Centre for Synthetic Biology @TUDarmstadt

On the 16th of October at 14:30 in Darmstadt we are pleased to welcome Bastian Blombach from TU Munich in our SynBio seminar series with a talk entitled: Engineering Corynebacterium glutamicum and Vibrio natriegens for a more sustainable chemical economy.
Join us if you are interested in #Synbio 🧪

Glucose Oxidase Initiates Radical Polymerizations by Direct Electron Transfer to Monomers Glucose oxidase (GOx) is a widely used and studied enzyme, yet it continues to surprise with previously unknown activities. We report GOx to initiate radical polymerizations of acrylamides and methacr...

This is a paper by Eleonora Ornati and Iiulia Ushakova that I am really proud of. Who would have thought that the well-known Glucose Oxidase is up for some surprises, i.e., that it initiates radical polymerizations without the need for initiators or activation by light!
pubs.acs.org/doi/full/10....

🚀 AI meets nanobody engineering!

The group of Harald Kolmar @tuda.bsky.social developed a computational tool to predict aggregation propensities of single-domain immunoglobulins (VHHs), enabling faster discovery & humanization of stable recombinant nanobodies.
www.mdpi.com/2073-4468/14...

Mikrobiologin + LOEWE-Spitzenprofessorin, Katharina Höfer,
@mpi-cbg.de + @unimarburg.bsky.social, lädt Gewinnerinnen von „Jugend forscht“ ins Labor von
@synbio.bsky.social ein, um gemeinsam zu forschen. Mehr zu den beiden Nachwuchsforsch.⤵️+Ihrer Arbeit➡️ www.linkedin.com/posts/proloe... @dfg.de

Talking about enzymatic radical polymerizations in and on cells as well as to create synthetic cells at #EPF2025 @epf2025.bsky.social in beautiful Groningen! What a fantastic gathering of the global polymer community! @metrazymes.bsky.social @tuda.bsky.social @synbio.bsky.social

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells - Nature Communications Silencing of endogenous retroviral elements (ERVs) is mediated by KAP1. Here, the authors describe the molecular mechanism by which KAP1 induces structural reorganization and multimerization of HP1α a...

Our new paper is out:
we explored the role KAP1 and HP1alpha in retroviral elements silencing.
Check it out:
doi.org/10.1038/s414...
cardoso-lab.org/pages/public...
@tuda.bsky.social @synbio.bsky.social

HESSENTAG:𝗟𝗢𝗘𝗪𝗘-𝗙𝗟𝗢𝗪𝗙𝗢𝗥𝗟𝗜𝗙𝗘 𝗵𝗲𝘂𝘁𝗲 𝗺𝗶𝘁 𝘃𝗶𝗲𝗹𝗲𝗻 "𝗠𝗶𝘁𝗺𝗮𝗰𝗵-𝗘𝘅𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝘁𝗲𝗻"➡️𝗦𝘁𝗮𝗻𝗱 𝗱𝗲𝘀 𝗛𝗲𝘀𝘀𝗶𝘀𝗰𝗵𝗲𝗻 𝗠𝗶𝗻𝗶𝘀𝘁𝗲𝗿𝗶𝘂𝗺𝘀 𝗳ü𝗿 𝗪𝗶𝘀𝘀𝗲𝗻𝘀𝗰𝗵𝗮𝗳𝘁 𝘂𝗻𝗱 𝗙𝗼𝗿𝘀𝗰𝗵𝘂𝗻𝗴, 𝗞𝘂𝗻𝘀𝘁 𝘂𝗻𝗱 𝗞𝘂𝗹𝘁𝘂𝗿! Wo? Treffpunkt Hessen (Lageplan Nummer 13) 📌 Stand des Hessischen Ministeriums für Wissenschaft und Forschung (Zelt 1, Stand 111) @tuda.bsky.social

Das LOEWE-ACLF-I Retreat, vom 21.- 22. Mai, in Frankfurt am Main, bot Forscher:innen aller Karrierestufen die Möglichkeit zum wissenschaftlichen Austausch+ zur Vernetzung in entspannter Atmosphäre.👍🏻@aclfi.bsky.social @goetheuni.bsky.social @fraunhofer.bsky.social @pei.de #LOEWE #FORSCHUNG #HESSEN

