The Jackson Laboratory

Gut microbiome may predict invisible chronic fatigue syndrome and long COVID Previously undetectable biomarkers in gut bacteria, immune responses, and metabolism offer hope for future diagnostic tools.

Hope could be in sight for sufferers of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS and long COVID.

New research shows how the gut microbiome may predict these so-called "invisible" diseases, which are notoriously hard to diagnose.

🧪🧬 #medicine

YouTube video by The Jackson Laboratory JAX in Motion | Revealing The Hidden Genome

🧬 What if your DNA had hidden chapters?

JAX scientists are uncovering structural variations—big genomic changes that help explain disease risk, treatment response, and what makes each of us unique.

#genomics #structuralvariation #science #health #JAXscience #DNA #genome

What rare diseases can teach us about the rest of medicine Why genetic outliers might hold the key to common conditions—and why we should invest more in understanding them

Why study a rare disease that affects only one in a million people? These kinds of genetic outliers might hold the key to common conditions—JAX scientists say we should invest more in understanding them. 🧪🧬

The Complexity of Rare Disease Learn about the complexity of rare disease and the unique difficulty it presents to patients and families by exploring the patient journey—from diagnosis to research to drug development.

🦓 🧬 @jacksonlab.bsky.social's 🆓 resource offers an intro to complexities of #RareDisease.

Whether you’re a researcher, patient or on a care team, you’ll gain insight on how rare conditions are studied within #BiomedicalResearch.

Enroll: education.learning.jax.org/the-complexi...

#MedSky #GeneChat

YouTube video by The Jackson Laboratory JAX in Motion | Revealing The Hidden Genome

🧬 What if your DNA had hidden chapters?

JAX scientists are uncovering structural variations—big genomic changes that help explain disease risk, treatment response, and what makes each of us unique.

#genomics #structuralvariation #science #health #JAXscience #DNA #genome

Gut microbiome may predict invisible chronic fatigue syndrome and long COVID Previously undetectable biomarkers in gut bacteria, immune responses, and metabolism offer hope for future diagnostic tools.

Get the full story on our website: www.jax.org/news-and-ins...

The findings—potentially relevant to #longCOVID due to its similarity with ME/CFS—come from data on 249 individuals analyzed using a new #AI platform that identifies disease biomarkers from stool, blood, and other routine lab tests.

The research was published today in @natureportfolio.nature.com

“Our study achieved 90% accuracy in distinguishing individuals with chronic fatigue syndrome, which is significant because doctors currently lack reliable biomarkers for diagnosis. “Some physicians doubt it as a real disease due to the absence of clear laboratory markers, sometimes attributing it to psychological factors," said Derya Unutmaz, JAX Profession in Immunology

“Our study achieved 90% accuracy in distinguishing individuals with chronic fatigue syndrome, which is significant because doctors currently lack reliable biomarkers for diagnosis,” said study author Derya Unutmaz.

Gut microbiome may predict invisible chronic fatigue syndrome and long COVID Previously undetectable biomarkers in gut bacteria, immune responses, and metabolism offer hope for future diagnostic tools.

Hope could be in sight for sufferers of myalgic encephalomyelitis/chronic fatigue syndrome #MECFS and long COVID.

New research shows how the gut microbiome may predict these so-called "invisible" diseases, which are notoriously hard to diagnose.

🧪🧬 #medicine

The most complete view of the human genome yet sets new standard for use in precision medicine What if scientists unlocked the most hidden, hardest-to-read regions of our DNA?

The new study significantly expands on both efforts, closing 92% of the remaining data gaps and mapping genomic variation across ancestries with a breadth and resolution never achieved.

Learn more: www.jax.org/news-and-ins...

This milestone builds on two foundational studies that reshaped the field of genomics.
2022: The first-ever complete sequence of a single human genome, filling in major gaps left by the original Human Genome Project.
2023: A draft pangenome constructed from 47 individuals

The research reveals how hidden DNA variations influence everything from digestion and immune response to muscle control—and could explain why certain diseases strike some populations harder than others....

The most complete view of the human genome yet sets new standard for use in precision medicine What if scientists unlocked the most hidden, hardest-to-read regions of our DNA?

New research, published today in @natureportfolio.nature.com, decodes the most elusive, difficult-to-sequence regions of the genome from populations around the world, rewriting knowledge of human biology and setting a new benchmark for precision medicine. 🧪🧬🔬

The research, led by JAX's Rare Disease Translational Center (RDTC), Broad Institute, and the nonprofit RARE Hope, was years in the making and follows the first successful gene-editing treatment for a rare liver disease. The findings were published today in Cell.

Genome Editing Corrected Rare Brain Mutations in Mice. Could It Help Fight Neurological Diseases? Expert mouse models and genetic research at JAX drive scientific breakthroughs, ensuring precision and reliability in advancing medical discoveries.

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases. 🧬🧠🔬🧪

So what do the colors mean?

🔵: nuclei of individual cells
🟡: endothelial cells that form blood vessels
🟢: myofibroblasts and perivascular cells
🟠: macrophages
🔴: antigen-presenting cells
Magenta and cyan mark different types of epithelial tumor cells.

