Ute Hellmich

Congratulations, lieber Bela!!! 🥳🥳🥳

PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS The ankyrin repeat is one of the most abundant protein-protein interaction motifs in eukaryotes yet occurs in only a small number of ion channels. These channels are all members of the transient recep...

🧪 TRPV4 likes to play and its ARD is where other proteins hang out to party!!!! 🥳🥰
We found old & new friends in this systematic study on the V4-ARD interactome and its disruption by disease mutants
led by Sullivan/Sumner labs. So happy we could contribute!

www.jbc.org/article/S002...

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter - Nature Communications The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric pathway critical for function...

Super nice to wake up to the news that our paper on bidirectional communication in an ABC transporter has been selected as a Nature Communications Editors’ Highlight in “Structural biology, biochemistry and biophysics"! 🥳 🥳 🥳
www.nature.com/articles/s41...

@microverse.bsky.social

Thank you, André! 😊

Thank you, Aaron! ABCs rule! 😜

Thank you, Ilya! 😀

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...

🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳

@microverse.bsky.social @lifeprofile.bsky.social

rdcu.be/ePm4C

Our newest lab member has arrived! 😍🥳
Meet James, starring in our new production From Jena with Love. 🎬
#YouOnlyPatchTwice
#TRPChannelsRule

@naniontech.bsky.social

We proudly present:
the 2025 Halloween Lab Pumpkin Carving Edition!!! 😁🥳👻

Quantification of protein homodimer affinity using native mass spectrometry Biological processes rely on finely tuned homo- and heteromeric interactions between (biomacro)molecules. The strength of an interaction, typically given by the dissociation constant (KD), plays a cru...

Confirming both sample integrity and quantifying homodimer interactions? Not so easy - unless you have native MS! ⚖️

Check out our new preprint with Morgner lab using homomeric models and chemically induced dimers of an essential T. brucei enzyme!🧪🥳
@crc1507.bsky.social

arxiv.org/abs/2510.08324

Na, sie hat Dich doch gefunden! War gar nicht so schwierig 🫢😅

Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease | PNAS Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are ...

Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3

🥳🥳🥳🥳That's wonderful! Congratulations!!!!!

The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social

Im glad you and @rohacstibor.bsky.social made it... I was stuck in Brussels for a while, but only a few hours delay in the end...

We're organizing a new CARTA symposium this November 7 on "Ancient DNA: New Revelations"! We have an amazing lineup of speakers who will showcase the biggest discoveries in ancient DNA over the past 5 years - and offer a sneak peek of what's next. Mark your calendars and don't miss it!

Took a TRP to beautiful Leuven and the sensory neurons are all firing....
Came for the Belgian 🍫,
stayed for the🌶🧅 🧊
#TRPChannels #LipidLove

Oh and we are next to each other on the poster! 😊

You had me for a moment though frantically checking the conference dates... but I guess you are right, it's always worth to spend more time in the sweet home of chocolate (don't let the Swiss hear me, though 😂)

YouTube video by Universität Jena THREE QUESTIONS FOR ... Markus Lakemeyer

🔬 In our new “3 Questions for…” episode, junior group leader @mlakemeyer.bsky.social reveals how chemical biology tools help decode microbial interactions & gut microbiota’s role in health & disease – and how this could inspire new therapies. Watch here: www.youtube.com/watch?v=CS54...
@uni-jena.de

It was wonderful to have you visit! Thank you for a great talk and sharing exciting data and tasty Serviettenknödel 😅

I had a great time visiting beautiful Jena this week and learning more about the excellent #ChemBio environment they are building at the @uni-jena.de and the Hans-Knöll-Institut. (1/3)

Imaging lipids! The dream! How cool is that!

B.E.A.U.T.I.F.U.L.
Congratulations, André and everyone involved!!! 😍

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Ready to go!!! 🥳 So looking forward to reconnecting with the membrane peeps at Weill Cornell and making new friends at the Cell Biology of Metals GRC!!! 🤩
It's a brand new world for us, but we will try to Fe-rrociously immerse ourselves in it... 😅

Inhibitor fluorination pattern tunes chemically induced protein dimerization Chemically induced dimerization of proteins is a powerful approach to regulate biomolecular functions through small molecule ligands acting as 'molecular glues'. Here, we demonstrate that simple, thie...

A one day double whammy for our very own Eric in #trypanosome research! 🧪🥳

Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease): tinyurl.com/ywshhxjt 🧲🦟

and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...

Have fun!!!!

soooo jealous!!! Have fun y'all!!! 😭🤣🍹🌵

Very happy to Share that my First paper has been uploaded on bioRxiv 🥳 This was a large team effort together with Jagdeep! We took the next steps into understanding how lipopolysaccharides are transported by the LptB2FGC complex with NMR🧲

So cool! Congratulations!!! 🥳