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Joseph Guhlin

@josephguhlin.bsky.social

(he/him) Genomics Researcher. The Kākāpō Genomics Guy. Theoretical Genomicist. Annotation Artist. #Conservation #Bioinformatics #Rust #CompBio πŸ¦€ #genomics #fedi22 #CompBio #popgen #Annotation #Stats #MachineLearning πŸ³οΈβ€πŸŒˆ

200 Followers  |  255 Following  |  45 Posts  |  Joined: 04.09.2023  |  2.0556

Latest posts by josephguhlin.bsky.social on Bluesky

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The full language is even worse, asking to ban gene drives and microbes as well. Would exclude work like this on modified mosquitoes: www.npr.org/2024/01/26/1...

I love the IUCN, but also, they have no political authority, this is just a suggestion. Not a good one though!

06.10.2025 18:35 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Bridging forward-in-time and coalescent simulations using pyslim Ancestral Recombination Graphs (ARGs) provide an expressive and compact way to represent genetic variation data generated by simulations embedded within its genealogical history, and it can dramatical...

www.biorxiv.org/content/10.1...

01.10.2025 19:40 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Photos of past Burpee postdocs with some of our great students at Bucknell.

Photos of past Burpee postdocs with some of our great students at Bucknell.

Excited to begin the search for the next (6th) Burpee Post-Doctoral Fellow in Botany here in my lab at Bucknell! Funded research and teacher-scholar training embedded in the primarily undergraduate institution (#PUI) environment.

#iamabotanist

Details (+ application portal) here:

lnkd.in/eVsbe7K5

01.10.2025 14:40 β€” πŸ‘ 22    πŸ” 25    πŸ’¬ 0    πŸ“Œ 2

Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox refβ€”half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social

www.sciencedirect.com/science/arti...

22.09.2025 17:41 β€” πŸ‘ 48    πŸ” 24    πŸ’¬ 2    πŸ“Œ 4
R and Rust - getting started with extendr
YouTube video by Josiah Parry R and Rust - getting started with extendr

I saw previously the useR extendr package for RUST πŸ¦€ integration and these links are very good m.youtube.com/watch?v=tRm-... and www.ericburden.work/blog/2021/04... and blog.schochastics.net/posts/2025-0... . I went through all and these are enough for having a clear understanding.

20.09.2025 22:44 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Accelerated Bayesian inference of population size history from recombining sequence data - Nature Genetics Population history learning by averaging sampled histories is a new Bayesian method for estimating historical effective population size from recombining sequence data that offers improved speed and ac...

Accelerated Bayesian inference of population size history from recombining sequence data
www.nature.com/articles/s41...

16.09.2025 20:56 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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High Imputation Accuracy Can Be Achieved Using a Small Reference Panel in a Natural Population With Low Genetic Diversity Genotype imputation, the inference of missing genotypes using a reference set of population haplotypes, is a cost-effective tool for improving the quality and quantity of genetic datasets. Imputation...

Genomic imputation can boost dataset quality and benefit research on wild populations. In hihi, we found high #imputation accuracies despite a small reference panel of high-fecundity individuals. Imputation improves downstream #ConservationGenomics analyses. onlinelibrary.wiley.com/doi/10.1111/...

03.09.2025 03:45 β€” πŸ‘ 11    πŸ” 8    πŸ’¬ 1    πŸ“Œ 0
PhD student Hui Zhen presents a slide titled 'A day in the life of a VIP hihi', with images highlighting the conservation management of this precious endangered bird species

PhD student Hui Zhen presents a slide titled 'A day in the life of a VIP hihi', with images highlighting the conservation management of this precious endangered bird species

Fabulous presentation to Forest & Bird Youth Auckland by @huizhentan.bsky.social on conservation management and genetic research for hihi, a taonga (precious) threatened bird species in Aotearoa New Zealand. VIP treatment for a very special bird!

14.09.2025 22:13 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions - Nature Plants This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding and trait introgress...

Breaking genetics newsβ€ΌοΈπŸŒ±πŸŒ½ A natural DNA trick triples recombination in maize. What we first saw in Arabidopsis (@hendersi lab) a decade ago is now confirmed in cropsβ€”opening new doors for plant breeding. Published today in Nature Plants! More details πŸ‘‰ www.nature.com/articles/s41...

02.09.2025 10:19 β€” πŸ‘ 73    πŸ” 25    πŸ’¬ 2    πŸ“Œ 1

Context: this knocks back Marsden funding levels next year a whole two decades to (inflation adjusted) the same level funding as the 2005 Budget.

06.09.2025 23:34 β€” πŸ‘ 47    πŸ” 36    πŸ’¬ 2    πŸ“Œ 1
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Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky url: academic.oup.com/icb/article-...

31.08.2025 20:57 β€” πŸ‘ 490    πŸ” 103    πŸ’¬ 19    πŸ“Œ 7
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Long runs of homozygosity are reliable genomic markers of inbreeding depression A long-standing goal in ecological, evolutionary, and conservation genetics is to identify genomic correlates of fitness and inbreeding depression. Over the past several years, a growing body of theor...

Long runs of homozygosity are reliable genomic markers of inbreeding depression 🧬 www.cell.com/trends/ecolo...

