Reactome

⚠️ Upcoming changes:
As of Reactome V94, the following files will no longer be available: “Protégé 2.0 ontology files”, and “Events in the BioPAX level 2 format”. If you require these files for your work, please let our team know via help@reactome.org.

⚠️ Reminder:
As of Reactome V93, our Docker images are no longer available on DockerHub and have been migrated to AWS Elastic Container Registry (ECR). Users should pull images from AWS ECR moving forward.

👏 Thank you to our contributors, authors who have provided expert text and guidance, and peer-reviewers who provide feedback and ensure that everything entering Reactome is accurate. If you are interested in contributing, learn more about how to do so at this link: reactome.org/community

Release News: V93 of #Reactome is live! 🎉

We have new and updated topics and pathways.

💡 Read more about V93 here: reactome.org/about/news/2...

Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome

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Read more about it here: reactome.org/content/reac...

Reactome is now CoreTrustSeal certified, meaning that our pathway data meets global standards for transparency, accessibility & long-term stability. Learn more at reactome.org/about/news/2...

A big win for #FAIRdata, open science, and everyone who relies on Reactome for biological knowledge.
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Check out this recap, where our #Reactome Outreach Coordinator summarizes some of the team discussions we had at #ReactomeSAB 2025!

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No matter where you are in your career— grad student, postdoc, or early-career researcher—you can play a meaningful role in advancing open science and shaping the Reactome knowledgebase.

Reactome is committed to FAIR data principles, meaning your contributions don’t just stay in one place—they’re disseminated globally and reused in a variety of biomedical contexts, from drug discovery to systems biology.

In recognition of their work, contributors receive:
✅ ORCID credit linked to their profile
✅ A citable DOI for each pathway, perfect for CVs and grant applications
✅ Impact—your work becomes part of a resource used by thousands of researchers and integrated into leading bioinformatics platforms.

More than 900 expert scientists have contributed to Reactome by authoring or peer-reviewing pathways, helping ensure the quality and accuracy of this freely available knowledgebase.

YouTube video by Reactome Knowledgebase Contributing to Reactome

Check out our new Youtube video about contributing to Reactome!

Learn more by watching our youtube video, created by Cristoffer Sevilla!
www.youtube.com/watch?v=P5Gi...

Like and subscribe to our Youtube channel for more updates!
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⚠️ In our next version (v93) of Reactome, we will be migrating our Docker image hosting from DockerHub to AWS Elastic Container Registry (ECR). Users will be able to pull our container images from AWS ECR. Please reach out to help@reactome.org if you have any questions.
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A sincere thank you to our external contributors, who provide valuable feedback and review for our pathways. If you are interested in contributing, check out how you can do so, at this link: reactome.org/community
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Reactome Release News: V92 of #Reactome is live! 🎉

We have exciting new and updated topics and pathways in this release. This release, we added 81 new reactions to Reactome, which you can read about at this link: reactome.org/about/news/2...

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GIF showing interacting with the Reactome AI chatbot. The chatbot gives a quick explanation of ECM signaling and offers clickable links to Reactome's knowledgebase.

Discover Pathways with Ease!
Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/

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GIF showing interacting with the Reactome AI chatbot. The chatbot gives a quick explanation of ECM signaling and offers clickable links to Reactome's knowledgebase.

Discover Pathways with Ease!
Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/

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Check out the Reactome Research Spotlight 💡 for February 2025. The paper "BPP: Biochemical Pathway Prediction framework" by Yi et al is summarized here: reactome.org/content/reac...

If you have a publication that leverages Reactome, please submit them to help@reactome.org!

So glad that you found us! Thanks for posting about our work!

#ReactomeResearchSpotlight is updated monthly on our website's homepage! Our staff selects candidate articles to feature. After team discussion, the winner is posted on our home page.

Contact us at help@reactome.org with if you want to be featured as the next Spotlight!

In S2FCD, Oncogene- and Oxidative stress-induced senescence pathways were upregulated and Signaling by TGF-beta receptor complex events were downregulated suggesting distinct subtype-specific therapeutic strategies.

Reactome pathway enrichment analysis revealed subtype-specific dysregulations. In IDICD, the Nuclear receptor transcription factor pathway, Butyrophilin family interactions and Intestinal infectious disease events were upregulated while Cytokine signaling in immune system events were downregulated.

The #ReactomeResearchSpotlight for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids
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🔓Juan Antonio Vizcaino on open data practices in proteomics, highlighting data reuse activities in the context of big data approaches

💻Eliot Ragueneau demonstrating @reactome.org GSA for multi-omics data analysis

#FoG2025

Reactome User Survey Thank you for participating in the Reactome User Survey 2024! Your feedback is valuable in helping us improve our resources and services. We are committed to maintaining the privacy of your data. Al...

It is not too late to participate in our anonymous 5 minute Reactome User Survey, aimed to gather general feedback about our work. docs.google.com/forms/d/e/1F...

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Big shoutout to our contributors! If you are interested in contributing, check out how you can do so, at this link: reactome.org/community

Release News: V91 of #Reactome is live! 🥂 🎉

We have exciting new and updated topics and pathways in this release, which you can read about at this link: reactome.org/about/news/2...

Please consider spending a few moments of your day supporting our resource by providing your feedback to our team! The things we learn from the user survey is essential for our continued success!

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Let's play 20 questions!
If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1F...
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YouTube video by Reactome Knowledgebase Reactomes Downloadable materials

As an #opensource and #public resource, we offer numerous ways for our community to re-use any and every part of the content we create. All you need to do is cite us for our work, so others can also easily find these useful resources.
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