Kira キラ

The Pushkin job: unmasking the thieves behind an international rare books heist The long read: Between 2022 and 2023, as many as 170 rare and valuable editions of Russian classics were stolen from libraries across Europe. Were the thieves merely low-level opportunists, or were bi...

The Pushkin job: unmasking the thieves behind an international rare books heist

As many as 170 rare and valuable editions of Russian classics were stolen from libraries across Europe. Were the thieves merely low-level opportunists, or were bigger forces at work?

www.theguardian.com/books/2025/o...

Honestly the universe was cooking when it broke my cell phone camera lens. "I'm sorry ma'am, I actually cannot scan the qr code"

thou art damn’d to hell

HIGHLIGHTS •Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons • NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells • NPs improve tumor-free outcomes with memory against multiple aggressive tumor models SUMMARY We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines. Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages. Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells.

Graphical Abstract The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.

Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

BLDGBLOG Architectural Conjecture | Urban Speculation | Landscape Futures

Stream of consciousness architecture blog

bldgblog.com

"I don't think it an act of will, but slowly and almost imperceptibly I managed to extend my sense of neutral, indefinite morning. I concentrated it, intensified that pale-gray awakening and with each morning I found it possible to carry that sensation with me further into the day."

For us it has always been about the days together, day after day, night after night, again and again."
...

"We are not one of those couples that has to have time apart, to miss and rediscover one another to go away and be reunited in a collision of love. Distance, leave-taking and reunions are not what bind us to one another.

YouTube video by Sheena Ringo - Topic Souretsu -Funeral-

A soundscape gothic rock day
youtu.be/vL57NTZAIxc?...

tight leather jacket, baggy jeans and metal framed sunnies like a eurotrash raver going for a pack of smokes

You're in Philly??

cool context about the frog from a quote post, including 🧵reply under it I'm not at all an expert in this domain to be able to verify this, but on a quick check these seem to fit what's said in the post 🐸

especially may be of interest for people confused since different frogs mean other things here

Texting phillies fans congrats like they just gave birth

Screams of red October rattled through the land

Mums will just be silently going through their year then fall hits and they're like 'here the fuck I am!!!'

Can't get over this surreal first date with a person wondering why I would ask about soccer when the sport could lead to injury.

Took me a second to decode the green sperm on the paper

Just stumbled on an old diary entry "maybe I shouldn't have eaten beef stew from the Indonesian corner store with gambling machines"

Just saw the artist afaq share darfuridp.org and wanted to bookmark the organization

Philly things

I shall emerge from this winter with the most obscure and niche deep interests

YouTube video by 柴田範房 花童　～ 民謡三番叟 ～

Working on a new sanbaso dance and found this similar maiko version.

youtu.be/n96DPz90Qec?...

Bookmarking

People assemble and sunken out your corridor facing large black Calder sculpture in Calder Gardens Philadelphia

Purple daisy like wildflowers in Calder Gardens Philadelphia

Mirrored wall of Calder Gardens, Philadelphia

First glimpse of the public Calder Gardens in Philadelphia 🪻

I love you, weird people who live in my phone; let’s win a baseball game

another edgelord run platform

Southern California art guide Read Southern California art guide on Variable West.

My ~spooky season~ picks for Variable West are in! October's all about vouyerism. Peep through the glory holes at Materials & Applications and Noon Projects

Plaza dancing ladies (廣場舞) stopped the music and dancing for a finger-pointing, shrill shouting fight. Sides have formed. 👧🏻🍿

Turkey sandwich with brie, apples and mixed greens. Woo I'm so back on my bs