Mito@GU

Another great mitoretreat with the @nils-goranlarsson.bsky.social group!

The future is visiting again! We are seeking applicants for the 7th season of MITOchats. Deadline for submission is October 17th. Visit www.mitotalks.org for details or submit your application at forms.gle/5D6vWE92yYCi...

🎉 You asked for it… and here it is! The Euromit 2026 website is officially live!

Take advantage of the preferential rate today thanks to EARLY-BIRD Registration

👉 www.euromit2026.eu

#MitochondrialDisease #mtDNA #mitochondria #euromit2026
@ua-recherche.bsky.social

Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year ☀️

📢Check out our wonderful speaker line-up so far!
📅Early-bird & talk deadline: 10 Nov 2025
bit.ly/46xBYVt

#FusionStemCells #FusionAgingResearch

MITOtalks and FocalPlane features... Thursday 3 July 2025, 16:00 BST Image of Yuli Buckley - Fis1 regulates mitochondrial morphology, bioenergetics and removal of mitochondrial DNA damage Yuli Buckley (Case Western Reserve University School of Medicine) Image of Mireia Nager - Mitophagy is induced in human engineered heart tissue after simulated ischemia and reperfusion Mireia Nager (University Hospital of North Norway) Image of Dikaia Tsagkari - NHR-85 modulates mitochondrial and lipid homeostasis to protect against α-synuclein aggregation Dikaia Tsagkari (University of Crete) journals.biologists.com/jcs/issue/138/9 QR code FocalPlane and MITOtalks logo

On Thursday 3 July we are hosting a webinar with @focalplane.bsky.social & @mitotalks.bsky.social to celebrate our recent special issue on the cell biology of #mitochondria, featuring talks from Yuli Buckley, Mireia Nager and Dikaia Tsagkari.

To register: focalplane.biologists.com/2025/06/09/m...

#PostdocOpportunity #Mitochondria #Proteostasis #Ageing #Collaboration #Innovation #STEM

The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions Abstract. The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2–5 b

Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more:
academic.oup.com/nar/article-...

Mitochondria Are More Than Powerhouses — They’re the Motherboard of the Cell - MitoWorld Columbia University mitochondria researcher Martin Picard’s life changed in 2014 when he peered through a microscope in Douglas Wallace’s lab at the Children’s Hospital Philadelphia. He saw something ...

Scientific American has a new (open) article by Columbia’s Martin Picard, comparing mitochondria to microprocessors.

It follows landmark pieces from July 1957 (“Powerhouse of the Cell”) and Aug 1997 (Wallace on mtDNA in aging & disease).

Read our summary:
mitoworld.org/mitochondria...

Special Issue: Cell Biology of Mitochondria - MitoWorld The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...

A must-read for anyone in mitochondria research!

Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!

View our summary mitoworld.org/special-issu...

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182

Only just over a week left to apply for a postdoc position in our lab - if you are passionate about mtDNA maintenance and biochemistry or signaling, here is your chance!

Wellcome Connecting Science Mitochondrial Medicine: Therapeutic Development Conference dates: 10-12 November 2025 Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online Bursary deadline: 11 August Abstract deadline: 8 September Registration deadlines In-person: 13 October Virtual: 3 November Bursary deadline: 11 August Abstract deadline: 8 September In person registration deadline: 13 October Virtual registration deadline: 3 November

Join experts at Mitochondrial Medicine 2025! #MitoMed25

Strengthen your understanding of disease mechanisms, and explore the latest research shaping the future of therapeutic development. #Mitochondria

Leaders will discuss lessons learned from clinical trials.💊

📎 Find out more: bit.ly/4lm1W3L

I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4

Mitochondria – the CEO of the cell Summary: In light of research advances recognizing the roles mitochondria play in directing cellular processes and behaviors, we propose reframing mitochondria as the chief executive organelle of the ...

Mitochondria – the CEO of the cell
journals.biologists.com/jcs/article-...

Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social

Our latest special issue is ‘Cell Biology of Mitochondria’. Over the next few weeks, we’ll be highlighting all the articles from this issue, which was guest edited by Ana Garcia-Saez and Heidi McBride @mitodynamics.bsky.social. Keep an eye on the hashtag #JCSMitoSI.

I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬

📅 registration closes MAY 30th, so don’t wait to snag your spot!

Stay tuned - more updates about the topics and speakers coming soon! 🎙️

First map of human brain mitochondria is ‘groundbreaking’ achievement Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...

(study led by Martin Picard and Michel Thiebaut de Schotten)

🚨 #Postdoc Opportunity! 🚨
The @vkohler-lab.bsky.social @umeauniversitet.bsky.social
is hiring! Join a dynamic team tackling #proteostasis in #ageing, with outstanding mentorship from
@verenakohler.bsky.social - a PI deeply committed to your career development and scientific growth.
Apply now!

🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Swiss Federal Institute of Technology Lausanne (CH): Postdoctoral Position in Human Metabolism, Mitochondria & Behavior (1509) leibniz-psychology.org/produkte/job... #Stellenangebot

Cells are swapping their mitochondria. What does this mean for our health? Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Nature reports on how researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪

New research from our lab on mitochondrial DNA stability
RRM2B is essential for making dNTPs in non-dividing cells and its loss causes mt DNA depletion syndromes.
Surprisingly, we found that RRM2B deficiency leads to a drop in dATP and dGTP.
www.pnas.org/doi/10.1073/...

Thank you!

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

👋Our March issue's out!
Cover: Introducing #blebbisomes

👉🏼Review on #mitochondria #genetics
👉🏼Perspective on #MachineLearning and #SingleCell analyses
🔬 #organelles #autophagy #cancer #autophagy #endocytosis #EmbryoPatterning & more!
www.nature.com/ncb/volumes/...

Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species | Nature Communications Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitochondrial DNA mutation rates show accelerated ageing. A scarcely studied aspect of ageing, because it is invisible in aggregate analyses, is the accumulation of somatic mitochondrial DNA mutations which are unique to single cells (cryptic mutations). We find evidence of cryptic mitochondrial DNA mutations from diverse single-cell datasets, from three species, and discover: cryptic mutations constitute the vast majority of mitochondrial DNA mutations in aged post-mitotic tissues, that they can avoid selection, that their accumulation is consonant with theory we develop, hitting high levels coinciding with species specific mid-late life, and that their presence covaries with a majority of the hallmarks of ageing including protein misfolding and endoplasmic reticulum stress. We identify mechanistic links to endo

Cryptic mtDNA mutations emerge mid-late life, revealing insights across species. In 1M+ cells, they map mitochondrial dysfunction to aging! #AgeingResearch PMID:40050638, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57286-8 #Medsky #Pharmsky #RNAsky 🧪

Excited to share my first postdoc paper - a tool to engineer mtDNA deletions in human cells and study their pathogenic impact ✂️🧬🧫

Welcome! You are invited to join the following webinar: 2025 Westlake Science Symposia. After registration, you will receive a confirmation email with information on how to join the webinar. Mitochondria, the dynamic orchestrators of cellular energy metabolism and signaling, are essential guardians of health. Dysfunction in these organelles underlies a diverse array of pathologies, rangin...

Join me and Patrick Chinnery, Luca Scorrano, Aleksandra Trifunovic, and Min Jiang for the Westlake -
@science.org Online Symposium Wed 28 March 13.00 CET/20.00 China
Mitochondria in health and disease
us02web.zoom.us/webinar/regi...