Elif Karagöz

Congrats to Raquel and everyone involved!

Progeroid endothelial cells do not show a robust activation of the unfolded protein response, contrary to what has been reported in other arterial cell types such as vascular smooth muscle cells @maxperutzlabs.ac.at, @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...

Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫

www.nature.com/articles/s41...

A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004 The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Join our vibrant scientific community @viennabiocenter.bsky.social! It’s an extremely supportive environment to start a lab 🚀

www.imp.ac.at/career/open-...

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

New paper alert! Scientists in Julius Brennecke’s lab at IMBA and Clemens Plaschka’s lab at @impvienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: https://imba.science/3Xl2hJ3

Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf

@univie.ac.at
@meduniwien.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

This Halloween, we have a spooky evolutionary story for you.
The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41...
Here’s why I love this work — and why I think you’ll enjoy it too. 👇

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...

Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our latest review is now online! 👇

@martenslab.bsky.social

Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease.
More info in our new paper 👇

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Hijacking a bacterial ABC transporter for genetic code expansion - Nature Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...

it all started years ago with a failed experiment
🧵👇 1/9

RNA biology is a major research focus at the Perutz - and the new @fwf-at.bsky.social grants strengthen it even further 🙌 Elif Karagöz and Pavel Kovarik will investigate how RNA-binding proteins regulate cellular stress and immune responses ➡️ tinyurl.com/2s3f3mu8

@univie.ac.at
@meduniwien.ac.at

A good day to remember John Gurdon’s school report from his biology master at Eton

Happy 10th year birthday to the amazing Bücker lab! Many more fun, successful years to come!

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.

More info: www.imb.de/students-pos...

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Opportunity for skilled hands and sharp minds - at any career stage! 💪 The Köhler Lab is seeking a full-time lab technician to support their research on nuclear envelope biology, chromatin regulation, and cellular stress resilience - apply here ➡️ tinyurl.com/bdfy3w2h

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

Fantastic opportunity. Vienna rocks!