This is a rare type of tumor called Sertoli-Leydig tumor, which makes up fewer than 0.5% of all ovarian tumors. Though rare, Sertoli-Leydig tumors can cause significant hormonal imbalances. All tumors are heterogeneous. That means they’re made up of lots of different types of cells all working together. This colorful image shows the tumor tissue at the single-cell level. Each color highlights a different cell type within the tumor’s complex microenvironment. Cutting-edge imaging tools like single-cell sequencing can help scientists visualize and understand how cells work together (or against each other) in a tumor environment. The blue ovals are the nuclei of individual cells. Yellow highlights the endothelial cells that form blood vessels, while magenta and cyan mark different types of epithelial tumor cells. The green strands represent myofibroblasts and perivascular cells—supporting cells often involved in tissue remodeling. Orange spots show macrophages, a type of immune cell that helps clear debris, and red marks antigen-presenting cells, which help alert the immune system to potential threats.

What does a rare ovarian tumor look like—cell by cell? This stunning image reveals a Sertoli-Leydig tumor at the single-cell level, highlighting the diverse cell types that make up its complex microenvironment. 🔬🧬🧪

Learn more: www.jax.org/news-and-ins...

Learn more at JAX.org

YouTube video by The Jackson Laboratory Why Study Rare Disease? JAX's Nadia Rosenthal Talks "Rare to Common"

For JAX scientific director Nadia Rosenthal, the lesson is clear: “Rare diseases often give us a clear window into the fundamental workings of biology,” she said. “And what we see through that window can tell us about much more widespread conditions.”

www.youtube.com/watch?v=c-2m...

What rare diseases can teach us about the rest of medicine Why genetic outliers might hold the key to common conditions—and why we should invest more in understanding them

Why study a rare disease that affects only one in a million people? These kinds of genetic outliers might hold the key to common conditions—JAX scientists say we should invest more in understanding them. 🧪🧬

Cooperative Ph.D. Program The Jackson Laboratory’s Cooperative Ph.D. Program provides training in mammalian genetics and genomic medicine through partnerships with degree-granting academic institutions.

We are proud of these emerging scientific leaders & excited to see how they'll shape #BiomedicalResearch!

Learn about @jacksonlab.bsky.social's Cooperative Ph.D. Training Program, offered via partnerships with Tufts University, UConn Health & UMaine: www.jax.org/education-an...

#PhDChat #PhDSky

JAX awards $10K scholarships to future biomedical leaders The genomics education team at The Jackson Laboratory continues to invest in promising scholars with aspirations in science and medicine.

Congratulations to the three high school seniors from Maine, Connecticut, and greater Sacramento, selected for the JAX College Scholarship program, which awards $10,000 to students from underserved backgrounds pursuing biomedical careers. www.jax.org/news-and-ins...

Driven by a shared mission to advance human health, this new alliance brings together two world-renowned scientific organizations—uniting cutting-edge genomics, stem cell science, and AI-enabled data science. Learn more at jax.org

Pioneering alliance between The Jackson Laboratory and The New York Stem Cell Foundation ushers in new era of predictive biomedical research Uniting cutting-edge genomics, stem cell science, and AI-enabled data science to accelerate the discovery of life-changing therapies

We are thrilled to announce a landmark alliance between The Jackson Laboratory (JAX) and The New York Stem Cell Foundation to transform disease research and accelerate the discovery of life-changing therapies and cures. 🧬🧪

The models offer clear insights into how alternating hemiplegia of childhood progresses—and how it might be stopped. Learn more at jax.org/news

Mouse models for ultra-rare disorder could pave the way for nervous system gene editing therapies The models offer clear insights into how alternating hemiplegia of childhood progresses—and how it might be stopped.

JAX scientists have created new mouse models for alternating hemiplegia of childhood (#AHC) — an ultra-rare, and sometimes deadly, neurological disorder affecting one in a million children. 🧪🧬🧠

These new models allow scientists to mimic specific genetic mutations seen in children with AHC—offering the clearest picture yet of how the disorder progresses, and how it might be stopped. Learn more at jax.org

Spotlight on the 2025 JAX Scholars From the lab bench to long-term goals, postdoctoral scientists Xiurong Cai and Gretchen Clark talk about what fuels their curiosity and how JAX supports their path forward.

2025 JAX Scholar, Xiurong Cai, M.D., studies hematopoietic stem cells with an aim to find key biomarkers to predict disease risk and develop therapies to slow or even stop chronic conditions like blood cancers.
🧪 🧬

Take a closer look: www.jax.org/news-and-ins...

The JAX/ACS Cancer Course 2025 August 11 – 15, 2025 | Virtual Advance your cancer research knowledge and skills The JAX/ACS Cancer Course 2025 provides expert seminars focused on cancer research and experimental modeling. Topics ...

🧪 JAX and 🤝 the American Cancer Society present the JAX/ACS Cancer Course - a virtual course featuring experts on cancer research & experimental modeling.

Join 🖥️ 8/11–15 for an opportunity 🧬 perfect for postbacs, graduate students, postdcos & early career researchers: www.jax.org/education-an...

Precision brain cancer diagnosis What if brain tumors could be more accurately diagnosed? Melissa Kelly and the JAX Advanced Precision Medicine Laboratory are changing the lives of patients through cutting-edge testing.

When doctors diagnose a brain tumor, they often face a high-stakes mystery: Is it slow-growing and treatable or aggressive and terminal? But what if brain tumors could be more accurately diagnosed?

Learn how JAX is changing lives through cutting-edge testing. www.jax.org/news-and-ins...