On the 25th of June at 14:30 in Darmstadt we are pleased to welcome Georg Fritz as part of our SynBio seminar series with a talk entitled: The rise of a „superbug“: Can a marine microbe solve the world’s plastic problem?
Join us if you are interested in #Synbio 🧪

Sustainability prize of the "Freunde der TU Darmstadt"
Really proud of it. Let's save the planet. 🌍

@synbio.bsky.social @tuda.bsky.social

Es war ein toller Tag! Mehr als 4.000 kleine und große Besucher:innen haben gestern den Open Campus der TU Darmstadt gefeiert. Vielen Dank! Einen Bericht und Impressionen findet ihr über den Link 😃 www.tu-darmstadt.de/universitaet...

TUDa Open Campus Tag der Wissen schaf(f)t – Am 25. Mai 2025 öffnet die Technische Universität Darmstadt ihre Türen für die Öffentlichkeit! Der TUDa Open Campus bietet spannende Einblicke in Forschung, Innovation und L...

Heute feiern wir an der TU Darmstadt den Open Campus Day! Von 11 Uhr bis 17 Uhr gibt es auf dem Campus Lichtwiese spannende Einblicke in Forschung, Innovation und Lehre: Talks, Vorträge, Workshops, Führungs, Ausstellungen, Mitmach-Stationen – Euch erwartet ein großes, abwechslungsreiches Programm!

"Sche wars!"Der ProLOEWE-Escape-Room war heute mit seiner🚀 Mars-Mission im Einsatz beim TUDa OpenCampus @tuda.bsky.social. An Bord heute das Team von LOEWE-FLOWFORLIFE @flowforlife.bsky.social & jede Menge Besucher:innen. Danke Euch, Ihr wart toll! #GRUNDLAGENFORSCHUNG #Hessen #Darmstadt

Heute sind wir mit Sacha Vogel|ScienceBirds|+dem ProLOEWE-Planspiel von LOEWE-DiffusibleSignals zum Thema #Antibiotika + #Antibiotikaresistenzen an der Friedrich Magnus Gesamtschule🏫 in Laubach #Hessen! @unimarburg.bsky.social @jlugiessen.bsky.social @mpimicrobiomarburg.bsky.social #LOEWE #Forschung

🐝Heute🍯= #WelttagderBienen! Dass🐝🐝für das Leben auf der🌍🌎🌏unersetzlich sind, ist mittlerweile bekannt. Aber, dass z. B. #Bienengift wirksam🆚Krebs sein kann noch nicht: Auch dazu wird am #FraunhoferIME ▶️LOEWE-ZIB◀️ geforscht➡️www.ime.fraunhofer.de @goetheuni.bsky.social @thm.de @jlugiessen.bsky.social

DLRN beats or matches classical fitting methods—without needing prior model assumptions.

It successfully decoded complex dynamics in:

transient absorption spectra,
DNA strand displacement circuits,
NV-center photoluminescence,
and even multi-scale kinetics split over ns to ms.

Great collaboration spearheaded by Nicolo Alagna with Susanne Gerber and Heinz Koeppl (@tuda.bsky.social). #CoM2Life #SFB1551

Deep Learning Reaction Framework (DLRN) for kinetic modeling of time-resolved data - Communications Chemistry Building kinetic models from time-resolved data can be challenging due to the presence of unknown intermediate states. Here, the authors introduce a deep- learning-based framework that provides a kine...

Our "Deep Learning Reaction Framework (DLRN) for kinetic modeling of time-resolved data" #machinelearning #CRN #systemschemistry A thread to explain:
www.nature.com/articles/s42...

The group of Annette Andrieu-Brunsen @synbio.bsky.social @tuda.bsky.social shows how PMETAC-functionalized mesoporous silica films enable tunable fluid imbibition through osmotic effects—paving the way for advanced sensors and separation technologies.🧪
www.sciencedirect.com/science/arti...

