Ute Hellmich

Ready to go!!! 🥳 So looking forward to reconnecting with the membrane peeps at Weill Cornell and making new friends at the Cell Biology of Metals GRC!!! 🤩
It's a brand new world for us, but we will try to Fe-rrociously immerse ourselves in it... 😅

Inhibitor fluorination pattern tunes chemically induced protein dimerization Chemically induced dimerization of proteins is a powerful approach to regulate biomolecular functions through small molecule ligands acting as 'molecular glues'. Here, we demonstrate that simple, thie...

A one day double whammy for our very own Eric in #trypanosome research! 🧪🥳

Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease): tinyurl.com/ywshhxjt 🧲🦟

and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...

Have fun!!!!

soooo jealous!!! Have fun y'all!!! 😭🤣🍹🌵

Very happy to Share that my First paper has been uploaded on bioRxiv 🥳 This was a large team effort together with Jagdeep! We took the next steps into understanding how lipopolysaccharides are transported by the LptB2FGC complex with NMR🧲

So cool! Congratulations!!! 🥳

So screaming at cells if they don't express my favorite protein should work, no? 😂🧪

Big congratulations to Thomas!!! I loved collaborating with his lab during my PhD, and the paper we wrote back then is still one of my all time favorites 🥳 I also appreciated that he was always friendly and had a word of advice for us when we got stuck.

Chaperones in focus: FLI heads new DFG research group on protein folding The German Research Foundation (DFG) is funding seven new research groups (FOR) with a total of €33 million. One of these, DFG-FOR 5872, is dedicated to the role of molecular chaperones in the regulat...

I'm very excited to announce the funding of a new DFG research unit FOR 5872 "Chaperone-mediated regulation of the emergence of disease-causing amyloids inside biomolecular condensates" that I lead together with Simon Alberti. More information can be found here: www.leibniz-fli.de/news-events/...

I do the same thing 😳 So glad I am not alone in this!!!!!

🧪Beyond cool! This has everything you need to sniff out a fabulous weekend read! 🐽😍
Moths in love, membrane receptors, hydrophobic pockets and covalent bonds! 🪰💕🪢

(also, we need more insect emoji...)

This is amazing!!! 😍

We are ready for the last and BEST session of the GRC Mechanism of Membrane Transport!!!! 😉
The secret dynamic lives of channels and transporters...

with Benjamin Orlando, @delemottelab.bsky.social @popstarlab.bsky.social and our amazing chair Dimitrios Stamou!!!

🥳🥳🥳

Bonjour Genève!
So looking forward to seeing all the membrane transport peeps again in a few hours at the GRC Mechanism of Membrane Transport! But first need ro get up that mountain to Les Diablerets 😅 🗻

😪

Both Jena Clusters got funded!!!! 🥳 The emotions are overwhelming!!!
Here's to amazing future science with this incredible team and the amazing people that made it possible!!!

We are ready.... 😬
2 Clusters, 1 community.... everyone on edge 😅

Go Jena!!!!! @microverse.bsky.social @uni-jena.de

Very much enjoyed yesterday's Firmenlauf in Jena. Go Team @uni-jena.de and @microverse.bsky.social with @hellmichgroup.bsky.social Would be great to represent @leibnizfli.bsky.social next year

Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...

yayyyy!!!!🦎😍

amazing... now I want to play 😇

The structure of human sweetness A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods. Single-particle cryo-EM reve...

Sweeeeeet, the corresponding author is called 'Zuker' affiliated with the Zuckerman Institute!!!! 🧪
What else could they have worked on?!? 😂

First structures of human sweet receptor are mindblowingly beautiful!! 🍰🍭😍 And very inspired paper title...

www.cell.com/cell/fulltex...

Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia.

Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease?

Find out more and apply:
my.corehr.com/pls/uoxrecru...

Dear all,

I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!

Thank you! Always fun to figure out that one has had the complelely wrong (or at least a severely limited) impression of certain amino acids 😂

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di-)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids t...

You thought Glu/Asp don't like RNA or DNA? Maybe you even introduced them into your protein to stop such interactions?
😱🧪
Think again! New paper @angewandtechemie.bsky.social with Wöhnert lab shows structural context matters for phosphodiester interactions!
onlinelibrary.wiley.com/doi/10.1002/...

The 15th International ABPP Meeting will be happening in Leiden in 2027. While it is still a long way to go, if you enjoyed this year's edition or were sad that you missed out, make sure to already follow @abpp2027.bsky.social to receive all the information in the future!

oooh that must have been fun!

Not the wurst case science bluesky scenario: This post inspired me to look up a few other papers by the 'brilliant hoot' Fred Menger and led me to this absolute beauty! 🧪

Certainly NO ONE should feel pity for the mundane phospholipid and its inferiority complex as a "sausage casing" 🌭😂 #LipidLove