Nat Marshall

Handed in and passed in 2005. Finished in 2012.

So. Much. Mass. Produced. Bullshit.

It would help if I could spell #SleepPeeps correctly...

Hi. I study sleep and sleep disorders using epidemiology and clinical trials

<em>Journal of Sleep Research</em> | ESRS Journal | Wiley Online Library Obstructive sleep apnea (OSA) has been hypothesised to promote cancer via intermittent hypoxia, and assessing what happens when OSA is controlled by continuous positive airway pressure (CPAP) may pro...

Does Sleep Apnea cause cancer and if so what kind/s? One of the ways we can check this is to look at the adverse event tables in the big CPAP randomised trials and see if anything changes. Frustrating answer = still not clear onlinelibrary.wiley.com/doi/10.1111/...

Tax deductible beer if you’re a #sleepeep

From the Damnthatsinteresting community on Reddit: A view of the earth with the Pacific Ocean as the center point. Explore this post and more from the Damnthatsinteresting community

The map all Americans should see www.reddit.com/r/Damnthatsi...

I used to have children who did that

Definately my weirdest scientific idea yet: Can humans sleep one half of their brains at a time when they sleep in water, like dolphins do? Certainly no proof of that yet - but we have a method to maybe catch it. And, Yes, a human can fall asleep floating in a fluid. lnkd.in/gUHSRjug

Cannabinoid products may reduce total sleep time in adults with insomnia: new study Any reduction in sleep time for people with clinical insomnia could be concerning.

Cannabinoid products may reduce total sleep time in adults with insomnia: new study
theconversation.com/cannabinoid-...

Completely scoobied: the confusing world of temperature and pollution effects on sleep apnoea - PubMed Completely scoobied: the confusing world of temperature and pollution effects on sleep apnoea

There’s definately something different between bedroom temp and outdoor temperature that still has me completely scoobied pubmed.ncbi.nlm.nih.gov/26521276/

Ambient temperature and obstructive sleep apnea: effects on sleep, sleep apnea, and morning alertness - PubMed This study is registered in ClinicalTrials.gov number NCT00544752.

Fantastic analysis @bastien-lechat.bsky.social but then I'm thinking back to this pubmed.ncbi.nlm.nih.gov/22467989/

Venn (1866) described the problem with the "sharpshooter fallacy": 🎯 painting the bullseye on the spot where a bullet hits a door.
In psychology, we call this "HARKing" — Hypothesizing After Results Are Known.

We're going to need a bigger boat

Are you assuming your audience is highly educated in the right way?

A graph showing the change from baseline in average sleep latency on the Maintenance of Wakefulness Test (MWT)

In the TAK-861-2001 trial involving 112 participants with narcolepsy type 1, oveporexton significantly improved measures of wakefulness, sleepiness, and cataplexy over a period of 8 weeks. Full trial results: nej.md/3ZdlKNi

#MedSky #NeuroSky

Facepalm

Figure of survival curve showing no difference

There you have it: BEDMED published in @jama.com

jamanetwork.com/journals/jam...

h/t @drjmluther.bsky.social

No difference in bedtime versus morning BP meds - as expected

#NephSky #Hypertension
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SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials High quality protocols facilitate proper planning, conduct, reporting, and external review of randomised trials, yet their completeness varies and key elements are often not considered. To strengthen ...

The new SPIRIT statement 2025 for how to write your clinical trial protocol www.bmj.com/content/389/...

Improving the completeness and transparency of protocols and reports of randomized trials: SPIRIT 2025 and CONSORT 2025 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

New treatments to put insomnia to bed Drugs that eliminate wakefulness, molecules in cannabis and wearable devices that modulate brain activity could help those with the condition.

www.nature.com/articles/d41...

Image shows PDF.

Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent.

Learn more in this Special Communication. https://ja.ma/3Yyu0Hh

Hardly anybody has been trained to read the methods section

Bias written in wooden blocks

Risk of bias assessment of randomised controlled trials has become an essential step in the systematic review process.

A new tool allows users to assess risk of bias of RCTs included in systematic reviews in a user friendly way
www.bmj.com/content/388/...

What role for wakefulness promotors? How well do they really work and what are the side-effects? Julia Chapman and I's latest editorial discussing the latest trial evidence authors.elsevier.com/c/1kkb52p-lG...

Because you don't need a license or any training to publish 'epidemiology'?

People in industrial societies get more sleep than hunter-gatherers Individuals in industrialised societies seem to sleep for longer than people in non-industrialised ones, but their circadian rhythms are more out of sync

Do modern post-industrialised society members sleep more than hunter-gatherers? Somewhat accurately partially quoted in New Scientist. Big sample sizes don't fix the non-representative sampling problem. www.newscientist.com/article/2469...

Not historic enough. Need to upgrade to the Antonine Plague or cholera reactivated from handling John Snow's lab equipment.

Interventions for gut flora to improve health?

And of course one by Senn too...