Wir freuen uns im Rahmen des @gdch.de Kolloquiums heute auf Prof. Nico Bruns @synbio.bsky.social @tuda.bsky.social und seinen Vortrag:
"Enzymatic radical polymerizations: Understanding a new-to-nature reactivity to engineer living cells and create synthetic cells"

The Pint of Science Festival starts today #pint25de !!🎉🥳😍 Check out today's programme at the Goldene Krone in Darmstadt. Entry is free! www.pintofscience.de/event/monday...

Check out this year's 𝗣𝗶𝗻𝘁 𝗼𝗳 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗙𝗲𝘀𝘁𝗶𝘃𝗮𝗹 𝗶𝗻 𝗗𝗮𝗿𝗺𝘀𝘁𝗮𝗱𝘁 @pintofscience.de. From the 19th to 21st of May, 15 enthusiastic speakers await you at venues like Goldene Krone, Keller-Klub, Bedouin, and Bruchbude. Entry is free, but a pint of (and for) science never hurts🧪🍻.

Earth's Reflective Secret: Unlocking Albedo from Above Friday Science Bites · Episode

We are excited that the first episode of the 𝐬𝐞𝐜𝐨𝐧𝐝 𝐬𝐞𝐚𝐬𝐨𝐧 of the podcast 𝘍𝘳𝘪𝘥𝘢𝘺 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘉𝘪𝘵𝘦𝘴 is out now! Join Jose Luis to learn about Albedo - what it is and how it can be measured from space. Thanks to Freunde der TU Darmstadt for Sponsoring!🧪 open.spotify.com/episode/1jrf...

Join our Summer School "From idea to Start-Up" in Molecular Biosensing!
📅 22–26 Sept 2025 | 📍Darmstadt & Gernsheim
🎯Topic Molecular Biosensing
💡For MSc, PhD & Postdocs
🔗Network & pitch your own idea!
www.tu-darmstadt.de/synbio/works...
#SynBio #Startup #Biotech #ScienceToBusiness

🚀 Save the date! The German Conference on Synthetic Biology (GCSB) 2026 is happening March 11–13 in Münster 🇩🇪!
🧪 Cutting-edge science
🧬 Top keynote speakers
📢 Abstract deadline: Oct 5 (talks), Jan 31 (posters)
👉 Learn more: gcsb2026.de
#SynBio #GCSB2026 #SyntheticBiology

Elucidating Critical Factors of Internalization and Drug Release of Antibody-Drug Conjugates (ADCs) Using Kinetic Parameters Evaluated by a Novel Tool Named TORCH During the past decade, antibody-drug conjugates (ADCs) have emerged as new drugs in cancer therapy with 15 ADCs already approved such as Kadcyla, Enhertu, and Adcetris. ADCs contain a cytotoxic drug ...

The group of Harald Kolmar @tuda.bsky.social and Birgit Piater @merckkgaa.bsky.social describe the tool TORCH to gain valuable insights on the internalization and drug release of antibody-drug conjugates (ADCs). #CancerResearch 🧪 | Check out the publication: pubs.acs.org/doi/abs/10.1...

Excellent HESSE Special🗞️ProLOEWE-NEWS @goetheuni.bsky.social @tuda.bsky.social @unimarburg.bsky.social @jlugiessen.bsky.social @rheinmainunis.bsky.social @unimainz.bsky.social @heroldlab.bsky.social @flowforlife.bsky.social➡️https://proloewe.de/en/news/news/exzellent-proloewe-news-special-edition/

Join our Summer School "From idea to Start-Up" in Molecular Biosensing!
📅 22–26 Sept 2025 | 📍Darmstadt & Gernsheim
🎯Topic Molecular Biosensing
💡For MSc, PhD & Postdocs
🔗Network & pitch your own idea!
www.tu-darmstadt.de/synbio/works...
#SynBio #Startup #Biotech #ScienceToBusiness

Tuning Ultrasensitivity in Genetic Logic Gates Using Antisense RNA Feedback Inverting genetic logic gates fueled by transcriptional repression is an established building block in genetic circuit design. Often, the gates’ dose–response curves require large changes in dose to t...

The group of Heinz Koeppl @tuda.bsky.social shows the tuning of ultrasensitivity in genetic logic gates using antisense RNA feedback. Check out the paper in ACS Synthetic Biology: pubs.acs.org/doi/10.1021/...