04.08.2025 07:51 β€” πŸ‘ 17    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1

Is it possible journals were 'vibe coding' before the rest of us? Because that's such a design flaw it could only come from an LLM

26.08.2025 00:58 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Cardboard box of apples that says β€œFree Lemons”

Cardboard box of apples that says β€œFree Lemons”

starting to suspect my neighbor is a large language model

15.08.2025 01:44 β€” πŸ‘ 741    πŸ” 94    πŸ’¬ 16    πŸ“Œ 5
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CSIRO PUBLISHING Call for Papers

πŸ“’ Don't just publish, contribute to our special collection- Matriarchs of the Wheatbelt🌾

πŸ•·οΈ Celebrating 50 yrs since Prof. Barbara York Main’s invertebrate monitoring began, we are seeking works on kinship, place & conservation

www.publish.csiro.au/pc/content/C...

πŸ—“οΈ Submission Deadline 30 Nov 2025

18.08.2025 00:30 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 1    πŸ“Œ 1

I love this trend in polyploid research:

β€œWith new data and techniques, we can finally tackle this horribly complicated group!”

β€œAnd guess what? It’s even worse than we imagined!”

But seriously, excellent work!

13.08.2025 20:37 β€” πŸ‘ 29    πŸ” 11    πŸ’¬ 2    πŸ“Œ 0
Terminal listing output of 'ls' with terrible, unreadable color scheme

Terminal listing output of 'ls' with terrible, unreadable color scheme

Who chose this color scheme?

12.08.2025 03:54 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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She was the last: Penguin starvation crisis sparks call for emergency fishing ban The fate of the hoiho - among the world’s rarest penguin species - rests with two ministers.

Pulled lifeless from a commercial fishing net off the Otago coast, the adult female yellow-eyed penguin had drowned in a silent, unseen death.

She was the last known breeding-age female Hoiho from the Sandfly Bay colony.

#NZOverFishing

10.08.2025 20:20 β€” πŸ‘ 203    πŸ” 144    πŸ’¬ 15    πŸ“Œ 21

A PR company working for Colossal Biosciences is sending AI generated pieces to respected science journalists & asking them to publish the articles under their own names. This is so dodgy & just goes to show our critical expert scientific commentary is working. Sci comm failure 101 for Colossal.

10.08.2025 09:08 β€” πŸ‘ 240    πŸ” 97    πŸ’¬ 4    πŸ“Œ 5
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*ALERT! GLOBAL GENETIC DIVERSITY TREND RE-ANALYSIS*

"Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025...

04.08.2025 18:35 β€” πŸ‘ 47    πŸ” 26    πŸ’¬ 1    πŸ“Œ 0

A novel mobile genetic element with virus-like characteristics is widespread in the world's oceans https://www.biorxiv.org/content/10.1101/2025.08.03.668216v1

04.08.2025 03:33 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
A female kākāpō with a small chick on a nest. Credit: Andrew Digby

A female kākāpō with a small chick on a nest. Credit: Andrew Digby

We've lost female #kakapo Kuihi, who was euthanised at Dunedin Wildlife Hospital following weight loss and diagnosis of severe abdominal abnormalities. A reliable (foster) mother, she'll be sorely missed, especially in breeding seasons. There are 241 kākāpō left. #conservation #parrots

25.07.2025 06:20 β€” πŸ‘ 160    πŸ” 22    πŸ’¬ 8    πŸ“Œ 4
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Shock kiwi rediscovery delights conservation world Kiwi pukupuku/little spotted kiwi have been rediscovered in the wild on mainland Aotearoa for the first time in 50 years, shocking and delighting conservationists.

Huge news! Having spent a while studying #kiwi pukupuku, this got me very excited. Finding a remnant mainland population of LSK is probably more significant than finding more #kakapo. Huge respect to those involved and particularly the hunter who found them.
www.doc.govt.nz/news/media-r...

25.07.2025 06:29 β€” πŸ‘ 312    πŸ” 84    πŸ’¬ 5    πŸ“Œ 5

This is for all researchers in Aotearoa (including students, Māori, non Māori) it is an opportunity to contribute to understanding the impact of the VM policy across our sector

15.07.2025 21:08 β€” πŸ‘ 17    πŸ” 23    πŸ’¬ 0    πŸ“Œ 0

One hour!

16.07.2025 00:03 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Genomes mapped for endangered dolphins | Alana Alexander

And @laninsky.bsky.social on waateanews.com/2025/07/14/a... !

14.07.2025 20:21 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Scientists make breakthrough in tracking health of endangered dolphins Scientists working to help track the health of endangered Hector and Maui dolphins have made a breakthrough which they compare to solving a 3 billion piece puzzle. Using that analogy, the puzzle piece...

www.rnz.co.nz/national/pro...

Sebastian Alvarez-Costes spoke to Melissa Chan-Green about endangered Hector and Maui dolphins! Must listen!

#conservation #animals #genomics

14.07.2025 20:20 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1
A kākāpō up a tree during the day, in dappled sunlight. Credit: Maddy Whittaker.

A kākāpō up a tree during the day, in dappled sunlight. Credit: Maddy Whittaker.

Our team have been working hard changing transmitters on all ~90 #kakapo on Whenua Hou, including Vori. Catching kākāpō can be tricky - especially since they often roost up trees. #conservation #parrots Pic: Maddy WhittakerA

14.07.2025 04:44 β€” πŸ‘ 360    πŸ” 64    πŸ’¬ 4    πŸ“Œ 2
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Congratulations to all our #GSA2025 #AotearoaGSA2025 award winners.

Great talks at the GSA award session from @cegrueber.bsky.social, Ashley Jones, Stephanie Waller, and Margaret Byrne.

09.07.2025 23:14 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

@josephguhlin is following 20 prominent accounts