Laurent Kremer

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In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria - Nature Communications Current treatment options for Mycobacterium marinum infections are extensive and challenging. In this work, authors explore the potential of functionalized mesoporous silica nanoparticles as a carrier for delivery of drugs against M. marinum.

In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular #mycobacteria

(doxycycline-loaded nanoparticles, zebrafish model of Mycobacterium marinum #infection)

@lkremer1.bsky.social

#DrugDevelopment

Call for Papers: Nontuberculous Mycobacterial (NTM) Pathogens─Biology, Infection, and Drug Discovery

Announcing a call for a special issue on Nontuberculous Mycobacterial (NTM) Pathogens, led by our guest editors Sidharth Chopra, Arunava Dasgupta and @lkremer1.bsky.social! Accepting manuscripts on various themes.
Deadline - March 30, 2026.
@pubs.acs.org
Link - pubs.acs.org/doi/10.1021/...

🦠 Intrabacterial lipid inclusion-associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis

🔓https://buff.ly/fI7675n

@canaanlab.bsky.social @lkremer1.bsky.social @pierresantucci.bsky.social

#LipidMetabolism #Mycobacterium

Thrilled to share our most recent paper describing the antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria in macrophages and zebrafish. Outstanding work headed by Yara Tasrini, John Jairo Aguilera Correa, Miguel Gisbert and others.
rdcu.be/eAcN4

Now out in Trends In Microbiology! Iron-sulfur proteins in mycobacteria: Master regulators of physiology and pathogenesis. Kudos to Valentin Berdal and Wassim Daher. Fantastic exchanges and discussions with leaders in the field: Béatrice Py, Sandrine Ollagnier de Choudens
lnkd.in/dKGd2P8S

Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...

It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊

pubs.acs.org/doi/10.1021/...

👋 @lkremer1.bsky.social @cnrs-hautsdefrance.bsky.social @inserm.fr @univlille.bsky.social @ugsf-lille.bsky.social @umontpellier.bsky.social

👉 Lire l'article dans @naturecomms.bsky.social

buff.ly/Z5szsdt

@mirimiam.bsky.social‬ @fedemantica.bsky.social (Gene duplication/ Splicing/ Evolution)
https://doi.org/10.1002/bies.202400202

@lkremer1.bsky.social‬ (Drug discovery/ Non-tuberculous mycobacteria)
https://perspectivesinmedicine.cshlp.org/content/early/2025/03/27/cshperspect.a041832 (29/34)

Happy to let you know that our most recent paper describing the discovery, structure and biological functions of a new glycolipid in M. abscessus is now out ! This has only be possible thanks to a wonderful collaboration with the teams of JL Herrmann and Y Guerardel.
rdcu.be/egVwe

Check out our last collaborative review article on the zebrafish models for drug discovery and therapeutic validation against non-tuberculous mycobacteria. Exciting discussions and interactions with Matt Johansen, Claire Hamela and Yi Ding.
perspectivesinmedicine.cshlp.org/cgi/reprint/...

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...

Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...

Thanks Joel!!

Thrilled to share the last work from the lab! Generating a mycobacterial strain lacking all T7SS and studying the contribution of ESX-3 and ESX-4 in M. abscessus pathogenesis. Great collab with E Tocheva and JL Herrmann.
rdcu.be/d8uHH

Cold Spring Harbor Asia meeting on Mycobacterial Pathogenesis and Host Response, Suzhou, China, March 17-21, 2025. Abstract deadline Jan 10, 2025. www.csh-asia.org?content/2606

Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis - PubMed Mycobacteria produce a large repertoire of surface-exposed lipids with major biological functions. Among these lipids, trehalose polyphleates (TPPs) are instrumental in the infection of <i>Mycobacterium abscessus</i> by the therapeutic phage BPs. However, while the biosynthesis and transport of TPPs …

Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis.

DOI: 10.1128/mbio.02970-24

https://pubmed.ncbi.nlm.nih.gov/39475242/

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social

jbiomedsci.biomedcentral.com/articles/10....

Comprehensive pan-genome analysis of Mycobacterium marinum: insights into genomic diversity, evolution, and pathogenicity - Scientific Reports Scientific Reports - Comprehensive pan-genome analysis of Mycobacterium marinum: insights into genomic diversity, evolution, and pathogenicity

Together with Abdallah and Qingtian we just published this pan-genome analysis for M. marinum. I think it is a nice catalog, but standing out for me was the variation in the cpnT gene and the fact that ESX-2 is present in the majority of the M. marinum strains, just not in the type strain M...

If you're interested in learning about the latest of fundamental mycobacteriology, sign up for #GRCMyco2025! Acceptances will start in September, check out the full program and please RT!