Valentina Lo Sardo

Wonderful meeting @aegeanstemcells.bsky.social! An incredible lineup of speakers and spectacular science. Thanks to our own Jeff @epigeneticsmsn.bsky.social for organizing this event. What could be better than having @uwmadscience.bsky.social CRB delegation in sunny Crete? @blanclab.bsky.social

Thanks to the UW-Madison Stem Cell and Regenerative Medicine Center for highlighting our recent work!!🫀🧫🔬

stemcells.wisc.edu/2025/06/04/u...

If you are passionate about stem cells consider coming to Greece for a wonderful lineup of speakers, a lot of networking and amazing science!! Check the website for early registration and travel awards!

Ready for the next three days of great science #VascularDiscovery25

CXCL12 drives natural variation in coronary artery anatomy across diverse populations Coronary dominance is a clinically important developmental phenotype that dictates whether the left or right coronary arteries perfuse the back of the heart. Genome-wide association studies and downst...

CXCL12 drives natural variation in coronary artery anatomy across diverse populations: Cell www.cell.com/cell/fulltex...

This work is led by my first brave PhD student, Elsa Salido
@uwgenetics @UWCVRC with contributions from many in the lab who helped finalize this story. Grateful for the contribution of our fantastic collaborators @clintomics.bsky.social and Jose Verdezoto Mosquera

9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Genome-wide association studies have identified common genetic variants at ≈300 human genomic loci linked to coronary artery disease susceptibility. Among these genomic regions, the most i...

Thrilled to share the🥇paper from the lab @ahajournals.bsky.social. Here we continue to unravel the mysteries of the 9p21.3 CAD locus showing it drives VSMC transition into an osteochondrogenic state, promoting calcification. @clintomics.bsky.social @UWMadison CRB.
www.ahajournals.org/doi/10.1161/...

Congrats to @andreagalmozzi.bsky.social lab for this great study just out in @natmetabolism.bsky.social!! I’m a proud colleague, partner and wife!! ❤️❤️❤️

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

👏🏻👏🏻👏🏻

A foundation model of transcription across human cell types - Nature A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com
For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...

I guess I’ll congratulate you here as well!! Great work Clint!!! Bravo😁🍾

I’ll post it here as well!! Celebrations are never enough 😁! Congratulations Mete!!

An organotypic atlas of human vascular cells - Nature Medicine A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.

🤩❤️ Beautiful atlas of vascular cells in the human body! www.nature.com/articles/s41...