmr900.bsky.social 🙏

BioToP stands for "Biomolecular Technology of Proteins" and aims in interdisciplinary training of PhD students.

Super excited that we are able to advertise 12(!) fully funded PhD positions in the field of biomolecular technology of protein interactions.
Check out the exciting projects, spread the word and join BioToP.

#biotechnology #compchem
@bokuvienna.bsky.social @fwf-at.bsky.social

biotop.boku.ac.at

Interested in computational NMR? Join us in beautiful Switzerland in June! Many slots for selected talks and great hiking opportunities.

GRC conference 1-6th of June with GRS ( @chrisdkolloff.bsky.social and Stase) on 30.05.

please share
@nmr900.bsky.social

www.grc.org/computationa...

Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactions Mutational variants of human lysozyme cause a rare but fatal hereditary form of systemic amyloidosis by populating an intermediate state that self-assembles into amyloid fibrils. Despite its significa...

Check out our collaborative study - NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. For CMD ❤️

www.biorxiv.org/content/10.1...

#PostDoc opportunity at University of Vienna in computational #DrugDiscovery & #DrugDesign (Austria) ref: 3336 | duration: 3 years | closing: 19-Jan-2025 #CADD #CompChem #cheminformatics #ML #AI #PostDocJobs #ChemPostDoc #chemsky 🧪
jobs.univie.ac.at/job/Universi...

Dear Michael, thank you for your comment!

In this study, we focused exclusively on the bound state of the streptavidin-biotin complex, aiming to elucidate the molecular interactions and structural determinants that govern the interaction.

I sent you a DM with a more detailed reply. Best, Gerald.

Follow the incredibly talented Aleksandra Ptaszek here: bsky.app/profile/apta...

From Weak Interactions to Strong Affinity: Deciphering the Streptavidin-Biotin Interaction through NMR and Computational Analysis Understanding weak interactions in protein-ligand complexes is essential for advancing drug design. Here, we combine experimental and quantum mechanical approaches to study the streptavidin-biotin com...

📢 New preprint! 📄

Deciphering the molecular forces behind the exceptional binding affinity of the streptavidin-biotin complex via NMR and QM.

🔍 Check it out: www.biorxiv.org/content/10.1...

#StructuralBiology #NMR #ComputationalChemistry #DrugDiscovery

🚨 PhD Positions: Mitochondrial Protein Import/Integrated Structural Biology

Find more info in the attached file or message me directly. I’ll get back to you as soon as I can!

🌟 Know someone perfect for this?
Please share post.

#PhDPositions #StructuralBiology #NMR #CryoEM #Mitochondria #Chaperone