ernstlaboratory.bsky.social

Miss Rosie, a black and white dog, with staff at the Flint Animal Cancer Center.

In a Flint Animal Cancer Center canine clinical trial, they are testing a novel combination of orally delivered drugs targeting metastasis-promoting white blood cells (WBC), in combination with reprogramming the patient’s cancer fighting WBC to seek out and destroy osteosarcoma.

So jealous. ANA is the best too.

@eirinipapapetrou.bsky.social from the Icahn School of Medicine at Mount Sinai is excited for the rooftop party after the iPSC symposium the day before #ISEH2025 🏯 begins 🌃 Learn more about this event and register! sites.google.com/view/2025ips...

Q: Who are you looking forward to meeting or catching up with at #ISEH2025? A: “Old colleagues and friends whom I have not seen for years, as I missed the last ISEH meeting in Chicago. Of course, I am also looking forward to making new friends this year.“

Take advantage of the chance to see your international friends like Hitoshi Takizawa, PhD from Kumamoto University will be doing at #ISEH2025 🏯. Register for the meeting here: www.iseh.org/2025Registration

Lucky you!

This is really cool. I have had a fantasy of knocking out pol II since the 90s, so it is really nice to see it finally done and thoroughly analyzed.

Thank you so much!

and MCO members...@cucancercenter.bsky.social

Yeah Varuna's thesis work is out!!!!! congratulations Varuna and Sabrina et al

MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells Cyclin D1 accumulation enables a switch in melanoma cells from drug-induced quiescence to proliferation.

New experiments in #ScienceSignaling have uncovered how melanoma and other types of cancer cells can evade therapies by relying on a cell cycle protein—a discovery that could inform more effective combination therapies for these hardy tumors. https://scim.ag/41yQYQf

RESEARCHERS IN ONCOLOGY | QUEBEC CITY Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org/job/chu-de-q...

Welcome New Members graphic. Nicole Kaiser, PharmD, Vicki Catenacci, MD, Mohammad Bilal, MD, John Janetzko, PhD, Wyatt Shields, PhD, Christine Conageski, MD, Ally Nguyen, PhD, Matthew Witkowski, PhD, Peter Fecci, MD, PhD, Stephanie McGrath, DVM, Glen Peterson, DNP, Brenna McGinn, PhD, MSM.

We have new members! Welcome to the CU Cancer Center! 👏

Congratulations @mary-flores.bsky.social‬! what an honor for the lab too ‪@chrmosimann.bsky.social‬

Non-linear transcriptional responses to gradual modulation of transcription factor dosage Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However...

www.biorxiv.org/content/10.1...

link.springer.com/epdf/10.1007...

www.biorxiv.org/content/10.1...

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Future classic

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis The biological mechanisms that sustain the vast blood production required for healthy life remain incompletely understood. To search for novel regulators of hematopoiesis, we performed genome-wide in ...

Cool stuff, lots of @isehsociety.bsky.social royalty
www.biorxiv.org/content/10.1...

Thank you!

Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation The RNA-binding protein hangover is essential for several stress responses in Drosophila melanogaster. Here, we discover a novel function of hangover in the regulation of gene expression. Hangover bin...

Finally, reading that couples my love of both Campari and epigenetics
biorxiv.org/content/earl...

Everyone please read and act! 👇

NEW: BOSTON HAS TURNED OUT!

Thousands join the #HandsOff protest against Trump & Musk on Boston Common.

#FiftyFiftyOne #Resist @youranoncentral.bsky.social
handsoff2025.com

(🎥 Activism Works)

AOC and Bernie in front of the rally crowd in Denver

Zoomed out crowd shot of 34,000 people in downtown Denver with Colorado mountains in the background

Tonight an unbelievable **34,000 people** gathered for our Denver rally to take on billionaires and win our country back.

This was the largest political gathering in Denver since Obama in 2008.

Also bigger than the 2024 DNC.

And the largest ever rally in Bernie’s career (and obviously, mine too).

F*cked up. Another round of calling my representatives to try and dissipate my angst

New CAR-T Cell Therapy Shows Promise for Hard-to-Treat Cancers New CAR-T Cell Therapy Shows Promise for Hard-to-Treat Cancers

Groundbreaking innovation: Researchers at the CU Cancer Center have successfully developed a supercharged iteration of CAR-T cell therapy 🔬 ⬇️

correction, Canada Gooses

If I learned nothing else from Letterkenny, I learned to respect the Canada Goose

Nucleolus and mitochondria I think are my favorite organelles. Such cool little complicated powerhouses.