Reinoud Kaldewaij

Bodily Self-Dysfunction in Psychosis: Altered Neural and Spinal Response to Self-produced Sensations Psychosis is often characterized by disturbances in the sense of self, with patients frequently misattributing self-produced sensations to external sources. While somatic hallucinations and mispercept...

🚨Check out our new preprint on Bodily Self-dysfunction in #Psychosis, where we look at the Neural and Spinal Response to #Self-produced Sensations using #Touch and #Interoception

@adamenmalm.bsky.social @rkaldewaij.bsky.social @rebeccaboehme.bsky.social #BRNet

🚨 doi.org/10.1101/2025...
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From algorithmic criminal justice to depressive gut bacteria: 174 researchers receive Veni grant | NWO NWO has awarded Veni funding of up to EUR 320,000 to 174 promising researchers from across the full breadth of science. This will allow the laureates to further develop their own research ideas over t...

Very happy and grateful to receive this grant to study the relationships between social touch, physiological and neural synchrony, and cooperation!

Thanks to everybody who supported me along the way!

www.nwo.nl/en/news/from...

This project was a huge team-effort, by @rebeccaboehme.bsky.social @paulasalamone.bsky.social @adamenmalm.bsky.social and many more. We would also like to thank our participants and the reviewers!

Together, this shows that that disrupting the self-experience through ketamine affects self-other-differentiation in a region involved in touch perception and social cognition, providing further evidence for the intricate relationship of the bodily self with the tactile sense.

Ketamine also led to increased functional connectivity of this temporoparietal region during other- vs. self-touch with several regions, including the insula and primary somatosensory cortex (S1). For S1, the strength of this increase correlated with dissociation symptoms.

The strength of this reduction correlated with ketamine-induced reductions in interoceptive awareness

As shown before, activation in the temporoparietal cortex / secondary somatosensory cortex is attenuated during self-touch compared to other-touch. This difference is preserved during ketamine administration, but clearly reduced.

We investigated this in a double-blind placebo-controlled crossover fMRI study. Participants clearly dissociated more when receiving ketamine compared to placebo.

Ketamine reduces the neural distinction between self- and other-produced affective touch: a randomized double-blind placebo-controlled study - Neuropsychopharmacology Neuropsychopharmacology - Ketamine reduces the neural distinction between self- and other-produced affective touch: a randomized double-blind placebo-controlled study

Excited that our study on ketamine & self- and other-touch has now been published! doi.org/10.1038/s413...
Touch plays a major role in our sense of self and ketamine can disturb our sense of self. So, what happens with the processing of self- and other-generated touch when we receive ketamine? 🧵

Hi all! I am a postdoc in the BoehmeLab at the centre for social and affective neuroscience in Linköping. I'm currently focusing on affective touch & self-other distinction and interested in all things affective / cognitive / social

#AdemicSky #NeuroSkyence #PsychSciSky #HiSciSky #AffectSci #cogsci