Giordano Lippi

Yeah Marko!

Congrats

🎉

First author @norjin.bsky.social has a different version of the birth of this project. A classic case of convergent evolution.

Rooted in regulation: MicroRNAs as gardeners of the Purkinje cell dendritic arbor Zolboot et al.1 developed tools to manipulate and map microRNA function in cerebellar Purkinje cells with temporal precision, revealing key roles in dendritic development and circuit connectivity. The...

How fitting that the Preview of our Neuron paper was written by the one and only Roy Sillitoe. I saw him giving a talk at the 2018 Neural Development GRC, and his incredible data, storytelling, and enthusiasm convinced me to use Purkinje Cells as a model system.
www.cell.com/neuron/fullt...

Wow! Great stuff Debby congrats!

😂

Congrats buddy! 🎉🎉

Congrats!

Congrats Alex!

Congrats Chen!

Congrats Emilia!

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

Thanks Eric!

Thank you NP

How microRNAs act as a “blueprint” for the developing brain

The Lipp Lab (@lippilab.bsky.social) has uncovered how microRNAs guide the development of Purkinje cells—rare neurons tied to movement and autism.

Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.

😂

Very grateful to Bennie Babayan at @cp-neuron.bsky.social for a fantastic job as editor, and the funding that supported this project. NIH, @autismspeaks.org and @cziscience.bsky.social.

My favorite part is finding cell type-specific post-transcriptional mechanisms that drive morphological diversification among neurons. For example, strong repression in Purkinje cells of genes expressed also in pyramidal neurons is necessary for exuberant arborization! 🤯

MicroRNA mechanisms instructing Purkinje cell specification Zolboot et al. introduce DD-T6B and SAP-seq, methods for investigating microRNA function with enhanced spatiotemporal resolution, and identify Purkinje cell-specific microRNAs and targets instructing ...

Here is a link to the paper:
cell.com/neuron/fullt...

and to the press release from Scripps:
scripps.edu/news-and-event

Delighted to see our paper finally out in @cp-neuron.bsky.social! Together with Ian MacRae, we developed a new toolbox to study microRNAs and used it to find new mechanisms of Purkinje cell development. Please see the tweetorial from researcher extraordinaire @norjin.bsky.social for details.

Yes! See you there. I will send you an email for introduction

My postdoc Fede could help. Let me know if you still need it

Congrats to you and Amanda!

Congratulations Dr. Du! The second student of the Lippi lab to successfully defend her PhD. Very proud PI. And of course, we celebrate in style.

Congrats!

Congrats!

😍

😂

As it ever been OFF is the real question? Thanks for doing such a great job at the CZI webinar